21KT

Wnt3a signalosome extracellular complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001649	biological_process	osteoblast differentiation
A	0001701	biological_process	in utero embryonic development
A	0001756	biological_process	somitogenesis
A	0001819	biological_process	positive regulation of cytokine production
A	0001947	biological_process	heart looping
A	0002092	biological_process	positive regulation of receptor internalization
A	0003713	molecular_function	transcription coactivator activity
A	0005102	molecular_function	signaling receptor binding
A	0005109	molecular_function	frizzled binding
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0007368	biological_process	determination of left/right symmetry
A	0007409	biological_process	axonogenesis
A	0007411	biological_process	axon guidance
A	0007498	biological_process	mesoderm development
A	0007507	biological_process	heart development
A	0008104	biological_process	intracellular protein localization
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009887	biological_process	animal organ morphogenesis
A	0009952	biological_process	anterior/posterior pattern specification
A	0009986	cellular_component	cell surface
A	0010387	biological_process	COP9 signalosome assembly
A	0010467	biological_process	gene expression
A	0010468	biological_process	regulation of gene expression
A	0010628	biological_process	positive regulation of gene expression
A	0010977	biological_process	negative regulation of neuron projection development
A	0016055	biological_process	Wnt signaling pathway
A	0019904	molecular_function	protein domain specific binding
A	0021527	biological_process	spinal cord association neuron differentiation
A	0021766	biological_process	hippocampus development
A	0021846	biological_process	cell proliferation in forebrain
A	0021904	biological_process	dorsal/ventral neural tube patterning
A	0022008	biological_process	neurogenesis
A	0030097	biological_process	hemopoiesis
A	0030168	biological_process	platelet activation
A	0030182	biological_process	neuron differentiation
A	0030198	biological_process	extracellular matrix organization
A	0030509	biological_process	BMP signaling pathway
A	0030879	biological_process	mammary gland development
A	0030890	biological_process	positive regulation of B cell proliferation
A	0030901	biological_process	midbrain development
A	0032212	biological_process	positive regulation of telomere maintenance via telomerase
A	0033278	biological_process	cell proliferation in midbrain
A	0035567	biological_process	non-canonical Wnt signaling pathway
A	0035914	biological_process	skeletal muscle cell differentiation
A	0036342	biological_process	post-anal tail morphogenesis
A	0039706	molecular_function	co-receptor binding
A	0042472	biological_process	inner ear morphogenesis
A	0042802	molecular_function	identical protein binding
A	0045165	biological_process	cell fate commitment
A	0045202	cellular_component	synapse
A	0045595	biological_process	regulation of cell differentiation
A	0045599	biological_process	negative regulation of fat cell differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048018	molecular_function	receptor ligand activity
A	0048103	biological_process	somatic stem cell division
A	0048337	biological_process	positive regulation of mesodermal cell fate specification
A	0048343	biological_process	paraxial mesodermal cell fate commitment
A	0048643	biological_process	positive regulation of skeletal muscle tissue development
A	0048697	biological_process	positive regulation of collateral sprouting in absence of injury
A	0048843	biological_process	negative regulation of axon extension involved in axon guidance
A	0050768	biological_process	negative regulation of neurogenesis
A	0050770	biological_process	regulation of axonogenesis
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050807	biological_process	regulation of synapse organization
A	0060070	biological_process	canonical Wnt signaling pathway
A	0060923	biological_process	cardiac muscle cell fate commitment
A	0061098	biological_process	positive regulation of protein tyrosine kinase activity
A	0061184	biological_process	positive regulation of dermatome development
A	0062009	biological_process	secondary palate development
A	0070507	biological_process	regulation of microtubule cytoskeleton organization
A	0070527	biological_process	platelet aggregation
A	0071542	biological_process	dopaminergic neuron differentiation
A	0090245	biological_process	axis elongation involved in somitogenesis
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0090676	biological_process	calcium ion transmembrane transport via low voltage-gated calcium channel
A	0098978	cellular_component	glutamatergic synapse
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1904339	biological_process	negative regulation of dopaminergic neuron differentiation
A	1905539	biological_process	regulation of postsynapse to nucleus signaling pathway
A	1905606	biological_process	regulation of presynapse assembly
A	1990851	cellular_component	Wnt-Frizzled-LRP5/6 complex
A	1990909	cellular_component	Wnt signalosome
A	2000049	biological_process	positive regulation of cell-cell adhesion mediated by cadherin
