1ZUM
Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
A | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006066 | biological_process | alcohol metabolic process |
A | 0006068 | biological_process | ethanol catabolic process |
A | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
A | 0009055 | molecular_function | electron transfer activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
A | 0018937 | biological_process | nitroglycerin metabolic process |
A | 0046185 | biological_process | aldehyde catabolic process |
A | 0051287 | molecular_function | NAD binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0106435 | molecular_function | carboxylesterase activity |
A | 1903179 | biological_process | regulation of dopamine biosynthetic process |
A | 1905627 | biological_process | regulation of serotonin biosynthetic process |
B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
B | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006066 | biological_process | alcohol metabolic process |
B | 0006068 | biological_process | ethanol catabolic process |
B | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
B | 0009055 | molecular_function | electron transfer activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0018937 | biological_process | nitroglycerin metabolic process |
B | 0046185 | biological_process | aldehyde catabolic process |
B | 0051287 | molecular_function | NAD binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0106435 | molecular_function | carboxylesterase activity |
B | 1903179 | biological_process | regulation of dopamine biosynthetic process |
B | 1905627 | biological_process | regulation of serotonin biosynthetic process |
C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
C | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
C | 0005739 | cellular_component | mitochondrion |
C | 0005759 | cellular_component | mitochondrial matrix |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0006066 | biological_process | alcohol metabolic process |
C | 0006068 | biological_process | ethanol catabolic process |
C | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
C | 0009055 | molecular_function | electron transfer activity |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
C | 0018937 | biological_process | nitroglycerin metabolic process |
C | 0046185 | biological_process | aldehyde catabolic process |
C | 0051287 | molecular_function | NAD binding |
C | 0070062 | cellular_component | extracellular exosome |
C | 0106435 | molecular_function | carboxylesterase activity |
C | 1903179 | biological_process | regulation of dopamine biosynthetic process |
C | 1905627 | biological_process | regulation of serotonin biosynthetic process |
D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
D | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
D | 0005739 | cellular_component | mitochondrion |
D | 0005759 | cellular_component | mitochondrial matrix |
D | 0005975 | biological_process | carbohydrate metabolic process |
D | 0006066 | biological_process | alcohol metabolic process |
D | 0006068 | biological_process | ethanol catabolic process |
D | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
D | 0009055 | molecular_function | electron transfer activity |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
D | 0018937 | biological_process | nitroglycerin metabolic process |
D | 0046185 | biological_process | aldehyde catabolic process |
D | 0051287 | molecular_function | NAD binding |
D | 0070062 | cellular_component | extracellular exosome |
D | 0106435 | molecular_function | carboxylesterase activity |
D | 1903179 | biological_process | regulation of dopamine biosynthetic process |
D | 1905627 | biological_process | regulation of serotonin biosynthetic process |
E | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
E | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
E | 0005739 | cellular_component | mitochondrion |
E | 0005759 | cellular_component | mitochondrial matrix |
E | 0005975 | biological_process | carbohydrate metabolic process |
E | 0006066 | biological_process | alcohol metabolic process |
E | 0006068 | biological_process | ethanol catabolic process |
E | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
E | 0009055 | molecular_function | electron transfer activity |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
E | 0018937 | biological_process | nitroglycerin metabolic process |
E | 0046185 | biological_process | aldehyde catabolic process |
E | 0051287 | molecular_function | NAD binding |
