1ZMD
Crystal Structure of Human dihydrolipoamide dehydrogenase complexed to NADH
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001669 | cellular_component | acrosomal vesicle |
A | 0004148 | molecular_function | dihydrolipoyl dehydrogenase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005929 | cellular_component | cilium |
A | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
A | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
A | 0006508 | biological_process | proteolysis |
A | 0007369 | biological_process | gastrulation |
A | 0009083 | biological_process | branched-chain amino acid catabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0031514 | cellular_component | motile cilium |
A | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
A | 0042391 | biological_process | regulation of membrane potential |
A | 0043159 | cellular_component | acrosomal matrix |
A | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
A | 0045254 | cellular_component | pyruvate dehydrogenase complex |
A | 0047101 | molecular_function | branched-chain alpha-keto acid dehydrogenase activity |
A | 0048240 | biological_process | sperm capacitation |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
A | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
A | 1902493 | cellular_component | acetyltransferase complex |
B | 0001669 | cellular_component | acrosomal vesicle |
B | 0004148 | molecular_function | dihydrolipoyl dehydrogenase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0005929 | cellular_component | cilium |
B | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
B | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
B | 0006508 | biological_process | proteolysis |
B | 0007369 | biological_process | gastrulation |
B | 0009083 | biological_process | branched-chain amino acid catabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0031514 | cellular_component | motile cilium |
B | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
B | 0042391 | biological_process | regulation of membrane potential |
B | 0043159 | cellular_component | acrosomal matrix |
B | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
B | 0045254 | cellular_component | pyruvate dehydrogenase complex |
B | 0047101 | molecular_function | branched-chain alpha-keto acid dehydrogenase activity |
B | 0048240 | biological_process | sperm capacitation |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
B | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
B | 1902493 | cellular_component | acetyltransferase complex |
C | 0001669 | cellular_component | acrosomal vesicle |
C | 0004148 | molecular_function | dihydrolipoyl dehydrogenase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005739 | cellular_component | mitochondrion |
C | 0005759 | cellular_component | mitochondrial matrix |
C | 0005929 | cellular_component | cilium |
C | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
C | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
C | 0006508 | biological_process | proteolysis |
C | 0007369 | biological_process | gastrulation |
C | 0009083 | biological_process | branched-chain amino acid catabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
C | 0031410 | cellular_component | cytoplasmic vesicle |
C | 0031514 | cellular_component | motile cilium |
C | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
C | 0042391 | biological_process | regulation of membrane potential |
C | 0043159 | cellular_component | acrosomal matrix |
C | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
C | 0045254 | cellular_component | pyruvate dehydrogenase complex |
C | 0047101 | molecular_function | branched-chain alpha-keto acid dehydrogenase activity |
C | 0048240 | biological_process | sperm capacitation |
C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
C | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
C | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
C | 1902493 | cellular_component | acetyltransferase complex |
D | 0001669 | cellular_component | acrosomal vesicle |
D | 0004148 | molecular_function | dihydrolipoyl dehydrogenase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005634 | cellular_component | nucleus |
D | 0005739 | cellular_component | mitochondrion |
D | 0005759 | cellular_component | mitochondrial matrix |
D | 0005929 | cellular_component | cilium |
D | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
D | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
D | 0006508 | biological_process | proteolysis |
D | 0007369 | biological_process | gastrulation |
D | 0009083 | biological_process | branched-chain amino acid catabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
D | 0031410 | cellular_component | cytoplasmic vesicle |
D | 0031514 | cellular_component | motile cilium |
D | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
D | 0042391 | biological_process | regulation of membrane potential |
D | 0043159 | cellular_component | acrosomal matrix |
D | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
D | 0045254 | cellular_component | pyruvate dehydrogenase complex |
D | 0047101 | molecular_function | branched-chain alpha-keto acid dehydrogenase activity |
D | 0048240 | biological_process | sperm capacitation |
D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
D | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
D | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
D | 1902493 | cellular_component | acetyltransferase complex |
E | 0001669 | cellular_component | acrosomal vesicle |
E | 0004148 | molecular_function | dihydrolipoyl dehydrogenase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005634 | cellular_component | nucleus |
E | 0005739 | cellular_component | mitochondrion |
E | 0005759 | cellular_component | mitochondrial matrix |
E | 0005929 | cellular_component | cilium |
E | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
E | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
E | 0006508 | biological_process | proteolysis |
E | 0007369 | biological_process | gastrulation |
E | 0009083 | biological_process | branched-chain amino acid catabolic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
E | 0031410 | cellular_component | cytoplasmic vesicle |
E | 0031514 | cellular_component | motile cilium |
E | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
E | 0042391 | biological_process | regulation of membrane potential |
E | 0043159 | cellular_component | acrosomal matrix |
E | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
E | 0045254 | cellular_component | pyruvate dehydrogenase complex |
E | 0047101 | molecular_function | branched-chain alpha-keto acid dehydrogenase activity |
E | 0048240 | biological_process | sperm capacitation |
E | 0050660 | molecular_function | flavin adenine dinucleotide binding |
E | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
E | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
E | 1902493 | cellular_component | acetyltransferase complex |
F | 0001669 | cellular_component | acrosomal vesicle |
F | 0004148 | molecular_function | dihydrolipoyl dehydrogenase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005634 | cellular_component | nucleus |
F | 0005739 | cellular_component | mitochondrion |
F | 0005759 | cellular_component | mitochondrial matrix |
F | 0005929 | cellular_component | cilium |
F | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
F | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
F | 0006508 | biological_process | proteolysis |
F | 0007369 | biological_process | gastrulation |
F | 0009083 | biological_process | branched-chain amino acid catabolic process |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
