Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ZO9

Crystal Structure Of The Wild Type Heme Domain Of P450BM-3 with N-palmitoylmethionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE HEM A 471

Chain	Residue
A	LYS69
A	THR268
A	THR269
A	THR327
A	PHE331
A	PRO392
A	PHE393
A	GLY394
A	ARG398
A	ALA399
A	CYS400
A	LEU75
A	ILE401
A	HOH1486
A	HOH1489
A	HOH1491
A	HOH1493
A	HOH1503
A	HOH1526
A	HOH1535
A	LEU86
A	PHE87
A	TRP96
A	PHE107
A	PHE261
A	ALA264
A	GLY265

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE HEM B 471

Chain	Residue
B	LYS69
B	LEU75
B	LEU86
B	PHE87
B	TRP96
B	PHE107
B	PHE261
B	ALA264
B	GLY265
B	THR268
B	THR269
B	THR327
B	PHE331
B	PRO392
B	PHE393
B	GLY394
B	ARG398
B	ALA399
B	CYS400
B	ILE401
B	HOH1492
B	HOH1494
B	HOH1495
B	HOH1516
B	HOH1528
B	HOH1551

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE EPM A 1470

Chain	Residue
A	LEU29
A	TYR51
A	SER72
A	GLN73
A	ALA74
A	VAL78
A	ALA82
A	LEU188
A	THR260
A	PRO329
A	LEU437
A	HOH1762
A	HOH1927

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPM B 1471

Chain	Residue
B	LEU29
B	TYR51
B	SER72
B	GLN73
B	ALA74
B	ALA82
B	LEU188
B	LEU437
B	HOH1795

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES B 1490

Chain	Residue
B	ILE366
B	TRP367
B	ARG375
B	ARG378
B	ALA384
B	ILE385
B	PRO386
B	HOH1975

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MES B 1491

Chain	Residue
A	HOH1938
B	HIS285
B	HOH1570

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1472

Chain	Residue
A	LEU455
A	GLY457
A	HOH1829

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1473

Chain	Residue
A	GLU292
A	ALA295
A	ARG296
A	HOH1787
A	HOH1836
A	HOH1986
B	LYS59
B	HOH1926

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1474

Chain	Residue
B	LYS312
B	THR411
B	HOH1539
B	HOH1892
B	VAL308
B	LYS309

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1475

Chain	Residue
A	ASP34
A	ARG362
A	LYS364
A	VAL371
A	GLU372

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1476

Chain	Residue
A	HOH1635
A	HOH1720
A	HOH1742
A	HOH1743
A	HOH1879
B	LYS349
B	GLY350
B	HOH1972
B	HOH2001

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1477

Chain	Residue
B	ARG79
B	ASP84
B	GLU252
B	TYR256
B	HOH1715

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1478

Chain	Residue
A	ILE220
A	LEU238
A	ASP251
A	HOH1716
A	HOH1797

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1479

Chain	Residue
B	LYS94
B	GLU247
B	LYS282
B	HOH1718
B	HOH1782
B	HOH2021

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1480

Chain	Residue
A	LYS391
A	GLY394
A	ASN395
A	GLY396
A	GLN403
A	HOH1554
A	HOH1964
A	HOH2012

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1481

Chain	Residue
A	GLU143
A	PRO170
A	HOH1745
A	HOH1915
A	HOH1970

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1482

Chain	Residue
A	ASP121
A	ARG161

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1483

Chain	Residue
A	ASP68
A	THR91
A	HIS92
A	LYS336
A	HOH1623
A	HOH1734
A	HOH1886

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1484

Chain	Residue
A	GLN55
A	LYS59
A	HOH1610
A	HOH1753
B	GLN110

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1485

Chain	Residue
A	GLU131
A	ARG132
A	HOH1992

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGnGQRACIG

Chain	Residue	Details
A	PHE393-GLY402

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15020590","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SMJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"10051560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11695889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11695892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14653735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15020590","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15299332","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16403573","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17077084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17429965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17868686","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004886","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18298086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18619466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18721129","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19492389","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20180779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20947800","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21110374","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21875028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7578081","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8342039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9033595","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BVY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JME","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P0W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P0X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZO4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BMH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J1M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J4S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BEN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HF2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3M4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"16403573","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7578081","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
A	THR268
A	GLU267

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
B	THR268
B	GLU267

site_id	MCSA1
Number of Residues	3
Details	M-CSA 699

Chain	Residue	Details
A	THR268	electrostatic stabiliser, steric role
A	PHE393	electrostatic stabiliser, steric role
A	CYS400	electrostatic stabiliser

site_id	MCSA2
Number of Residues	3
Details	M-CSA 699

Chain	Residue	Details
B	THR268	electrostatic stabiliser, steric role
B	PHE393	electrostatic stabiliser, steric role
B	CYS400	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)