A	2000179	biological_process	positive regulation of neural precursor cell proliferation
A	2000347	biological_process	positive regulation of hepatocyte proliferation
A	2000727	biological_process	positive regulation of cardiac muscle cell differentiation
A	2001141	biological_process	regulation of RNA biosynthetic process
C	0003007	biological_process	heart morphogenesis
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005160	molecular_function	transforming growth factor beta receptor binding
C	0005246	molecular_function	calcium channel regulator activity
C	0005515	molecular_function	protein binding
C	0005527	molecular_function	macrolide binding
C	0005528	molecular_function	FK506 binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0006458	biological_process	'de novo' protein folding
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0014802	cellular_component	terminal cisterna
C	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0016529	cellular_component	sarcoplasmic reticulum
C	0030018	cellular_component	Z disc
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0030547	molecular_function	signaling receptor inhibitor activity
C	0032880	biological_process	regulation of protein localization
C	0032926	biological_process	negative regulation of activin receptor signaling pathway
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0034713	molecular_function	type I transforming growth factor beta receptor binding
C	0042026	biological_process	protein refolding
C	0042110	biological_process	T cell activation
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044325	molecular_function	transmembrane transporter binding
C	0050776	biological_process	regulation of immune response
C	0051604	biological_process	protein maturation
C	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
C	0060347	biological_process	heart trabecula formation
C	0070411	molecular_function	I-SMAD binding
C	0070697	molecular_function	activin receptor binding
C	0097435	biological_process	supramolecular fiber organization
C	0098562	cellular_component	cytoplasmic side of membrane
C	1902991	biological_process	regulation of amyloid precursor protein catabolic process
C	1990000	biological_process	amyloid fibril formation
C	1990425	cellular_component	ryanodine receptor complex
D	0003007	biological_process	heart morphogenesis
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005160	molecular_function	transforming growth factor beta receptor binding
D	0005246	molecular_function	calcium channel regulator activity
D	0005515	molecular_function	protein binding
D	0005527	molecular_function	macrolide binding
D	0005528	molecular_function	FK506 binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006457	biological_process	protein folding
D	0006458	biological_process	'de novo' protein folding
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0014802	cellular_component	terminal cisterna
D	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D	0016020	cellular_component	membrane
D	0016529	cellular_component	sarcoplasmic reticulum
D	0030018	cellular_component	Z disc
D	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
D	0030547	molecular_function	signaling receptor inhibitor activity
D	0032880	biological_process	regulation of protein localization
D	0032926	biological_process	negative regulation of activin receptor signaling pathway
D	0033017	cellular_component	sarcoplasmic reticulum membrane
D	0034713	molecular_function	type I transforming growth factor beta receptor binding
D	0042026	biological_process	protein refolding
D	0042110	biological_process	T cell activation
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0044325	molecular_function	transmembrane transporter binding
D	0050776	biological_process	regulation of immune response
D	0051604	biological_process	protein maturation
D	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
D	0060347	biological_process	heart trabecula formation
D	0070411	molecular_function	I-SMAD binding
D	0070697	molecular_function	activin receptor binding
D	0097435	biological_process	supramolecular fiber organization
D	0098562	cellular_component	cytoplasmic side of membrane
D	1902991	biological_process	regulation of amyloid precursor protein catabolic process
D	1990000	biological_process	amyloid fibril formation
D	1990425	cellular_component	ryanodine receptor complex
E	0001649	biological_process	osteoblast differentiation
E	0001701	biological_process	in utero embryonic development
E	0001756	biological_process	somitogenesis
E	0001819	biological_process	positive regulation of cytokine production
E	0001947	biological_process	heart looping
E	0002092	biological_process	positive regulation of receptor internalization
E	0003713	molecular_function	transcription coactivator activity
E	0005102	molecular_function	signaling receptor binding
E	0005109	molecular_function	frizzled binding
E	0005125	molecular_function	cytokine activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0007165	biological_process	signal transduction
E	0007267	biological_process	cell-cell signaling
E	0007368	biological_process	determination of left/right symmetry
E	0007409	biological_process	axonogenesis
E	0007411	biological_process	axon guidance
E	0007498	biological_process	mesoderm development