F | 0031410 | cellular_component | cytoplasmic vesicle |
F | 0031514 | cellular_component | motile cilium |
F | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
F | 0042391 | biological_process | regulation of membrane potential |
F | 0043159 | cellular_component | acrosomal matrix |
F | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
F | 0045254 | cellular_component | pyruvate dehydrogenase complex |
F | 0047101 | molecular_function | branched-chain alpha-keto acid dehydrogenase activity |
F | 0048240 | biological_process | sperm capacitation |
F | 0050660 | molecular_function | flavin adenine dinucleotide binding |
F | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
F | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
F | 1902493 | cellular_component | acetyltransferase complex |
G | 0001669 | cellular_component | acrosomal vesicle |
G | 0004148 | molecular_function | dihydrolipoyl dehydrogenase activity |
G | 0005515 | molecular_function | protein binding |
G | 0005634 | cellular_component | nucleus |
G | 0005739 | cellular_component | mitochondrion |
G | 0005759 | cellular_component | mitochondrial matrix |
G | 0005929 | cellular_component | cilium |
G | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
G | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
G | 0006508 | biological_process | proteolysis |
G | 0007369 | biological_process | gastrulation |
G | 0009083 | biological_process | branched-chain amino acid catabolic process |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
G | 0031410 | cellular_component | cytoplasmic vesicle |
G | 0031514 | cellular_component | motile cilium |
G | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
G | 0042391 | biological_process | regulation of membrane potential |
G | 0043159 | cellular_component | acrosomal matrix |
G | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
G | 0045254 | cellular_component | pyruvate dehydrogenase complex |
G | 0047101 | molecular_function | branched-chain alpha-keto acid dehydrogenase activity |
G | 0048240 | biological_process | sperm capacitation |
G | 0050660 | molecular_function | flavin adenine dinucleotide binding |
G | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
G | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
G | 1902493 | cellular_component | acetyltransferase complex |
H | 0001669 | cellular_component | acrosomal vesicle |
H | 0004148 | molecular_function | dihydrolipoyl dehydrogenase activity |
H | 0005515 | molecular_function | protein binding |
H | 0005634 | cellular_component | nucleus |
H | 0005739 | cellular_component | mitochondrion |
H | 0005759 | cellular_component | mitochondrial matrix |
H | 0005929 | cellular_component | cilium |
H | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
H | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
H | 0006508 | biological_process | proteolysis |
H | 0007369 | biological_process | gastrulation |
H | 0009083 | biological_process | branched-chain amino acid catabolic process |
H | 0016491 | molecular_function | oxidoreductase activity |
H | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
H | 0031410 | cellular_component | cytoplasmic vesicle |
H | 0031514 | cellular_component | motile cilium |
H | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
H | 0042391 | biological_process | regulation of membrane potential |
H | 0043159 | cellular_component | acrosomal matrix |
H | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
H | 0045254 | cellular_component | pyruvate dehydrogenase complex |
H | 0047101 | molecular_function | branched-chain alpha-keto acid dehydrogenase activity |
H | 0048240 | biological_process | sperm capacitation |
H | 0050660 | molecular_function | flavin adenine dinucleotide binding |
H | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
H | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
