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1ZS8

Crystal Structure of the Murine MHC Class Ib Molecule M10.5

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
A0016020cellular_componentmembrane
A0030670cellular_componentphagocytic vesicle membrane
A0042612cellular_componentMHC class I protein complex
A0098553cellular_componentlumenal side of endoplasmic reticulum membrane
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010038biological_processresponse to metal ion
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0033077biological_processT cell differentiation in thymus
B0033572biological_processtransferrin transport
B0034756biological_processregulation of iron ion transport
B0034757biological_processnegative regulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
C0002376biological_processimmune system process
C0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
C0016020cellular_componentmembrane
C0030670cellular_componentphagocytic vesicle membrane
C0042612cellular_componentMHC class I protein complex
C0098553cellular_componentlumenal side of endoplasmic reticulum membrane
D0000139cellular_componentGolgi membrane
D0001913biological_processT cell mediated cytotoxicity
D0001916biological_processpositive regulation of T cell mediated cytotoxicity
D0002237biological_processresponse to molecule of bacterial origin
D0002376biological_processimmune system process
D0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
D0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D0002502biological_processpeptide antigen assembly with MHC class I protein complex
D0002503biological_processpeptide antigen assembly with MHC class II protein complex
D0002726biological_processpositive regulation of T cell cytokine production
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005765cellular_componentlysosomal membrane
D0005783cellular_componentendoplasmic reticulum
D0005788cellular_componentendoplasmic reticulum lumen
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006826biological_processiron ion transport
D0006879biological_processintracellular iron ion homeostasis
D0006955biological_processimmune response
D0007608biological_processsensory perception of smell
D0007611biological_processlearning or memory
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0010038biological_processresponse to metal ion
D0010977biological_processnegative regulation of neuron projection development
D0012507cellular_componentER to Golgi transport vesicle membrane
D0016020cellular_componentmembrane
D0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
D0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
D0023026molecular_functionMHC class II protein complex binding
D0030670cellular_componentphagocytic vesicle membrane
D0031901cellular_componentearly endosome membrane
D0031902cellular_componentlate endosome membrane
D0031905cellular_componentearly endosome lumen
D0033077biological_processT cell differentiation in thymus
D0033572biological_processtransferrin transport
D0034756biological_processregulation of iron ion transport
D0034757biological_processnegative regulation of iron ion transport
D0035580cellular_componentspecific granule lumen
D0042026biological_processprotein refolding
D0042605molecular_functionpeptide antigen binding
D0042612cellular_componentMHC class I protein complex
D0042613cellular_componentMHC class II protein complex
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042824cellular_componentMHC class I peptide loading complex
D0045646biological_processregulation of erythrocyte differentiation
D0048260biological_processpositive regulation of receptor-mediated endocytosis
D0048261biological_processnegative regulation of receptor-mediated endocytosis
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050768biological_processnegative regulation of neurogenesis
D0050778biological_processpositive regulation of immune response
D0050870biological_processpositive regulation of T cell activation
D0051289biological_processprotein homotetramerization
D0055038cellular_componentrecycling endosome membrane
D0060586biological_processmulticellular organismal-level iron ion homeostasis
D0070062cellular_componentextracellular exosome
D0071281biological_processcellular response to iron ion
D0071283biological_processcellular response to iron(III) ion
D0071316biological_processcellular response to nicotine
D1904724cellular_componenttertiary granule lumen
D1990000biological_processamyloid fibril formation
D1990712cellular_componentHFE-transferrin receptor complex
D2000774biological_processpositive regulation of cellular senescence
D2000978biological_processnegative regulation of forebrain neuron differentiation
E0002376biological_processimmune system process
E0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
E0016020cellular_componentmembrane
E0030670cellular_componentphagocytic vesicle membrane
E0042612cellular_componentMHC class I protein complex
E0098553cellular_componentlumenal side of endoplasmic reticulum membrane
F0000139cellular_componentGolgi membrane
F0001913biological_processT cell mediated cytotoxicity
F0001916biological_processpositive regulation of T cell mediated cytotoxicity
F0002237biological_processresponse to molecule of bacterial origin
F0002376biological_processimmune system process
F0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
F0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F0002502biological_processpeptide antigen assembly with MHC class I protein complex
F0002503biological_processpeptide antigen assembly with MHC class II protein complex
F0002726biological_processpositive regulation of T cell cytokine production
F0005198molecular_functionstructural molecule activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005765cellular_componentlysosomal membrane
F0005783cellular_componentendoplasmic reticulum
F0005788cellular_componentendoplasmic reticulum lumen