E	0007507	biological_process	heart development
E	0008104	biological_process	intracellular protein localization
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009887	biological_process	animal organ morphogenesis
E	0009952	biological_process	anterior/posterior pattern specification
E	0009986	cellular_component	cell surface
E	0010387	biological_process	COP9 signalosome assembly
E	0010467	biological_process	gene expression
E	0010468	biological_process	regulation of gene expression
E	0010628	biological_process	positive regulation of gene expression
E	0010977	biological_process	negative regulation of neuron projection development
E	0016055	biological_process	Wnt signaling pathway
E	0019904	molecular_function	protein domain specific binding
E	0021527	biological_process	spinal cord association neuron differentiation
E	0021766	biological_process	hippocampus development
E	0021846	biological_process	cell proliferation in forebrain
E	0021904	biological_process	dorsal/ventral neural tube patterning
E	0022008	biological_process	neurogenesis
E	0030097	biological_process	hemopoiesis
E	0030168	biological_process	platelet activation
E	0030182	biological_process	neuron differentiation
E	0030198	biological_process	extracellular matrix organization
E	0030509	biological_process	BMP signaling pathway
E	0030879	biological_process	mammary gland development
E	0030890	biological_process	positive regulation of B cell proliferation
E	0030901	biological_process	midbrain development
E	0032212	biological_process	positive regulation of telomere maintenance via telomerase
E	0033278	biological_process	cell proliferation in midbrain
E	0035567	biological_process	non-canonical Wnt signaling pathway
E	0035914	biological_process	skeletal muscle cell differentiation
E	0036342	biological_process	post-anal tail morphogenesis
E	0039706	molecular_function	co-receptor binding
E	0042472	biological_process	inner ear morphogenesis
E	0042802	molecular_function	identical protein binding
E	0045165	biological_process	cell fate commitment
E	0045202	cellular_component	synapse
E	0045595	biological_process	regulation of cell differentiation
E	0045599	biological_process	negative regulation of fat cell differentiation
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0048018	molecular_function	receptor ligand activity
E	0048103	biological_process	somatic stem cell division
E	0048337	biological_process	positive regulation of mesodermal cell fate specification
E	0048343	biological_process	paraxial mesodermal cell fate commitment
E	0048643	biological_process	positive regulation of skeletal muscle tissue development
E	0048697	biological_process	positive regulation of collateral sprouting in absence of injury
E	0048843	biological_process	negative regulation of axon extension involved in axon guidance
E	0050768	biological_process	negative regulation of neurogenesis
E	0050770	biological_process	regulation of axonogenesis
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0050807	biological_process	regulation of synapse organization
E	0060070	biological_process	canonical Wnt signaling pathway
E	0060923	biological_process	cardiac muscle cell fate commitment
E	0061098	biological_process	positive regulation of protein tyrosine kinase activity
E	0061184	biological_process	positive regulation of dermatome development
E	0062009	biological_process	secondary palate development
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0070527	biological_process	platelet aggregation
E	0071542	biological_process	dopaminergic neuron differentiation
E	0090245	biological_process	axis elongation involved in somitogenesis
E	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
E	0090676	biological_process	calcium ion transmembrane transport via low voltage-gated calcium channel
E	0098978	cellular_component	glutamatergic synapse
E	1903078	biological_process	positive regulation of protein localization to plasma membrane
E	1904339	biological_process	negative regulation of dopaminergic neuron differentiation
E	1905539	biological_process	regulation of postsynapse to nucleus signaling pathway
E	1905606	biological_process	regulation of presynapse assembly
E	1990851	cellular_component	Wnt-Frizzled-LRP5/6 complex
E	1990909	cellular_component	Wnt signalosome
E	2000049	biological_process	positive regulation of cell-cell adhesion mediated by cadherin
E	2000179	biological_process	positive regulation of neural precursor cell proliferation
E	2000347	biological_process	positive regulation of hepatocyte proliferation
E	2000727	biological_process	positive regulation of cardiac muscle cell differentiation
E	2001141	biological_process	regulation of RNA biosynthetic process
G	0003007	biological_process	heart morphogenesis
G	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
G	0005160	molecular_function	transforming growth factor beta receptor binding
G	0005246	molecular_function	calcium channel regulator activity
G	0005515	molecular_function	protein binding
G	0005527	molecular_function	macrolide binding
G	0005528	molecular_function	FK506 binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006457	biological_process	protein folding
G	0006458	biological_process	'de novo' protein folding
