1ZUM

Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005975	biological_process	carbohydrate metabolic process
A	0006066	biological_process	alcohol metabolic process
A	0006068	biological_process	ethanol catabolic process
A	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
A	0009055	molecular_function	electron transfer activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0018547	molecular_function	nitroglycerin reductase activity
A	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
A	0046185	biological_process	aldehyde catabolic process
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
A	0106435	molecular_function	carboxylesterase activity
A	1903179	biological_process	regulation of dopamine biosynthetic process
A	1905627	biological_process	regulation of serotonin biosynthetic process
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005975	biological_process	carbohydrate metabolic process
B	0006066	biological_process	alcohol metabolic process
B	0006068	biological_process	ethanol catabolic process
B	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
B	0009055	molecular_function	electron transfer activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0018547	molecular_function	nitroglycerin reductase activity
B	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
B	0046185	biological_process	aldehyde catabolic process
B	0051287	molecular_function	NAD binding
B	0070062	cellular_component	extracellular exosome
B	0106435	molecular_function	carboxylesterase activity
B	1903179	biological_process	regulation of dopamine biosynthetic process
B	1905627	biological_process	regulation of serotonin biosynthetic process
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005975	biological_process	carbohydrate metabolic process
C	0006066	biological_process	alcohol metabolic process
C	0006068	biological_process	ethanol catabolic process
C	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
C	0009055	molecular_function	electron transfer activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0018547	molecular_function	nitroglycerin reductase activity
C	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
C	0046185	biological_process	aldehyde catabolic process
C	0051287	molecular_function	NAD binding
C	0070062	cellular_component	extracellular exosome
C	0106435	molecular_function	carboxylesterase activity
C	1903179	biological_process	regulation of dopamine biosynthetic process
C	1905627	biological_process	regulation of serotonin biosynthetic process
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005975	biological_process	carbohydrate metabolic process
D	0006066	biological_process	alcohol metabolic process
D	0006068	biological_process	ethanol catabolic process
D	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
D	0009055	molecular_function	electron transfer activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0018547	molecular_function	nitroglycerin reductase activity
D	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
D	0046185	biological_process	aldehyde catabolic process
D	0051287	molecular_function	NAD binding
D	0070062	cellular_component	extracellular exosome
D	0106435	molecular_function	carboxylesterase activity
D	1903179	biological_process	regulation of dopamine biosynthetic process
D	1905627	biological_process	regulation of serotonin biosynthetic process
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005975	biological_process	carbohydrate metabolic process
E	0006066	biological_process	alcohol metabolic process
E	0006068	biological_process	ethanol catabolic process
E	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
E	0009055	molecular_function	electron transfer activity
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0018547	molecular_function	nitroglycerin reductase activity
E	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
E	0046185	biological_process	aldehyde catabolic process
E	0051287	molecular_function	NAD binding
E	0070062	cellular_component	extracellular exosome
E	0106435	molecular_function	carboxylesterase activity
E	1903179	biological_process	regulation of dopamine biosynthetic process
E	1905627	biological_process	regulation of serotonin biosynthetic process
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005975	biological_process	carbohydrate metabolic process
F	0006066	biological_process	alcohol metabolic process
F	0006068	biological_process	ethanol catabolic process
F	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
F	0009055	molecular_function	electron transfer activity
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0018547	molecular_function	nitroglycerin reductase activity
F	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
F	0046185	biological_process	aldehyde catabolic process
F	0051287	molecular_function	NAD binding
F	0070062	cellular_component	extracellular exosome
F	0106435	molecular_function	carboxylesterase activity
F	1903179	biological_process	regulation of dopamine biosynthetic process
F	1905627	biological_process	regulation of serotonin biosynthetic process
G	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
G	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005975	biological_process	carbohydrate metabolic process
G	0006066	biological_process	alcohol metabolic process
G	0006068	biological_process	ethanol catabolic process
G	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