H | 1902493 | cellular_component | acetyltransferase complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 2000 |
Chain | Residue |
A | HIS64 |
A | GLY68 |
A | THR69 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 2001 |
Chain | Residue |
A | GLU291 |
A | HOH2055 |
A | THR284 |
A | ASN286 |
A | LEU287 |
A | GLY288 |
A | LEU289 |
A | GLU290 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 2002 |
Chain | Residue |
A | ARG299 |
A | ARG301 |
A | GLY324 |
A | HOH2114 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 2003 |
Chain | Residue |
B | HIS64 |
B | GLY68 |
B | THR69 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 2004 |
Chain | Residue |
B | ASN286 |
B | LEU287 |
B | GLY288 |
B | LEU289 |
B | GLU290 |
B | HOH2100 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 2005 |
Chain | Residue |
A | LYS111 |
B | ILE379 |
B | GLU380 |
B | GLN409 |
B | HOH2036 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 2006 |
Chain | Residue |
B | ARG299 |
B | ARG301 |
B | ALA323 |
B | GLY324 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 2007 |
Chain | Residue |
C | HIS64 |
C | GLY68 |
C | THR69 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 2008 |
Chain | Residue |
C | ASN286 |
C | LEU287 |
C | GLY288 |
C | LEU289 |
C | GLU290 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 2009 |
Chain | Residue |
C | ILE379 |
C | GLU380 |
C | GLN409 |
C | HOH2044 |
D | LYS111 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 2010 |
Chain | Residue |
C | ARG299 |
C | ARG301 |
C | ALA323 |
C | GLY324 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 2011 |
Chain | Residue |
D | HIS64 |
D | GLY68 |
D | THR69 |
D | HOH2037 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 D 2012 |
Chain | Residue |
D | THR284 |
D | ASN286 |
D | LEU287 |
D | GLY288 |
D | LEU289 |
D | GLU290 |
D | GLU291 |
D | HOH2174 |
D | HOH2205 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 2013 |
Chain | Residue |
D | GLY378 |
D | ILE379 |
D | GLU380 |
D | GLN409 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 2014 |
Chain | Residue |
D | ARG299 |
D | ARG301 |
D | ALA323 |
D | GLY324 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 2015 |
Chain | Residue |
E | HIS64 |
E | GLY68 |
E | THR69 |
E | HOH2052 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 E 2016 |
Chain | Residue |
E | THR284 |
E | ASN286 |
E | LEU287 |
E | GLY288 |
E | LEU289 |
E | GLU290 |
site_id | BC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 E 2017 |
Chain | Residue |
E | GLY378 |
E | ILE379 |
E | GLU380 |
E | GLN409 |
E | HOH2057 |
E | HOH2121 |
E | HOH2122 |
F | LYS111 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 E 2018 |
Chain | Residue |
E | ARG299 |
E | ARG301 |
E | ALA323 |
E | GLY324 |
E | HOH2063 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 F 2019 |
Chain | Residue |
F | HIS64 |
F | GLY68 |
F | THR69 |
F | HOH2079 |
site_id | CC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 F 2020 |
Chain | Residue |
F | LEU287 |
F | GLY288 |
F | LEU289 |
F | GLU290 |
F | GLU291 |
F | HOH2291 |
F | HOH2304 |
F | THR284 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 F 2021 |
Chain | Residue |
F | GLY378 |
F | ILE379 |
F | GLU380 |
F | GLN409 |
site_id | CC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 F 2022 |
Chain | Residue |
F | ARG299 |
F | ARG301 |
G | LYS265 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 G 2023 |
Chain | Residue |
G | HIS64 |
G | GLY68 |
G | THR69 |
G | HOH2080 |
site_id | CC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 G 2024 |
Chain | Residue |
G | THR284 |
G | ASN286 |
G | LEU287 |
G | GLY288 |
G | LEU289 |
G | GLU290 |
G | GLU291 |
G | HOH2220 |
site_id | CC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 G 2025 |
Chain | Residue |
G | ILE379 |
G | GLU380 |
G | GLN409 |
