23XO
Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Rimeporide in an outward-open conformation
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 56 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 58 |
| Details | Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Site: {"description":"Channel pore-lining","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Site: {"description":"Not glycosylated"} |
| Chain | Residue | Details |