G	0009055	molecular_function	electron transfer activity
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0018547	molecular_function	nitroglycerin reductase activity
G	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
G	0046185	biological_process	aldehyde catabolic process
G	0051287	molecular_function	NAD binding
G	0070062	cellular_component	extracellular exosome
G	0106435	molecular_function	carboxylesterase activity
G	1903179	biological_process	regulation of dopamine biosynthetic process
G	1905627	biological_process	regulation of serotonin biosynthetic process
H	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
H	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005975	biological_process	carbohydrate metabolic process
H	0006066	biological_process	alcohol metabolic process
H	0006068	biological_process	ethanol catabolic process
H	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
H	0009055	molecular_function	electron transfer activity
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0018547	molecular_function	nitroglycerin reductase activity
H	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
H	0046185	biological_process	aldehyde catabolic process
H	0051287	molecular_function	NAD binding
H	0070062	cellular_component	extracellular exosome
H	0106435	molecular_function	carboxylesterase activity
H	1903179	biological_process	regulation of dopamine biosynthetic process
H	1905627	biological_process	regulation of serotonin biosynthetic process
I	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
I	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005975	biological_process	carbohydrate metabolic process
I	0006066	biological_process	alcohol metabolic process
I	0006068	biological_process	ethanol catabolic process
I	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
I	0009055	molecular_function	electron transfer activity
I	0016491	molecular_function	oxidoreductase activity
I	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
I	0018547	molecular_function	nitroglycerin reductase activity
I	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
I	0046185	biological_process	aldehyde catabolic process
I	0051287	molecular_function	NAD binding
I	0070062	cellular_component	extracellular exosome
I	0106435	molecular_function	carboxylesterase activity
I	1903179	biological_process	regulation of dopamine biosynthetic process
I	1905627	biological_process	regulation of serotonin biosynthetic process
J	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
J	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0005975	biological_process	carbohydrate metabolic process
J	0006066	biological_process	alcohol metabolic process
J	0006068	biological_process	ethanol catabolic process
J	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
J	0009055	molecular_function	electron transfer activity
J	0016491	molecular_function	oxidoreductase activity
J	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
J	0018547	molecular_function	nitroglycerin reductase activity
J	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
J	0046185	biological_process	aldehyde catabolic process
J	0051287	molecular_function	NAD binding
J	0070062	cellular_component	extracellular exosome
J	0106435	molecular_function	carboxylesterase activity
J	1903179	biological_process	regulation of dopamine biosynthetic process
J	1905627	biological_process	regulation of serotonin biosynthetic process
K	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
K	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005975	biological_process	carbohydrate metabolic process
K	0006066	biological_process	alcohol metabolic process
K	0006068	biological_process	ethanol catabolic process
K	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
K	0009055	molecular_function	electron transfer activity
K	0016491	molecular_function	oxidoreductase activity
K	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
K	0018547	molecular_function	nitroglycerin reductase activity
K	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
K	0046185	biological_process	aldehyde catabolic process
K	0051287	molecular_function	NAD binding
K	0070062	cellular_component	extracellular exosome
K	0106435	molecular_function	carboxylesterase activity
K	1903179	biological_process	regulation of dopamine biosynthetic process
K	1905627	biological_process	regulation of serotonin biosynthetic process
L	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
L	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0005975	biological_process	carbohydrate metabolic process
L	0006066	biological_process	alcohol metabolic process
L	0006068	biological_process	ethanol catabolic process
L	0008957	molecular_function	phenylacetaldehyde dehydrogenase activity
L	0009055	molecular_function	electron transfer activity
L	0016491	molecular_function	oxidoreductase activity
L	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
L	0018547	molecular_function	nitroglycerin reductase activity
L	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
L	0046185	biological_process	aldehyde catabolic process
L	0051287	molecular_function	NAD binding
L	0070062	cellular_component	extracellular exosome
L	0106435	molecular_function	carboxylesterase activity
L	1903179	biological_process	regulation of dopamine biosynthetic process
L	1905627	biological_process	regulation of serotonin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 3701

