Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ZV8

A structure-based mechanism of SARS virus membrane fusion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0019031	cellular_component	viral envelope
A	0019064	biological_process	fusion of virus membrane with host plasma membrane
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0055036	cellular_component	virion membrane
A	0075509	biological_process	endocytosis involved in viral entry into host cell
B	0019064	biological_process	fusion of virus membrane with host plasma membrane
B	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0016020	cellular_component	membrane
C	0019031	cellular_component	viral envelope
C	0019064	biological_process	fusion of virus membrane with host plasma membrane
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0046813	biological_process	receptor-mediated virion attachment to host cell
C	0055036	cellular_component	virion membrane
C	0075509	biological_process	endocytosis involved in viral entry into host cell
D	0019064	biological_process	fusion of virus membrane with host plasma membrane
D	0039654	biological_process	fusion of virus membrane with host endosome membrane
E	0016020	cellular_component	membrane
E	0019031	cellular_component	viral envelope
E	0019064	biological_process	fusion of virus membrane with host plasma membrane
E	0039654	biological_process	fusion of virus membrane with host endosome membrane
E	0046813	biological_process	receptor-mediated virion attachment to host cell
E	0055036	cellular_component	virion membrane
E	0075509	biological_process	endocytosis involved in viral entry into host cell
F	0019064	biological_process	fusion of virus membrane with host plasma membrane
F	0039654	biological_process	fusion of virus membrane with host endosome membrane
G	0016020	cellular_component	membrane
G	0019031	cellular_component	viral envelope
G	0019064	biological_process	fusion of virus membrane with host plasma membrane
G	0039654	biological_process	fusion of virus membrane with host endosome membrane
G	0046813	biological_process	receptor-mediated virion attachment to host cell
G	0055036	cellular_component	virion membrane
G	0075509	biological_process	endocytosis involved in viral entry into host cell
H	0019064	biological_process	fusion of virus membrane with host plasma membrane
H	0039654	biological_process	fusion of virus membrane with host endosome membrane
I	0016020	cellular_component	membrane
I	0019031	cellular_component	viral envelope
I	0019064	biological_process	fusion of virus membrane with host plasma membrane
I	0039654	biological_process	fusion of virus membrane with host endosome membrane
I	0046813	biological_process	receptor-mediated virion attachment to host cell
I	0055036	cellular_component	virion membrane
I	0075509	biological_process	endocytosis involved in viral entry into host cell
J	0019064	biological_process	fusion of virus membrane with host plasma membrane
J	0039654	biological_process	fusion of virus membrane with host endosome membrane
K	0016020	cellular_component	membrane
K	0019031	cellular_component	viral envelope
K	0019064	biological_process	fusion of virus membrane with host plasma membrane
K	0039654	biological_process	fusion of virus membrane with host endosome membrane
K	0046813	biological_process	receptor-mediated virion attachment to host cell
K	0055036	cellular_component	virion membrane
K	0075509	biological_process	endocytosis involved in viral entry into host cell
L	0019064	biological_process	fusion of virus membrane with host plasma membrane
L	0039654	biological_process	fusion of virus membrane with host endosome membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CAC G 201

Chain	Residue
C	GLU18
L	GLN34
L	GLU35
D	ARG18
D	GLU21
G	SER50
G	ZN204
G	HOH218
H	ASP1
H	ACT202
H	ZN203

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT H 202

Chain	Residue
G	CAC201
H	ASP1
H	SER3
H	ZN203

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN H 203

Chain	Residue
C	GLU18
G	CAC201
H	ASP1
H	ACT202
H	HOH211
H	HOH212

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 204

Chain	Residue
D	GLU21
G	SER50
G	CAC201
H	ASP1
L	GLU35

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA K 205

Chain	Residue
K	GLN31
K	ASP32
K	HOH219
K	HOH220
K	HOH223

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 206

Chain	Residue
B	GLU21
F	GLU28
I	HOH64

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA J 207

Chain	Residue
E	HOH59
F	ARG18
F	GLU21
J	GLU28
J	HOH217

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA G 208

Chain	Residue
G	GLN31
G	ASP32
G	HOH213
G	HOH220
L	HOH44

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 209

Chain	Residue
A	GLU18
A	HOH215
B	ARG18
J	ASP32

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA H 210

Chain	Residue
H	ASP32
H	HOH225
H	HOH226
H	HOH229

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255\|HAMAP-Rule:MF_04099

Chain	Residue	Details
B	ASN6
J	ASN27
L	ASN6
L	ASN27
B	ASN27
D	ASN6
D	ASN27
F	ASN6
F	ASN27
H	ASN6
H	ASN27
J	ASN6

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)