G	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G	0014802	cellular_component	terminal cisterna
G	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
G	0016020	cellular_component	membrane
G	0016529	cellular_component	sarcoplasmic reticulum
G	0030018	cellular_component	Z disc
G	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
G	0030547	molecular_function	signaling receptor inhibitor activity
G	0032880	biological_process	regulation of protein localization
G	0032926	biological_process	negative regulation of activin receptor signaling pathway
G	0033017	cellular_component	sarcoplasmic reticulum membrane
G	0034713	molecular_function	type I transforming growth factor beta receptor binding
G	0042026	biological_process	protein refolding
G	0042110	biological_process	T cell activation
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0044325	molecular_function	transmembrane transporter binding
G	0050776	biological_process	regulation of immune response
G	0051604	biological_process	protein maturation
G	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
G	0060347	biological_process	heart trabecula formation
G	0070411	molecular_function	I-SMAD binding
G	0070697	molecular_function	activin receptor binding
G	0097435	biological_process	supramolecular fiber organization
G	0098562	cellular_component	cytoplasmic side of membrane
G	1902991	biological_process	regulation of amyloid precursor protein catabolic process
G	1990000	biological_process	amyloid fibril formation
G	1990425	cellular_component	ryanodine receptor complex
H	0003007	biological_process	heart morphogenesis
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005160	molecular_function	transforming growth factor beta receptor binding
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005527	molecular_function	macrolide binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006457	biological_process	protein folding
H	0006458	biological_process	'de novo' protein folding
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0014802	cellular_component	terminal cisterna
H	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0030018	cellular_component	Z disc
H	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
H	0030547	molecular_function	signaling receptor inhibitor activity
H	0032880	biological_process	regulation of protein localization
H	0032926	biological_process	negative regulation of activin receptor signaling pathway
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0034713	molecular_function	type I transforming growth factor beta receptor binding
H	0042026	biological_process	protein refolding
H	0042110	biological_process	T cell activation
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0044325	molecular_function	transmembrane transporter binding
H	0050776	biological_process	regulation of immune response
H	0051604	biological_process	protein maturation
H	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
H	0060347	biological_process	heart trabecula formation
H	0070411	molecular_function	I-SMAD binding
H	0070697	molecular_function	activin receptor binding
H	0097435	biological_process	supramolecular fiber organization
H	0098562	cellular_component	cytoplasmic side of membrane
H	1902991	biological_process	regulation of amyloid precursor protein catabolic process
H	1990000	biological_process	amyloid fibril formation
H	1990425	cellular_component	ryanodine receptor complex

Functional Information from PROSITE/UniProt

site_id	PS00246
Number of Residues	10
Details	WNT1 Wnt-1 family signature. CKCHGLSGsC

Chain	Residue	Details
A	CYS203-CYS212

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Site: {"description":"Cleavage; by TIKI1 and TIKI2","evidences":[{"source":"PubMed","id":"22726442","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Lipidation: {"description":"O-palmitoleoyl serine; by PORCN","evidences":[{"source":"PubMed","id":"17141155","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24798332","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25771893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Region: {"description":"Wnt-binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 13"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	78
Details	Repeat: {"description":"LDL-receptor class B 14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 15"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	82
Details	Domain: {"description":"EGF-like 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	96
Details	Repeat: {"description":"LDL-receptor class B 16"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 17"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 18"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 19"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 20"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	82
Details	Domain: {"description":"EGF-like 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	518
Details	Region: {"description":"Beta-propeller 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	538
Details	Region: {"description":"Beta-propeller 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22000856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---