E | 0070062 | cellular_component | extracellular exosome |
E | 0106435 | molecular_function | carboxylesterase activity |
E | 1903179 | biological_process | regulation of dopamine biosynthetic process |
E | 1905627 | biological_process | regulation of serotonin biosynthetic process |
F | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
F | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
F | 0005739 | cellular_component | mitochondrion |
F | 0005759 | cellular_component | mitochondrial matrix |
F | 0005975 | biological_process | carbohydrate metabolic process |
F | 0006066 | biological_process | alcohol metabolic process |
F | 0006068 | biological_process | ethanol catabolic process |
F | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
F | 0009055 | molecular_function | electron transfer activity |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
F | 0018937 | biological_process | nitroglycerin metabolic process |
F | 0046185 | biological_process | aldehyde catabolic process |
F | 0051287 | molecular_function | NAD binding |
F | 0070062 | cellular_component | extracellular exosome |
F | 0106435 | molecular_function | carboxylesterase activity |
F | 1903179 | biological_process | regulation of dopamine biosynthetic process |
F | 1905627 | biological_process | regulation of serotonin biosynthetic process |
G | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
G | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
G | 0005739 | cellular_component | mitochondrion |
G | 0005759 | cellular_component | mitochondrial matrix |
G | 0005975 | biological_process | carbohydrate metabolic process |
G | 0006066 | biological_process | alcohol metabolic process |
G | 0006068 | biological_process | ethanol catabolic process |
G | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
G | 0009055 | molecular_function | electron transfer activity |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
G | 0018937 | biological_process | nitroglycerin metabolic process |
G | 0046185 | biological_process | aldehyde catabolic process |
G | 0051287 | molecular_function | NAD binding |
G | 0070062 | cellular_component | extracellular exosome |
G | 0106435 | molecular_function | carboxylesterase activity |
G | 1903179 | biological_process | regulation of dopamine biosynthetic process |
G | 1905627 | biological_process | regulation of serotonin biosynthetic process |
H | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
H | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
H | 0005739 | cellular_component | mitochondrion |
H | 0005759 | cellular_component | mitochondrial matrix |
H | 0005975 | biological_process | carbohydrate metabolic process |
H | 0006066 | biological_process | alcohol metabolic process |
H | 0006068 | biological_process | ethanol catabolic process |
H | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
H | 0009055 | molecular_function | electron transfer activity |
H | 0016491 | molecular_function | oxidoreductase activity |
H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
H | 0018937 | biological_process | nitroglycerin metabolic process |
H | 0046185 | biological_process | aldehyde catabolic process |
H | 0051287 | molecular_function | NAD binding |
H | 0070062 | cellular_component | extracellular exosome |
H | 0106435 | molecular_function | carboxylesterase activity |
H | 1903179 | biological_process | regulation of dopamine biosynthetic process |
H | 1905627 | biological_process | regulation of serotonin biosynthetic process |
I | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
I | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
I | 0005739 | cellular_component | mitochondrion |
I | 0005759 | cellular_component | mitochondrial matrix |
I | 0005975 | biological_process | carbohydrate metabolic process |
I | 0006066 | biological_process | alcohol metabolic process |
I | 0006068 | biological_process | ethanol catabolic process |
I | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
I | 0009055 | molecular_function | electron transfer activity |
I | 0016491 | molecular_function | oxidoreductase activity |
I | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
I | 0018937 | biological_process | nitroglycerin metabolic process |
I | 0046185 | biological_process | aldehyde catabolic process |
I | 0051287 | molecular_function | NAD binding |
I | 0070062 | cellular_component | extracellular exosome |
I | 0106435 | molecular_function | carboxylesterase activity |
I | 1903179 | biological_process | regulation of dopamine biosynthetic process |
