22CR
C5a-desArg bound C5aR2 in complex with beta-arrestin1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000822 | molecular_function | inositol hexakisphosphate binding |
| A | 0001664 | molecular_function | G protein-coupled receptor binding |
| A | 0001934 | biological_process | positive regulation of protein phosphorylation |
| A | 0002029 | biological_process | desensitization of G protein-coupled receptor signaling pathway |
| A | 0002031 | biological_process | G protein-coupled receptor internalization |
| A | 0002092 | biological_process | positive regulation of receptor internalization |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005547 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005905 | cellular_component | clathrin-coated pit |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0006898 | biological_process | receptor-mediated endocytosis |
| A | 0007600 | biological_process | sensory perception |
| A | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| A | 0009968 | biological_process | negative regulation of signal transduction |
| A | 0030132 | cellular_component | clathrin coat of coated pit |
| A | 0030276 | molecular_function | clathrin binding |
| A | 0031143 | cellular_component | pseudopodium |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031623 | biological_process | receptor internalization |
| A | 0032050 | molecular_function | clathrin heavy chain binding |
| A | 0033130 | molecular_function | acetylcholine receptor binding |
| A | 0035612 | molecular_function | AP-2 adaptor complex binding |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| A | 0045880 | biological_process | positive regulation of smoothened signaling pathway |
| A | 0060090 | molecular_function | molecular adaptor activity |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 0072583 | biological_process | clathrin-dependent endocytosis |
| A | 0097499 | biological_process | protein localization to non-motile cilium |
| R | 0002430 | biological_process | complement receptor mediated signaling pathway |
| R | 0004878 | molecular_function | complement component C5a receptor activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| R | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| R | 0009925 | cellular_component | basal plasma membrane |
| R | 0016323 | cellular_component | basolateral plasma membrane |
| R | 0032677 | biological_process | regulation of interleukin-8 production |
| R | 0032715 | biological_process | negative regulation of interleukin-6 production |
| R | 0032720 | biological_process | negative regulation of tumor necrosis factor production |
| R | 0038178 | biological_process | complement component C5a signaling pathway |
| R | 0045177 | cellular_component | apical part of cell |
| R | 0090024 | biological_process | negative regulation of neutrophil chemotaxis |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR193-HIS199 | |
| H | TYR204-HIS210 |
| site_id | PS00295 |
| Number of Residues | 19 |
| Details | ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL |
| Chain | Residue | Details |
| A | PHE61-LEU79 |
| site_id | PS01177 |
| Number of Residues | 35 |
| Details | ANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCydGarvnnde.TCEqraarisl.GprCikafte.CC |
| Chain | Residue | Details |
| C | CYS21-CYS55 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | Domain: {"description":"Anaphylatoxin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00022","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | Region: {"description":"Involved in C5AR1 binding","evidences":[{"source":"PubMed","id":"9553099","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18536718","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KM9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 60 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q695P6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 41 |
| Details | Region: {"description":"Interaction with CHRM2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