site_id | CC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 G 2026 |
Chain | Residue |
F | LYS265 |
G | ARG299 |
site_id | DC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 H 2027 |
Chain | Residue |
H | HIS64 |
H | GLY68 |
H | THR69 |
H | HOH2069 |
H | HOH2190 |
site_id | DC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 H 2028 |
Chain | Residue |
H | ASN286 |
H | LEU287 |
H | GLY288 |
H | LEU289 |
H | GLU290 |
H | GLU291 |
H | HOH2281 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 H 2029 |
Chain | Residue |
G | LYS111 |
H | ILE379 |
H | GLU380 |
H | GLN409 |
H | HOH2071 |
site_id | DC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 H 2030 |
Chain | Residue |
H | ARG299 |
H | ARG301 |
H | ALA323 |
H | GLY324 |
site_id | DC5 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE FAD A 480 |
Chain | Residue |
A | ILE12 |
A | GLY13 |
A | SER14 |
A | GLY15 |
A | PRO16 |
A | GLY17 |
A | GLU36 |
A | LYS37 |
A | ASN38 |
A | GLY43 |
A | THR44 |
A | CYS45 |
A | GLY49 |
A | CYS50 |
A | LYS54 |
A | GLY117 |
A | TYR118 |
A | GLY119 |
A | ALA147 |
A | THR148 |
A | GLY149 |
A | SER150 |
A | SER168 |
A | ARG280 |
A | PHE283 |
A | GLY319 |
A | ASP320 |
A | MET326 |
A | LEU327 |
A | ALA328 |
A | HIS329 |
A | TYR359 |
A | NAI481 |
A | HOH2003 |
A | HOH2005 |
A | HOH2012 |
A | HOH2016 |
B | HIS452 |
site_id | DC6 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE NAI A 481 |
Chain | Residue |
A | PHE155 |
A | ILE184 |
A | GLY185 |
A | GLY187 |
A | VAL188 |
A | ILE189 |
A | GLU192 |
A | VAL207 |
A | GLU208 |
A | PHE209 |
A | LEU210 |
A | CYS277 |
A | ILE278 |
A | GLY279 |
A | ARG280 |
A | MET326 |
A | LEU327 |
A | VAL357 |
A | TYR359 |
A | FAD480 |
A | HOH2042 |
A | HOH2045 |
A | HOH2097 |
site_id | DC7 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE FAD B 480 |
Chain | Residue |
A | HIS452 |
A | PRO453 |
B | ILE12 |
B | GLY13 |
B | GLY15 |
B | PRO16 |
B | GLY17 |
B | ILE35 |
B | GLU36 |
B | LYS37 |
B | ASN38 |
B | GLY43 |
B | THR44 |
B | CYS45 |
B | VAL48 |
B | GLY49 |
B | CYS50 |
B | SER53 |
B | LYS54 |
B | GLY117 |
B | TYR118 |
B | GLY119 |
B | ALA147 |
B | THR148 |
B | GLY149 |
B | SER150 |
B | SER168 |
B | GLY319 |
B | ASP320 |
B | MET326 |
B | LEU327 |
B | ALA328 |
B | HIS329 |
B | TYR359 |
B | NAI481 |
B | HOH2021 |
B | HOH2045 |
B | HOH2123 |
site_id | DC8 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE NAI B 481 |
Chain | Residue |
B | GLY185 |
B | GLY187 |
B | VAL188 |
B | ILE189 |
B | GLU192 |
B | GLU208 |
B | PHE209 |
B | LEU210 |
B | CYS277 |
B | ILE278 |
B | GLY279 |
B | MET326 |
B | LEU327 |
B | VAL357 |
B | TYR359 |
B | FAD480 |
B | HOH2022 |
B | HOH2056 |
B | HOH2057 |
B | HOH2063 |
B | HOH2064 |
B | HOH2094 |
B | HOH2108 |
site_id | DC9 |
Number of Residues | 41 |
Details | BINDING SITE FOR RESIDUE FAD C 480 |
Chain | Residue |
C | ILE12 |
C | GLY13 |
C | GLY15 |
C | PRO16 |
C | GLY17 |
C | ILE35 |
C | GLU36 |
C | LYS37 |
C | ASN38 |
C | GLY43 |
C | THR44 |
C | CYS45 |
C | VAL48 |
C | GLY49 |
C | CYS50 |
C | SER53 |
C | LYS54 |
C | GLY117 |
C | TYR118 |
C | GLY119 |
C | ALA147 |
C | THR148 |
C | GLY149 |
C | SER150 |
C | SER168 |
C | ILE189 |
C | ARG280 |
C | PHE283 |
C | GLY319 |
C | ASP320 |
C | MET326 |
C | LEU327 |
C | ALA328 |
C | HIS329 |
C | TYR359 |
C | NAI481 |
C | HOH2020 |
C | HOH2026 |
C | HOH2054 |
D | HIS452 |
D | PRO453 |
site_id | EC1 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE NAI C 481 |
Chain | Residue |
C | GLY185 |
C | GLY187 |
C | VAL188 |
C | ILE189 |
C | GLU192 |
C | GLU208 |
C | PHE209 |
C | LEU210 |
C | CYS277 |
C | ILE278 |
C | GLY279 |
C | ARG280 |
C | MET326 |
C | VAL357 |
C | TYR359 |
C | FAD480 |
C | HOH2050 |
C | HOH2052 |
C | HOH2058 |
C | HOH2060 |
C | HOH2077 |
C | HOH2107 |
C | HOH2109 |
C | HOH2196 |
site_id | EC2 |
Number of Residues | 40 |
Details | BINDING SITE FOR RESIDUE FAD D 480 |
Chain | Residue |
C | HIS452 |
