Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004517 | molecular_function | nitric-oxide synthase activity |
A | 0006809 | biological_process | nitric oxide biosynthetic process |
A | 0020037 | molecular_function | heme binding |
B | 0004517 | molecular_function | nitric-oxide synthase activity |
B | 0006809 | biological_process | nitric oxide biosynthetic process |
B | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACT A 860 |
Chain | Residue |
A | GLY417 |
A | TRP587 |
A | VAL649 |
A | SER657 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT B 861 |
Chain | Residue |
B | GLY417 |
B | TRP587 |
B | HOH1125 |
B | HOH1192 |
B | HOH1197 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 900 |
Chain | Residue |
A | CYS326 |
A | CYS331 |
B | CYS326 |
B | CYS331 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE MTL A 870 |
Chain | Residue |
A | SER477 |
A | ARG481 |
A | ALA497 |
A | ASN498 |
A | GLN500 |
A | PHE501 |
A | ASN569 |
A | ASP709 |
A | TRP711 |
A | DP1790 |
A | HOH965 |
A | HOH1046 |
A | HOH1138 |
A | HOH1143 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE MTL B 871 |
Chain | Residue |
B | SER477 |
B | ARG481 |
B | ALA497 |
B | ASN498 |
B | GLN500 |
B | PHE501 |
B | ASN569 |
B | ASP709 |
B | TRP711 |
B | DP1791 |
B | HOH967 |
B | HOH996 |
B | HOH1088 |
site_id | AC6 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE HEM A 750 |
Chain | Residue |
A | TRP409 |
A | ARG414 |
A | CYS415 |
A | SER457 |
A | PHE584 |
A | SER585 |
A | TRP587 |
A | GLU592 |
A | TRP678 |
A | TYR706 |
A | H4B760 |
A | DP1790 |
A | HOH906 |
A | HOH908 |
A | HOH964 |
A | HOH995 |
site_id | AC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE H4B A 760 |
Chain | Residue |
A | SER334 |
A | VAL336 |
A | ARG596 |
A | VAL677 |
A | TRP678 |
A | HEM750 |
A | GOL880 |
A | HOH901 |
A | HOH906 |
A | HOH911 |
B | TRP676 |
B | PHE691 |
B | HIS692 |
site_id | AC8 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE DP1 A 790 |
Chain | Residue |
A | SER477 |
A | GLN478 |
A | PRO565 |
A | VAL567 |
A | ASN569 |
A | SER585 |
A | GLY586 |
A | TRP587 |
A | GLU592 |
A | TYR706 |
A | HEM750 |
A | MTL870 |
A | GOL880 |
A | HOH947 |
A | HOH949 |
A | HOH995 |
A | HOH1112 |
site_id | AC9 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE HEM B 750 |
Chain | Residue |
B | HOH886 |
B | HOH895 |
B | HOH939 |
B | HOH1003 |
B | HOH1129 |
B | TRP409 |
B | ALA412 |
B | ARG414 |
B | CYS415 |
B | SER457 |
B | PHE584 |
B | SER585 |
B | TRP587 |
B | GLU592 |
B | TRP678 |
B | TYR706 |
B | H4B761 |
B | DP1791 |
site_id | BC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE H4B B 761 |
Chain | Residue |
A | TRP676 |
A | PHE691 |
A | HIS692 |
A | HOH992 |
B | SER334 |
B | VAL336 |
B | ARG596 |
B | VAL677 |
B | TRP678 |
B | HEM750 |
B | GOL881 |
B | HOH882 |
B | HOH895 |
B | HOH909 |
site_id | BC2 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE DP1 B 791 |
Chain | Residue |
B | SER477 |
B | GLN478 |
B | ARG481 |
B | PRO565 |
B | VAL567 |
B | ASN569 |
B | SER585 |
B | GLY586 |
B | TRP587 |
B | GLU592 |
B | TRP678 |
B | TYR706 |
B | HEM750 |
B | MTL871 |
B | GOL881 |
B | HOH919 |
B | HOH929 |
B | HOH958 |
B | HOH1003 |
B | HOH1129 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 880 |
Chain | Residue |
A | VAL336 |
A | ARG596 |
A | TRP678 |
A | H4B760 |
A | DP1790 |
A | HOH956 |
A | HOH976 |
A | HOH1157 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL B 881 |
Chain | Residue |
A | HOH992 |
B | VAL336 |
B | ARG596 |
B | TRP678 |
B | H4B761 |
B | DP1791 |
B | HOH1018 |
B | HOH1038 |
B | HOH1113 |
Functional Information from PROSITE/UniProt
site_id | PS60001 |
Number of Residues | 8 |
Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
Chain | Residue | Details |
A | ARG414-TRP421 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | SER334 | |
B | SER334 | |
B | GLN478 | |
B | TRP587 | |
B | TYR588 | |
B | GLU592 | |
B | VAL677 | |
B | TRP678 | |
B | PHE691 | |
B | TYR706 | |
A | GLN478 | |
A | TRP587 | |
A | TYR588 | |
A | GLU592 | |
A | VAL677 | |
A | TRP678 | |
A | PHE691 | |
A | TYR706 | |
Chain | Residue | Details |
A | CYS415 | |
B | CYS415 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 3nos |
Chain | Residue | Details |
A | CYS415 | |
A | TRP587 | |
A | GLU592 | |
A | ARG418 | |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 3nos |
Chain | Residue | Details |
B | CYS415 | |
B | TRP587 | |
B | GLU592 | |
B | ARG418 | |