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006826biological_processiron ion transport
F0006879biological_processintracellular iron ion homeostasis
F0006955biological_processimmune response
F0007608biological_processsensory perception of smell
F0007611biological_processlearning or memory
F0009897cellular_componentexternal side of plasma membrane
F0009986cellular_componentcell surface
F0010038biological_processresponse to metal ion
F0010977biological_processnegative regulation of neuron projection development
F0012507cellular_componentER to Golgi transport vesicle membrane
F0016020cellular_componentmembrane
F0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
F0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
F0023026molecular_functionMHC class II protein complex binding
F0030670cellular_componentphagocytic vesicle membrane
F0031901cellular_componentearly endosome membrane
F0031902cellular_componentlate endosome membrane
F0031905cellular_componentearly endosome lumen
F0033077biological_processT cell differentiation in thymus
F0033572biological_processtransferrin transport
F0034756biological_processregulation of iron ion transport
F0034757biological_processnegative regulation of iron ion transport
F0035580cellular_componentspecific granule lumen
F0042026biological_processprotein refolding
F0042605molecular_functionpeptide antigen binding
F0042612cellular_componentMHC class I protein complex
F0042613cellular_componentMHC class II protein complex
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0042824cellular_componentMHC class I peptide loading complex
F0045646biological_processregulation of erythrocyte differentiation
F0048260biological_processpositive regulation of receptor-mediated endocytosis
F0048261biological_processnegative regulation of receptor-mediated endocytosis
F0050680biological_processnegative regulation of epithelial cell proliferation
F0050768biological_processnegative regulation of neurogenesis
F0050778biological_processpositive regulation of immune response
F0050870biological_processpositive regulation of T cell activation
F0051289biological_processprotein homotetramerization
F0055038cellular_componentrecycling endosome membrane
F0060586biological_processmulticellular organismal-level iron ion homeostasis
F0070062cellular_componentextracellular exosome
F0071281biological_processcellular response to iron ion
F0071283biological_processcellular response to iron(III) ion
F0071316biological_processcellular response to nicotine
F1904724cellular_componenttertiary granule lumen
F1990000biological_processamyloid fibril formation
F1990712cellular_componentHFE-transferrin receptor complex
F2000774biological_processpositive regulation of cellular senescence
F2000978biological_processnegative regulation of forebrain neuron differentiation
G0002376biological_processimmune system process
G0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
G0016020cellular_componentmembrane
G0030670cellular_componentphagocytic vesicle membrane
G0042612cellular_componentMHC class I protein complex
G0098553cellular_componentlumenal side of endoplasmic reticulum membrane
H0000139cellular_componentGolgi membrane
H0001913biological_processT cell mediated cytotoxicity
H0001916biological_processpositive regulation of T cell mediated cytotoxicity
H0002237biological_processresponse to molecule of bacterial origin
H0002376biological_processimmune system process
H0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
H0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H0002502biological_processpeptide antigen assembly with MHC class I protein complex
H0002503biological_processpeptide antigen assembly with MHC class II protein complex
H0002726biological_processpositive regulation of T cell cytokine production
H0005198molecular_functionstructural molecule activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005765cellular_componentlysosomal membrane
H0005783cellular_componentendoplasmic reticulum
H0005788cellular_componentendoplasmic reticulum lumen
H0005794cellular_componentGolgi apparatus
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005925cellular_componentfocal adhesion
H0006826biological_processiron ion transport
H0006879biological_processintracellular iron ion homeostasis
H0006955biological_processimmune response
H0007608biological_processsensory perception of smell
H0007611biological_processlearning or memory
H0009897cellular_componentexternal side of plasma membrane
H0009986cellular_componentcell surface
H0010038biological_processresponse to metal ion
H0010977biological_processnegative regulation of neuron projection development
H0012507cellular_componentER to Golgi transport vesicle membrane
H0016020cellular_componentmembrane
H0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
H0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
H0023026molecular_functionMHC class II protein complex binding
H0030670cellular_componentphagocytic vesicle membrane
H0031901cellular_componentearly endosome membrane
H0031902cellular_componentlate endosome membrane
H0031905cellular_componentearly endosome lumen
H0033077biological_processT cell differentiation in thymus
H0033572biological_processtransferrin transport
H0034756biological_processregulation of iron ion transport
H0034757biological_processnegative regulation of iron ion transport
H0035580cellular_componentspecific granule lumen
H0042026biological_processprotein refolding
H0042605molecular_functionpeptide antigen binding
H0042612cellular_componentMHC class I protein complex
H0042613cellular_componentMHC class II protein complex
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0042824cellular_componentMHC class I peptide loading complex
H0045646biological_processregulation of erythrocyte differentiation
H0048260biological_processpositive regulation of receptor-mediated endocytosis
H0048261biological_processnegative regulation of receptor-mediated endocytosis