D | ILE12 |
D | GLY13 |
D | SER14 |
D | GLY15 |
D | PRO16 |
D | GLY17 |
D | GLU36 |
D | LYS37 |
D | ASN38 |
D | GLY43 |
D | THR44 |
D | CYS45 |
D | VAL48 |
D | GLY49 |
D | CYS50 |
D | SER53 |
D | LYS54 |
D | GLY117 |
D | TYR118 |
D | GLY119 |
D | ALA147 |
D | THR148 |
D | GLY149 |
D | SER150 |
D | SER168 |
D | ARG280 |
D | PHE283 |
D | GLY319 |
D | ASP320 |
D | MET326 |
D | LEU327 |
D | ALA328 |
D | HIS329 |
D | TYR359 |
D | NAI481 |
D | HOH2015 |
D | HOH2018 |
D | HOH2026 |
D | HOH2080 |
site_id | EC3 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE NAI D 481 |
Chain | Residue |
D | PHE155 |
D | GLY185 |
D | GLY187 |
D | VAL188 |
D | ILE189 |
D | GLU192 |
D | VAL207 |
D | GLU208 |
D | PHE209 |
D | LEU210 |
D | CYS277 |
D | ILE278 |
D | GLY279 |
D | MET326 |
D | VAL357 |
D | TYR359 |
D | FAD480 |
D | HOH2085 |
D | HOH2086 |
D | HOH2096 |
D | HOH2199 |
D | HOH2200 |
site_id | EC4 |
Number of Residues | 40 |
Details | BINDING SITE FOR RESIDUE FAD E 480 |
Chain | Residue |
E | ILE12 |
E | GLY13 |
E | SER14 |
E | GLY15 |
E | PRO16 |
E | GLY17 |
E | GLU36 |
E | LYS37 |
E | ASN38 |
E | GLY43 |
E | THR44 |
E | CYS45 |
E | VAL48 |
E | GLY49 |
E | CYS50 |
E | SER53 |
E | LYS54 |
E | TYR118 |
E | GLY119 |
E | ALA147 |
E | THR148 |
E | GLY149 |
E | SER150 |
E | SER168 |
E | ILE189 |
E | PHE283 |
E | GLY319 |
E | ASP320 |
E | MET326 |
E | LEU327 |
E | ALA328 |
E | HIS329 |
E | TYR359 |
E | NAI481 |
E | HOH2021 |
E | HOH2024 |
E | HOH2243 |
E | HOH2248 |
F | HIS452 |
F | PRO453 |
site_id | EC5 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAI E 481 |
Chain | Residue |
E | GLY185 |
E | GLY187 |
E | VAL188 |
E | ILE189 |
E | GLU192 |
E | GLU208 |
E | PHE209 |
E | LEU210 |
E | CYS277 |
E | ILE278 |
E | GLY279 |
E | ARG280 |
E | MET326 |
E | LEU327 |
E | VAL357 |
E | TYR359 |
E | FAD480 |
E | HOH2043 |
E | HOH2048 |
E | HOH2071 |
E | HOH2075 |
E | HOH2091 |
E | HOH2129 |
E | HOH2140 |
E | HOH2241 |
E | HOH2242 |
site_id | EC6 |
Number of Residues | 42 |
Details | BINDING SITE FOR RESIDUE FAD F 480 |
Chain | Residue |
E | HIS452 |
E | PRO453 |
F | ILE12 |
F | GLY13 |
F | SER14 |
F | GLY15 |
F | PRO16 |
F | GLY17 |
F | GLU36 |
F | LYS37 |
F | ASN38 |
F | GLY43 |
F | THR44 |
F | CYS45 |
F | VAL48 |
F | GLY49 |
F | CYS50 |
F | SER53 |
F | LYS54 |
F | GLY117 |
F | TYR118 |
F | GLY119 |
F | ALA147 |
F | THR148 |
F | GLY149 |
F | SER150 |
F | SER168 |
F | ARG280 |
F | PHE283 |
F | GLY319 |
F | ASP320 |
F | MET326 |
F | LEU327 |
F | ALA328 |
F | HIS329 |
F | ALA331 |
F | TYR359 |
F | NAI481 |
F | HOH2023 |
F | HOH2024 |
F | HOH2035 |
F | HOH2218 |
site_id | EC7 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAI F 481 |
Chain | Residue |
F | PHE155 |
F | ILE184 |
F | GLY185 |
F | GLY187 |
F | VAL188 |
F | ILE189 |
F | GLU192 |
F | GLU208 |
F | PHE209 |
F | CYS277 |
F | ILE278 |
F | GLY279 |
F | ARG280 |
F | MET326 |
F | LEU327 |
F | VAL357 |
F | TYR359 |
F | FAD480 |
F | HOH2095 |
F | HOH2098 |
F | HOH2147 |
F | HOH2170 |
F | HOH2172 |
F | HOH2194 |
F | HOH2196 |
F | HOH2307 |
G | SER262 |
site_id | EC8 |
Number of Residues | 40 |
Details | BINDING SITE FOR RESIDUE FAD G 480 |
Chain | Residue |
G | ILE12 |
G | GLY13 |
G | SER14 |
G | GLY15 |
G | PRO16 |
G | GLY17 |
G | GLU36 |
G | LYS37 |
G | ASN38 |
G | GLY43 |
G | THR44 |
G | CYS45 |
G | VAL48 |
G | GLY49 |
G | CYS50 |
G | SER53 |
G | LYS54 |
G | GLY117 |
G | TYR118 |
G | GLY119 |
G | ALA147 |
G | THR148 |
G | GLY149 |
G | SER150 |
G | SER168 |
G | ARG280 |
G | PHE283 |
G | GLY319 |
G | ASP320 |
G | MET326 |
G | LEU327 |
G | ALA328 |
G | HIS329 |
G | TYR359 |
G | NAI481 |
G | HOH2027 |
G | HOH2028 |
G | HOH2055 |
G | HOH2166 |
H | HIS452 |
site_id | EC9 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NAI G 481 |
Chain | Residue |
G | PHE155 |
G | GLY185 |
G | GLY187 |
G | VAL188 |
G | ILE189 |
G | GLU192 |
G | VAL207 |
G | GLU208 |
G | PHE209 |