I | 1905627 | biological_process | regulation of serotonin biosynthetic process |
J | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
J | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
J | 0005739 | cellular_component | mitochondrion |
J | 0005759 | cellular_component | mitochondrial matrix |
J | 0005975 | biological_process | carbohydrate metabolic process |
J | 0006066 | biological_process | alcohol metabolic process |
J | 0006068 | biological_process | ethanol catabolic process |
J | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
J | 0009055 | molecular_function | electron transfer activity |
J | 0016491 | molecular_function | oxidoreductase activity |
J | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
J | 0018937 | biological_process | nitroglycerin metabolic process |
J | 0046185 | biological_process | aldehyde catabolic process |
J | 0051287 | molecular_function | NAD binding |
J | 0070062 | cellular_component | extracellular exosome |
J | 0106435 | molecular_function | carboxylesterase activity |
J | 1903179 | biological_process | regulation of dopamine biosynthetic process |
J | 1905627 | biological_process | regulation of serotonin biosynthetic process |
K | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
K | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
K | 0005739 | cellular_component | mitochondrion |
K | 0005759 | cellular_component | mitochondrial matrix |
K | 0005975 | biological_process | carbohydrate metabolic process |
K | 0006066 | biological_process | alcohol metabolic process |
K | 0006068 | biological_process | ethanol catabolic process |
K | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
K | 0009055 | molecular_function | electron transfer activity |
K | 0016491 | molecular_function | oxidoreductase activity |
K | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
K | 0018937 | biological_process | nitroglycerin metabolic process |
K | 0046185 | biological_process | aldehyde catabolic process |
K | 0051287 | molecular_function | NAD binding |
K | 0070062 | cellular_component | extracellular exosome |
K | 0106435 | molecular_function | carboxylesterase activity |
K | 1903179 | biological_process | regulation of dopamine biosynthetic process |
K | 1905627 | biological_process | regulation of serotonin biosynthetic process |
L | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
L | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
L | 0005739 | cellular_component | mitochondrion |
L | 0005759 | cellular_component | mitochondrial matrix |
L | 0005975 | biological_process | carbohydrate metabolic process |
L | 0006066 | biological_process | alcohol metabolic process |
L | 0006068 | biological_process | ethanol catabolic process |
L | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase (NAD+) activity |
L | 0009055 | molecular_function | electron transfer activity |
L | 0016491 | molecular_function | oxidoreductase activity |
L | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
L | 0018937 | biological_process | nitroglycerin metabolic process |
L | 0046185 | biological_process | aldehyde catabolic process |
L | 0051287 | molecular_function | NAD binding |
L | 0070062 | cellular_component | extracellular exosome |
L | 0106435 | molecular_function | carboxylesterase activity |
L | 1903179 | biological_process | regulation of dopamine biosynthetic process |
L | 1905627 | biological_process | regulation of serotonin biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA A 3701 |
Chain | Residue |
A | THR39 |
A | VAL40 |
A | ASP109 |
A | GLN196 |
A | HOH3851 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA B 3702 |
Chain | Residue |
B | HOH3783 |
B | THR39 |
B | VAL40 |
B | ASP109 |
B | GLN196 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA C 3703 |
Chain | Residue |
C | THR39 |
C | VAL40 |
C | ASP109 |
C | GLN196 |
C | HOH3902 |
C | HOH3903 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA D 3704 |
Chain | Residue |
D | THR39 |
D | VAL40 |
D | ASP109 |
D | GLN196 |
D | HOH3796 |
D | HOH3840 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA E 3705 |
Chain | Residue |
E | THR39 |
E | VAL40 |
E | ASP109 |
E | GLN196 |
E | HOH3904 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA F 3706 |
Chain | Residue |
F | THR39 |
F | VAL40 |
F | ASP109 |
F | GLN196 |
F | HOH3794 |
F | HOH3883 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA G 3707 |
Chain | Residue |
G | THR39 |
G | VAL40 |
G | ASP109 |
G | GLN196 |
G | HOH3949 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA H 3708 |