Chain	Residue
A	THR39
A	VAL40
A	ASP109
A	GLN196
A	HOH3851

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 3702

Chain	Residue
B	HOH3783
B	THR39
B	VAL40
B	ASP109
B	GLN196

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 3703

Chain	Residue
C	THR39
C	VAL40
C	ASP109
C	GLN196
C	HOH3902
C	HOH3903

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 3704

Chain	Residue
D	THR39
D	VAL40
D	ASP109
D	GLN196
D	HOH3796
D	HOH3840

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA E 3705

Chain	Residue
E	THR39
E	VAL40
E	ASP109
E	GLN196
E	HOH3904

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA F 3706

Chain	Residue
F	THR39
F	VAL40
F	ASP109
F	GLN196
F	HOH3794
F	HOH3883

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA G 3707

Chain	Residue
G	THR39
G	VAL40
G	ASP109
G	GLN196
G	HOH3949

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA H 3708

Chain	Residue
H	THR39
H	VAL40
H	ASP109
H	GLN196
H	HOH3910

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA I 3709

Chain	Residue
I	THR39
I	VAL40
I	ASP109
I	GLN196
I	HOH3832
I	HOH3833

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA J 3710

Chain	Residue
J	THR39
J	VAL40
J	ASP109
J	GLN196
J	HOH3781

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA K 3711

Chain	Residue
K	THR39
K	VAL40
K	ASP109
K	GLN196
K	HOH3769

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA L 3712

Chain	Residue
L	THR39
L	VAL40
L	ASP109
L	GLN196
L	HOH3785

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI A 3101

Chain	Residue
A	ILE146
A	ASP147
A	PHE150
A	HOH3727
B	PHE459

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI E 3102

Chain	Residue
E	ASP147
E	PHE150
E	HOH3954
F	PHE459
F	HOH4012

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI F 3103

Chain	Residue
F	PHE70
F	GLU157
F	PRO158
F	VAL159
F	LYS487

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GAI F 3104

Chain	Residue
E	PHE459
F	ASP147
F	PHE150

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI G 3105

Chain	Residue
G	ILE146
G	ASP147
G	PHE150
G	HOH3861
H	PHE459

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI H 3106

Chain	Residue
G	PHE459
G	HOH3848
H	ILE146
H	ASP147
H	PHE150

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI I 3107

Chain	Residue
I	ILE146
I	ASP147
I	PHE150
I	HOH3712
J	PHE459

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI L 3108

Chain	Residue
L	VAL458
L	PHE459
L	GLY460
K	ILE146
K	ASP147

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 3109

Chain	Residue
A	TYR153
A	ARG155
B	SER443
D	PHE151

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 3110

Chain	Residue
A	ASN41
A	THR44
A	GLU46
A	LEU108

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 3111

Chain	Residue
A	PHE18
A	TYR101
A	TYR203

---

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 3112

Chain	Residue
B	ASN41
B	THR44
B	LEU108
B	HOH3896
B	HOH3949

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 3113

Chain	Residue
B	PHE151
C	TYR153
C	ARG155
D	SER443

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 3114

Chain	Residue
C	ASN41
C	THR44
C	GLU46
C	VAL47
C	LEU108
C	HOH3896

---

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 3115

Chain	Residue
C	PHE18
C	TYR101
C	TYR203
C	HOH3849

---

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 3116

Chain	Residue
A	PHE151
C	SER443
C	GLN444
D	TYR153
D	ARG155

---

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 3117

Chain	Residue
D	GLN14
D	ASN41
D	THR44
D	GLU46
D	VAL47

---

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 3118

Chain	Residue
E	ASN41
E	THR44
E	GLU46
E	VAL47
E	LEU108

---

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO I 3119

Chain	Residue
E	PHE18
E	TYR101
E	TYR203
I	GLN14
I	HOH3802

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO F 3120

Chain	Residue
E	SER443
F	TYR153
F	ARG155
G	PHE151

---

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO F 3121

Chain	Residue
F	GLN14
F	ASN41
F	THR44
F	GLU46
F	VAL47

---

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO F 3122

Chain	Residue
F	PHE18
F	TYR101
F	TYR203
F	HOH3798

---

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 3123

Chain	Residue
F	PHE151
G	TYR153
G	ARG155
H	SER443

---

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO G 3124

Chain	Residue
G	GLN14
G	ASN41
G	THR44
G	GLU46
G	VAL47
G	LEU108

---

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO G 3125

Chain	Residue
G	TYR101
G	TYR203
G	HOH3810

---

site_id	EC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 3126

Chain	Residue
D	LYS361
D	LEU367
D	HOH3734
D	HOH3759
H	PHE18
H	TYR101
H	TYR203

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO I 3127

Chain	Residue
I	PHE18
I	TYR101
I	TYR203
I	HOH3734

---

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO J 3128

Chain	Residue
J	GLN14
J	ASN41
J	THR44
J	GLU46

---

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO L 3129

Chain	Residue
K	SER443
L	TYR153
L	ARG155

---

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCCAGS

Chain	Residue	Details
A	PHE295-SER306

---

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU267-PRO274

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	GLU268
J	GLU268
K	GLU268
L	GLU268
B	GLU268
C	GLU268
D	GLU268
E	GLU268
F	GLU268
G	GLU268
H	GLU268
I	GLU268

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
A	CYS302
J	CYS302
K	CYS302
L	CYS302
B	CYS302
C	CYS302
D	CYS302
E	CYS302
F	CYS302
G	CYS302
H	CYS302
I	CYS302

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY245
J	GLY245
K	GLY245
L	GLY245
B	GLY245
C	GLY245
D	GLY245
E	GLY245
F	GLY245
G	GLY245
H	GLY245
I	GLY245

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P20000

Chain	Residue	Details
A	ASN169
J	ASN169
K	ASN169
L	ASN169
B	ASN169
C	ASN169
D	ASN169
E	ASN169
F	ASN169
G	ASN169
H	ASN169
I	ASN169