G | LEU210 |
G | THR241 |
G | VAL243 |
G | CYS277 |
G | ILE278 |
G | GLY279 |
G | ARG280 |
G | MET326 |
G | LEU327 |
G | VAL357 |
G | TYR359 |
G | FAD480 |
G | HOH2089 |
G | HOH2093 |
G | HOH2162 |
G | HOH2203 |
G | HOH2336 |
G | HOH2338 |
G | HOH2341 |
site_id | FC1 |
Number of Residues | 40 |
Details | BINDING SITE FOR RESIDUE FAD H 480 |
Chain | Residue |
G | HIS452 |
G | PRO453 |
H | ILE12 |
H | GLY13 |
H | SER14 |
H | GLY15 |
H | PRO16 |
H | GLY17 |
H | GLU36 |
H | LYS37 |
H | ASN38 |
H | GLY43 |
H | THR44 |
H | CYS45 |
H | VAL48 |
H | GLY49 |
H | CYS50 |
H | SER53 |
H | LYS54 |
H | GLY117 |
H | TYR118 |
H | GLY119 |
H | ALA147 |
H | THR148 |
H | GLY149 |
H | SER150 |
H | SER168 |
H | PHE283 |
H | GLY319 |
H | ASP320 |
H | MET326 |
H | LEU327 |
H | ALA328 |
H | HIS329 |
H | TYR359 |
H | NAI481 |
H | HOH2031 |
H | HOH2036 |
H | HOH2095 |
H | HOH2207 |
site_id | FC2 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE NAI H 481 |
Chain | Residue |
H | GLY185 |
H | GLY187 |
H | VAL188 |
H | ILE189 |
H | GLU192 |
H | GLU208 |
H | PHE209 |
H | LEU210 |
H | CYS277 |
H | ILE278 |
H | GLY279 |
H | MET326 |
H | LEU327 |
H | VAL357 |
H | TYR359 |
H | FAD480 |
H | HOH2051 |
H | HOH2067 |
H | HOH2086 |
H | HOH2096 |
H | HOH2110 |
H | HOH2127 |
H | HOH2166 |
Functional Information from PROSITE/UniProt
site_id | PS00076 |
Number of Residues | 11 |
Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCLnvGCIP |
Chain | Residue | Details |
A | GLY42-PRO52 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P09624 |
Chain | Residue | Details |
A | HIS452 | |
B | HIS452 | |
C | HIS452 | |
D | HIS452 | |
E | HIS452 | |
F | HIS452 | |
G | HIS452 | |
H | HIS452 |
site_id | SWS_FT_FI2 |
Number of Residues | 80 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15946682 |
Chain | Residue | Details |
A | GLU36 | |
A | MET326 | |
B | GLU36 | |
B | LYS54 | |
B | GLY119 | |
B | THR148 | |
B | GLY185 | |
B | GLU208 | |
B | VAL243 | |
B | GLY279 | |
B | ASP320 | |
A | LYS54 | |
B | MET326 | |
C | GLU36 | |
C | LYS54 | |
C | GLY119 | |
C | THR148 | |
C | GLY185 | |
C | GLU208 | |
C | VAL243 | |
C | GLY279 | |
C | ASP320 | |
A | GLY119 | |
C | MET326 | |
D | GLU36 | |
D | LYS54 | |
D | GLY119 | |
D | THR148 | |
D | GLY185 | |
D | GLU208 | |
D | VAL243 | |
D | GLY279 | |
D | ASP320 | |
A | THR148 | |
D | MET326 | |
E | GLU36 | |
E | LYS54 | |
E | GLY119 | |
E | THR148 | |
E | GLY185 | |
E | GLU208 | |
E | VAL243 | |
E | GLY279 | |
E | ASP320 | |
A | GLY185 | |
E | MET326 | |
F | GLU36 | |
F | LYS54 | |
F | GLY119 | |
F | THR148 | |
F | GLY185 | |
F | GLU208 | |
F | VAL243 | |
F | GLY279 | |
F | ASP320 | |
A | GLU208 | |
F | MET326 | |
G | GLU36 | |
G | LYS54 | |
G | GLY119 | |
G | THR148 | |
G | GLY185 | |
G | GLU208 | |
G | VAL243 | |
G | GLY279 | |
G | ASP320 | |
A | VAL243 | |
G | MET326 | |
H | GLU36 | |
H | LYS54 | |
H | GLY119 | |
H | THR148 | |
H | GLY185 | |
H | GLU208 | |
H | VAL243 | |
H | GLY279 | |
H | ASP320 | |
A | GLY279 | |
H | MET326 | |
A | ASP320 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | SITE: Important for interaction with PDHX and activity of multienzyme pyruvate dehydrogenase complex => ECO:0000269|PubMed:20385101 |
Chain | Residue | Details |
A | ASP413 | |
E | TYR438 | |
F | ASP413 | |
F | TYR438 | |
G | ASP413 | |
G | TYR438 | |
H | ASP413 | |
H | TYR438 | |
A | TYR438 | |
B | ASP413 | |
B | TYR438 | |
C | ASP413 | |
C | TYR438 | |
D | ASP413 | |
D | TYR438 | |
E | ASP413 |
site_id | SWS_FT_FI4 |
Number of Residues | 56 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:O08749 |
Chain | Residue | Details |
A | LYS31 | |
B | LYS87 | |
B | LYS97 | |
B | LYS108 | |
B | LYS375 | |
B | LYS470 | |
C | LYS31 | |
C | THR69 | |
C | LYS87 | |
C | LYS97 | |
C | LYS108 | |
A | THR69 | |
C | LYS375 | |
C | LYS470 | |
D | LYS31 | |
D | THR69 | |
D | LYS87 | |
D | LYS97 | |
D | LYS108 | |