H0050680biological_processnegative regulation of epithelial cell proliferation
H0050768biological_processnegative regulation of neurogenesis
H0050778biological_processpositive regulation of immune response
H0050870biological_processpositive regulation of T cell activation
H0051289biological_processprotein homotetramerization
H0055038cellular_componentrecycling endosome membrane
H0060586biological_processmulticellular organismal-level iron ion homeostasis
H0070062cellular_componentextracellular exosome
H0071281biological_processcellular response to iron ion
H0071283biological_processcellular response to iron(III) ion
H0071316biological_processcellular response to nicotine
H1904724cellular_componenttertiary granule lumen
H1990000biological_processamyloid fibril formation
H1990712cellular_componentHFE-transferrin receptor complex
H2000774biological_processpositive regulation of cellular senescence
H2000978biological_processnegative regulation of forebrain neuron differentiation
I0002376biological_processimmune system process
I0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
I0016020cellular_componentmembrane
I0030670cellular_componentphagocytic vesicle membrane
I0042612cellular_componentMHC class I protein complex
I0098553cellular_componentlumenal side of endoplasmic reticulum membrane
J0000139cellular_componentGolgi membrane
J0001913biological_processT cell mediated cytotoxicity
J0001916biological_processpositive regulation of T cell mediated cytotoxicity
J0002237biological_processresponse to molecule of bacterial origin
J0002376biological_processimmune system process
J0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
J0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
J0002502biological_processpeptide antigen assembly with MHC class I protein complex
J0002503biological_processpeptide antigen assembly with MHC class II protein complex
J0002726biological_processpositive regulation of T cell cytokine production
J0005198molecular_functionstructural molecule activity
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0005765cellular_componentlysosomal membrane
J0005783cellular_componentendoplasmic reticulum
J0005788cellular_componentendoplasmic reticulum lumen
J0005794cellular_componentGolgi apparatus
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0005925cellular_componentfocal adhesion
J0006826biological_processiron ion transport
J0006879biological_processintracellular iron ion homeostasis
J0006955biological_processimmune response
J0007608biological_processsensory perception of smell
J0007611biological_processlearning or memory
J0009897cellular_componentexternal side of plasma membrane
J0009986cellular_componentcell surface
J0010038biological_processresponse to metal ion
J0010977biological_processnegative regulation of neuron projection development
J0012507cellular_componentER to Golgi transport vesicle membrane
J0016020cellular_componentmembrane
J0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
J0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
J0023026molecular_functionMHC class II protein complex binding
J0030670cellular_componentphagocytic vesicle membrane
J0031901cellular_componentearly endosome membrane
J0031902cellular_componentlate endosome membrane
J0031905cellular_componentearly endosome lumen
J0033077biological_processT cell differentiation in thymus
J0033572biological_processtransferrin transport
J0034756biological_processregulation of iron ion transport
J0034757biological_processnegative regulation of iron ion transport
J0035580cellular_componentspecific granule lumen
J0042026biological_processprotein refolding
J0042605molecular_functionpeptide antigen binding
J0042612cellular_componentMHC class I protein complex
J0042613cellular_componentMHC class II protein complex
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0042824cellular_componentMHC class I peptide loading complex
J0045646biological_processregulation of erythrocyte differentiation
J0048260biological_processpositive regulation of receptor-mediated endocytosis
J0048261biological_processnegative regulation of receptor-mediated endocytosis
J0050680biological_processnegative regulation of epithelial cell proliferation
J0050768biological_processnegative regulation of neurogenesis
J0050778biological_processpositive regulation of immune response
J0050870biological_processpositive regulation of T cell activation
J0051289biological_processprotein homotetramerization
J0055038cellular_componentrecycling endosome membrane
J0060586biological_processmulticellular organismal-level iron ion homeostasis
J0070062cellular_componentextracellular exosome
J0071281biological_processcellular response to iron ion
J0071283biological_processcellular response to iron(III) ion
J0071316biological_processcellular response to nicotine
J1904724cellular_componenttertiary granule lumen
J1990000biological_processamyloid fibril formation
J1990712cellular_componentHFE-transferrin receptor complex
J2000774biological_processpositive regulation of cellular senescence
J2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
BTYR78-HIS84
APHE98-HIS104
ATYR256-HIS262

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsMOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
ChainResidueDetails
BGLN2
DGLN2
FGLN2
HGLN2
JGLN2

site_idSWS_FT_FI2
Number of Residues5
DetailsCARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
ChainResidueDetails
BILE1
DILE1
FILE1
HILE1
JILE1

site_idSWS_FT_FI3
Number of Residues30
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
BLYS19
DLYS58
DLYS91
DLYS94
FLYS19
FLYS41
FLYS48
FLYS58
FLYS91
FLYS94
HLYS19
BLYS41
HLYS41
HLYS48
HLYS58
HLYS91
HLYS94
JLYS19
JLYS41
JLYS48
JLYS58
JLYS91
BLYS48
JLYS94
BLYS58
BLYS91
BLYS94
DLYS19
DLYS41
DLYS48

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PDB entries from 2025-06-11

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