Chain | Residue |
H | THR39 |
H | VAL40 |
H | ASP109 |
H | GLN196 |
H | HOH3910 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA I 3709 |
Chain | Residue |
I | THR39 |
I | VAL40 |
I | ASP109 |
I | GLN196 |
I | HOH3832 |
I | HOH3833 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA J 3710 |
Chain | Residue |
J | THR39 |
J | VAL40 |
J | ASP109 |
J | GLN196 |
J | HOH3781 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA K 3711 |
Chain | Residue |
K | THR39 |
K | VAL40 |
K | ASP109 |
K | GLN196 |
K | HOH3769 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA L 3712 |
Chain | Residue |
L | THR39 |
L | VAL40 |
L | ASP109 |
L | GLN196 |
L | HOH3785 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GAI A 3101 |
Chain | Residue |
A | ILE146 |
A | ASP147 |
A | PHE150 |
A | HOH3727 |
B | PHE459 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GAI E 3102 |
Chain | Residue |
E | ASP147 |
E | PHE150 |
E | HOH3954 |
F | PHE459 |
F | HOH4012 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GAI F 3103 |
Chain | Residue |
F | PHE70 |
F | GLU157 |
F | PRO158 |
F | VAL159 |
F | LYS487 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GAI F 3104 |
Chain | Residue |
E | PHE459 |
F | ASP147 |
F | PHE150 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GAI G 3105 |
Chain | Residue |
G | ILE146 |
G | ASP147 |
G | PHE150 |
G | HOH3861 |
H | PHE459 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GAI H 3106 |
Chain | Residue |
G | PHE459 |
G | HOH3848 |
H | ILE146 |
H | ASP147 |
H | PHE150 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GAI I 3107 |
Chain | Residue |
I | ILE146 |
I | ASP147 |
I | PHE150 |
I | HOH3712 |
J | PHE459 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GAI L 3108 |
Chain | Residue |
L | VAL458 |
L | PHE459 |
L | GLY460 |
K | ILE146 |
K | ASP147 |
site_id | CC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 3109 |
Chain | Residue |
A | TYR153 |
A | ARG155 |
B | SER443 |
D | PHE151 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 3110 |
Chain | Residue |
A | ASN41 |
A | THR44 |
A | GLU46 |
A | LEU108 |
site_id | CC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 3111 |
Chain | Residue |
A | PHE18 |
A | TYR101 |
A | TYR203 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 3112 |
Chain | Residue |
B | ASN41 |
B | THR44 |
B | LEU108 |
B | HOH3896 |
B | HOH3949 |
site_id | CC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO C 3113 |
Chain | Residue |
B | PHE151 |
C | TYR153 |
C | ARG155 |
D | SER443 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO C 3114 |
Chain | Residue |
C | ASN41 |
C | THR44 |
C | GLU46 |
C | VAL47 |
C | LEU108 |
C | HOH3896 |
site_id | CC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO C 3115 |
Chain | Residue |
C | PHE18 |
C | TYR101 |
C | TYR203 |
C | HOH3849 |
site_id | DC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 3116 |
Chain | Residue |
A | PHE151 |
C | SER443 |
C | GLN444 |
D | TYR153 |
D | ARG155 |
site_id | DC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO D 3117 |
Chain | Residue |
D | GLN14 |
D | ASN41 |
D | THR44 |
D | GLU46 |
D | VAL47 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO E 3118 |
Chain | Residue |
E | ASN41 |
E | THR44 |
E | GLU46 |
E | VAL47 |
E | LEU108 |
site_id | DC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO I 3119 |
Chain | Residue |
E | PHE18 |
E | TYR101 |
E | TYR203 |
I | GLN14 |
I | HOH3802 |
site_id | DC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO F 3120 |
Chain | Residue |
E | SER443 |
F | TYR153 |
F | ARG155 |
G | PHE151 |
site_id | DC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO F 3121 |
Chain | Residue |
F | GLN14 |
F | ASN41 |
F | THR44 |
F | GLU46 |
F | VAL47 |
site_id | DC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO F 3122 |
Chain | Residue |
F | PHE18 |
F | TYR101 |
F | TYR203 |
F | HOH3798 |
site_id | DC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO G 3123 |
Chain | Residue |
F | PHE151 |
G | TYR153 |
G | ARG155 |
H | SER443 |
site_id | DC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO G 3124 |
Chain | Residue |
G | GLN14 |
G | ASN41 |
G | THR44 |
G | GLU46 |
G | VAL47 |
G | LEU108 |
site_id | EC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO G 3125 |
Chain | Residue |
G | TYR101 |
G | TYR203 |
G | HOH3810 |
site_id | EC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO D 3126 |
Chain | Residue |
D | LYS361 |
D | LEU367 |
D | HOH3734 |
D | HOH3759 |
H | PHE18 |
H | TYR101 |
H | TYR203 |
site_id | EC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO I 3127 |