D | LYS375 | |
D | LYS470 | |
E | LYS31 | |
A | LYS87 | |
E | THR69 | |
E | LYS87 | |
E | LYS97 | |
E | LYS108 | |
E | LYS375 | |
E | LYS470 | |
F | LYS31 | |
F | THR69 | |
F | LYS87 | |
F | LYS97 | |
A | LYS97 | |
F | LYS108 | |
F | LYS375 | |
F | LYS470 | |
G | LYS31 | |
G | THR69 | |
G | LYS87 | |
G | LYS97 | |
G | LYS108 | |
G | LYS375 | |
G | LYS470 | |
A | LYS108 | |
H | LYS31 | |
H | THR69 | |
H | LYS87 | |
H | LYS97 | |
H | LYS108 | |
H | LYS375 | |
H | LYS470 | |
A | LYS375 | |
A | LYS470 | |
B | LYS31 | |
B | THR69 |
site_id | SWS_FT_FI5 |
Number of Residues | 40 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:O08749 |
Chain | Residue | Details |
A | LYS124 | |
B | LYS395 | |
C | LYS124 | |
C | LYS131 | |
C | LYS238 | |
C | LYS242 | |
C | LYS395 | |
D | LYS124 | |
D | LYS131 | |
D | LYS238 | |
D | LYS242 | |
A | LYS131 | |
D | LYS395 | |
E | LYS124 | |
E | LYS131 | |
E | LYS238 | |
E | LYS242 | |
E | LYS395 | |
F | LYS124 | |
F | LYS131 | |
F | LYS238 | |
F | LYS242 | |
A | LYS238 | |
F | LYS395 | |
G | LYS124 | |
G | LYS131 | |
G | LYS238 | |
G | LYS242 | |
G | LYS395 | |
H | LYS124 | |
H | LYS131 | |
H | LYS238 | |
H | LYS242 | |
A | LYS242 | |
H | LYS395 | |
A | LYS395 | |
B | LYS124 | |
B | LYS131 | |
B | LYS238 | |
B | LYS242 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08749 |
Chain | Residue | Details |
A | SER250 | |
B | SER250 | |
C | SER250 | |
D | SER250 | |
E | SER250 | |
F | SER250 | |
G | SER250 | |
H | SER250 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6P6R2 |
Chain | Residue | Details |
A | SER262 | |
B | SER262 | |
C | SER262 | |
D | SER262 | |
E | SER262 | |
F | SER262 | |
G | SER262 | |
H | SER262 |
site_id | SWS_FT_FI8 |
Number of Residues | 16 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O08749 |
Chain | Residue | Details |
A | LYS311 | |
E | LYS385 | |
F | LYS311 | |
F | LYS385 | |
G | LYS311 | |
G | LYS385 | |
H | LYS311 | |
H | LYS385 | |
A | LYS385 | |
B | LYS311 | |
B | LYS385 | |
C | LYS311 | |
C | LYS385 | |
D | LYS311 | |
D | LYS385 | |
E | LYS311 |
site_id | SWS_FT_FI9 |
Number of Residues | 8 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS382 | |
B | LYS382 | |
C | LYS382 | |
D | LYS382 | |
E | LYS382 | |
F | LYS382 | |
G | LYS382 | |
H | LYS382 |
site_id | SWS_FT_FI10 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER467 | |
B | SER467 | |
C | SER467 | |
D | SER467 | |
E | SER467 | |
F | SER467 | |
G | SER467 | |
H | SER467 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
A | HIS452 | |
A | GLU457 |
site_id | CSA10 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
B | CYS45 | |
B | CYS50 |
site_id | CSA11 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
C | CYS45 | |
C | CYS50 |
site_id | CSA12 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
D | CYS45 | |
D | CYS50 |
site_id | CSA13 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
E | CYS45 | |
E | CYS50 |
site_id | CSA14 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
F | CYS45 | |
F | CYS50 |
site_id | CSA15 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
G | CYS45 | |
G | CYS50 |
site_id | CSA16 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
H | CYS45 | |
H | CYS50 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
B | HIS452 | |
B | GLU457 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
C | HIS452 | |
C | GLU457 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
D | HIS452 | |
D | GLU457 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
E | HIS452 | |
E | GLU457 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
F | HIS452 | |
F | GLU457 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
G | HIS452 | |
G | GLU457 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
H | HIS452 | |
H | GLU457 |
site_id | CSA9 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
A | CYS45 | |
A | CYS50 |