---

site_id	SWS_FT_FI5
Number of Residues	108
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P47738

Chain	Residue	Details
A	LYS35
B	LYS35
L	LYS35
L	LYS56
L	LYS61
L	LYS142
L	LYS351
L	LYS366
L	LYS409
L	LYS411
L	LYS434
B	LYS56
B	LYS61
B	LYS142
B	LYS351
B	LYS366
B	LYS409
B	LYS411
B	LYS434
C	LYS35
A	LYS56
C	LYS56
C	LYS61
C	LYS142
C	LYS351
C	LYS366
C	LYS409
C	LYS411
C	LYS434
D	LYS35
D	LYS56
A	LYS61
D	LYS61
D	LYS142
D	LYS351
D	LYS366
D	LYS409
D	LYS411
D	LYS434
E	LYS35
E	LYS56
E	LYS61
A	LYS142
E	LYS142
E	LYS351
E	LYS366
E	LYS409
E	LYS411
E	LYS434
F	LYS35
F	LYS56
F	LYS61
F	LYS142
A	LYS351
F	LYS351
F	LYS366
F	LYS409
F	LYS411
F	LYS434
G	LYS35
G	LYS56
G	LYS61
G	LYS142
G	LYS351
A	LYS366
G	LYS366
G	LYS409
G	LYS411
G	LYS434
H	LYS35
H	LYS56
H	LYS61
H	LYS142
H	LYS351
H	LYS366
A	LYS409
H	LYS409
H	LYS411
H	LYS434
I	LYS35
I	LYS56
I	LYS61
I	LYS142
I	LYS351
I	LYS366
I	LYS409
A	LYS411
I	LYS411
I	LYS434
J	LYS35
J	LYS56
J	LYS61
J	LYS142
J	LYS351
J	LYS366
J	LYS409
J	LYS411
A	LYS434
J	LYS434
K	LYS35
K	LYS56
K	LYS61
K	LYS142
K	LYS351
K	LYS366
K	LYS409
K	LYS411
K	LYS434

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
A	LYS192	electrostatic stabiliser
A	GLU268	electrostatic stabiliser, proton acceptor, proton donor
A	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
A	GLU399	electrostatic stabiliser

---

site_id	MCSA10
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
J	LYS192	electrostatic stabiliser
J	GLU268	electrostatic stabiliser, proton acceptor, proton donor
J	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
J	GLU399	electrostatic stabiliser

---

site_id	MCSA11
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
K	LYS192	electrostatic stabiliser
K	GLU268	electrostatic stabiliser, proton acceptor, proton donor
K	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
K	GLU399	electrostatic stabiliser

---

site_id	MCSA12
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
L	LYS192	electrostatic stabiliser
L	GLU268	electrostatic stabiliser, proton acceptor, proton donor
L	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
L	GLU399	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
B	LYS192	electrostatic stabiliser
B	GLU268	electrostatic stabiliser, proton acceptor, proton donor
B	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
B	GLU399	electrostatic stabiliser

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
C	LYS192	electrostatic stabiliser
C	GLU268	electrostatic stabiliser, proton acceptor, proton donor
C	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
C	GLU399	electrostatic stabiliser

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
D	LYS192	electrostatic stabiliser
D	GLU268	electrostatic stabiliser, proton acceptor, proton donor
D	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
D	GLU399	electrostatic stabiliser

---

site_id	MCSA5
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
E	LYS192	electrostatic stabiliser
E	GLU268	electrostatic stabiliser, proton acceptor, proton donor
E	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
E	GLU399	electrostatic stabiliser

---

site_id	MCSA6
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
F	LYS192	electrostatic stabiliser
F	GLU268	electrostatic stabiliser, proton acceptor, proton donor
F	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
F	GLU399	electrostatic stabiliser

---

site_id	MCSA7
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
G	LYS192	electrostatic stabiliser
G	GLU268	electrostatic stabiliser, proton acceptor, proton donor
G	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
G	GLU399	electrostatic stabiliser

---

site_id	MCSA8
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
H	LYS192	electrostatic stabiliser
H	GLU268	electrostatic stabiliser, proton acceptor, proton donor
H	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
H	GLU399	electrostatic stabiliser

---

site_id	MCSA9
Number of Residues	4
Details	M-CSA 803

Chain	Residue	Details
I	LYS192	electrostatic stabiliser
I	GLU268	electrostatic stabiliser, proton acceptor, proton donor
I	CYS302	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
I	GLU399	electrostatic stabiliser

---