Chain | Residue |
I | PHE18 |
I | TYR101 |
I | TYR203 |
I | HOH3734 |
site_id | EC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO J 3128 |
Chain | Residue |
J | GLN14 |
J | ASN41 |
J | THR44 |
J | GLU46 |
site_id | EC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO L 3129 |
Chain | Residue |
K | SER443 |
L | TYR153 |
L | ARG155 |
Functional Information from PROSITE/UniProt
site_id | PS00070 |
Number of Residues | 12 |
Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCCAGS |
Chain | Residue | Details |
A | PHE295-SER306 |
site_id | PS00687 |
Number of Residues | 8 |
Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP |
Chain | Residue | Details |
A | LEU267-PRO274 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | GLU268 | |
J | GLU268 | |
K | GLU268 | |
L | GLU268 | |
B | GLU268 | |
C | GLU268 | |
D | GLU268 | |
E | GLU268 | |
F | GLU268 | |
G | GLU268 | |
H | GLU268 | |
I | GLU268 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
A | CYS302 | |
J | CYS302 | |
K | CYS302 | |
L | CYS302 | |
B | CYS302 | |
C | CYS302 | |
D | CYS302 | |
E | CYS302 | |
F | CYS302 | |
G | CYS302 | |
H | CYS302 | |
I | CYS302 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | GLY245 | |
J | GLY245 | |
K | GLY245 | |
L | GLY245 | |
B | GLY245 | |
C | GLY245 | |
D | GLY245 | |
E | GLY245 | |
F | GLY245 | |
G | GLY245 | |
H | GLY245 | |
I | GLY245 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P20000 |
Chain | Residue | Details |
A | ASN169 | |
J | ASN169 | |
K | ASN169 | |
L | ASN169 | |
B | ASN169 | |
C | ASN169 | |
D | ASN169 | |
E | ASN169 | |
F | ASN169 | |
G | ASN169 | |
H | ASN169 | |
I | ASN169 |
site_id | SWS_FT_FI5 |
Number of Residues | 108 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P47738 |
Chain | Residue | Details |
A | LYS35 | |
B | LYS35 | |
L | LYS35 | |
L | LYS56 | |
L | LYS61 | |
L | LYS142 | |
L | LYS351 | |
L | LYS366 | |
L | LYS409 | |
L | LYS411 | |
L | LYS434 | |
B | LYS56 | |
B | LYS61 | |
B | LYS142 | |
B | LYS351 | |
B | LYS366 | |
B | LYS409 | |
B | LYS411 | |
B | LYS434 | |
C | LYS35 | |
A | LYS56 | |
C | LYS56 | |
C | LYS61 | |
C | LYS142 | |
C | LYS351 | |
C | LYS366 | |
C | LYS409 | |
C | LYS411 | |
C | LYS434 | |
D | LYS35 | |
D | LYS56 | |
A | LYS61 | |
D | LYS61 | |
D | LYS142 | |
D | LYS351 | |
D | LYS366 | |
D | LYS409 | |
D | LYS411 | |
D | LYS434 | |
E | LYS35 | |
E | LYS56 | |
E | LYS61 | |
A | LYS142 | |
E | LYS142 | |
E | LYS351 | |
E | LYS366 | |
E | LYS409 | |
E | LYS411 | |
E | LYS434 | |
F | LYS35 | |
F | LYS56 | |
F | LYS61 | |
F | LYS142 | |
A | LYS351 | |
F | LYS351 | |
F | LYS366 | |
F | LYS409 | |
F | LYS411 | |
F | LYS434 | |
G | LYS35 | |
G | LYS56 | |
G | LYS61 | |
G | LYS142 | |
G | LYS351 | |
A | LYS366 | |
G | LYS366 | |
G | LYS409 | |
G | LYS411 | |
G | LYS434 | |
H | LYS35 | |
H | LYS56 | |
H | LYS61 | |
H | LYS142 | |
H | LYS351 | |
H | LYS366 | |
A | LYS409 | |
H | LYS409 | |
H | LYS411 | |
H | LYS434 | |
I | LYS35 | |
I | LYS56 | |
I | LYS61 | |
I | LYS142 | |
I | LYS351 | |
I | LYS366 | |
I | LYS409 | |
A | LYS411 | |
I | LYS411 | |
I | LYS434 | |
J | LYS35 | |
J | LYS56 | |
J | LYS61 | |
J | LYS142 | |
J | LYS351 | |
J | LYS366 | |
J | LYS409 | |
J | LYS411 | |
A | LYS434 | |
J | LYS434 | |
K | LYS35 | |
K | LYS56 | |
K | LYS61 | |
K | LYS142 | |
K | LYS351 | |
K | LYS366 | |
K | LYS409 | |
K | LYS411 | |
K | LYS434 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
A | CYS302 | |
A | GLU268 | |
A | ASN169 |
site_id | CSA10 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
J | CYS302 | |
J | GLU268 | |
J | ASN169 |
site_id | CSA11 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
K | CYS302 | |
K | ASN169 |
site_id | CSA12 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
L | CYS302 | |
L | GLU268 | |
L | ASN169 |
site_id | CSA13 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
A | CYS302 | |
A | LYS192 | |
A | GLU268 | |
A | GLU399 |
site_id | CSA14 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
B | CYS302 | |
B | LYS192 | |
B | GLU268 | |
B | GLU399 |
site_id | CSA15 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
C | CYS302 | |
C | LYS192 | |
C | GLU268 | |
C | GLU399 |
site_id | CSA16 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
D | CYS302 | |
D | LYS192 | |
D | GLU268 | |
D | GLU399 |
site_id | CSA17 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
E | CYS302 | |
E | LYS192 | |
E | GLU268 | |
E | GLU399 |
site_id | CSA18 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
F | CYS302 | |
F | LYS192 | |
F | GLU268 | |
F | GLU399 |
site_id | CSA19 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
G | CYS302 | |
G | LYS192 | |
G | GLU268 | |
G | GLU399 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
B | CYS302 | |
B | GLU268 | |
B | ASN169 |
site_id | CSA20 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
H | CYS302 | |
H | LYS192 | |
H | GLU268 | |
H | GLU399 |
site_id | CSA21 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
I | CYS302 | |
I | LYS192 | |
I | GLU268 | |
I | GLU399 |
site_id | CSA22 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
J | CYS302 | |
J | LYS192 | |
J | GLU268 | |
J | GLU399 |
site_id | CSA23 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
L | CYS302 | |
L | LYS192 | |
L | GLU268 | |
L | GLU399 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
C | CYS302 | |
C | GLU268 | |
C | ASN169 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
D | CYS302 | |
D | GLU268 | |
D | ASN169 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
E | CYS302 | |
E | GLU268 | |
E | ASN169 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
F | CYS302 | |
F | GLU268 | |
F | ASN169 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
G | CYS302 | |
G | GLU268 | |
G | ASN169 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
H | CYS302 | |
H | GLU268 | |
H | ASN169 |
site_id | CSA9 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4s |
Chain | Residue | Details |
I | CYS302 | |
I | GLU268 | |
I | ASN169 |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
A | LYS192 | electrostatic stabiliser |
A | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
A | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
A | GLU399 | electrostatic stabiliser |
site_id | MCSA10 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
J | LYS192 | electrostatic stabiliser |
J | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
J | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
J | GLU399 | electrostatic stabiliser |
site_id | MCSA11 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
K | LYS192 | electrostatic stabiliser |
K | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
K | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
K | GLU399 | electrostatic stabiliser |
site_id | MCSA12 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
L | LYS192 | electrostatic stabiliser |
L | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
L | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
L | GLU399 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
B | LYS192 | electrostatic stabiliser |
B | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
B | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
B | GLU399 | electrostatic stabiliser |
site_id | MCSA3 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
C | LYS192 | electrostatic stabiliser |
C | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
C | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
C | GLU399 | electrostatic stabiliser |
site_id | MCSA4 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
D | LYS192 | electrostatic stabiliser |
D | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
D | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
D | GLU399 | electrostatic stabiliser |
site_id | MCSA5 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
E | LYS192 | electrostatic stabiliser |
E | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
E | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
E | GLU399 | electrostatic stabiliser |
site_id | MCSA6 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
F | LYS192 | electrostatic stabiliser |
F | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
F | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
F | GLU399 | electrostatic stabiliser |
site_id | MCSA7 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
G | LYS192 | electrostatic stabiliser |
G | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
G | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
G | GLU399 | electrostatic stabiliser |
site_id | MCSA8 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
H | LYS192 | electrostatic stabiliser |
H | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
H | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
H | GLU399 | electrostatic stabiliser |
site_id | MCSA9 |
Number of Residues | 4 |
Details | M-CSA 803 |
Chain | Residue | Details |
I | LYS192 | electrostatic stabiliser |
I | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
I | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
I | GLU399 | electrostatic stabiliser |