1ZM9
Structure of eEF2-ETA in complex with PJ34
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019843 | molecular_function | rRNA binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043022 | molecular_function | ribosome binding |
| A | 0045901 | biological_process | positive regulation of translational elongation |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 1990145 | biological_process | maintenance of translational fidelity |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
| B | 0047286 | molecular_function | NAD+-diphthamide ADP-ribosyltransferase activity |
| C | 0003746 | molecular_function | translation elongation factor activity |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006414 | biological_process | translational elongation |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019843 | molecular_function | rRNA binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043022 | molecular_function | ribosome binding |
| C | 0045901 | biological_process | positive regulation of translational elongation |
| C | 0051087 | molecular_function | protein-folding chaperone binding |
| C | 1990145 | biological_process | maintenance of translational fidelity |
| C | 1990904 | cellular_component | ribonucleoprotein complex |
| D | 0047286 | molecular_function | NAD+-diphthamide ADP-ribosyltransferase activity |
| E | 0003746 | molecular_function | translation elongation factor activity |
| E | 0003924 | molecular_function | GTPase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005525 | molecular_function | GTP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006412 | biological_process | translation |
| E | 0006414 | biological_process | translational elongation |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0019843 | molecular_function | rRNA binding |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043022 | molecular_function | ribosome binding |
| E | 0045901 | biological_process | positive regulation of translational elongation |
| E | 0051087 | molecular_function | protein-folding chaperone binding |
| E | 1990145 | biological_process | maintenance of translational fidelity |
| E | 1990904 | cellular_component | ribonucleoprotein complex |
| F | 0047286 | molecular_function | NAD+-diphthamide ADP-ribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE P34 B 700 |
| Chain | Residue |
| B | HIS440 |
| B | GLY441 |
| B | TYR470 |
| B | ILE471 |
| B | ALA478 |
| B | TYR481 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE P34 D 701 |
| Chain | Residue |
| D | ALA478 |
| D | TYR481 |
| D | HIS440 |
| D | GLY441 |
| D | TYR470 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE P34 F 702 |
| Chain | Residue |
| F | HIS440 |
| F | GLY441 |
| F | TYR470 |
| F | ILE471 |
| F | ALA478 |
| F | TYR481 |
| F | GLU553 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DTrkdEQeRGITIksT |
| Chain | Residue | Details |
| A | ASP58-THR73 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:2885323 |
| Chain | Residue | Details |
| B | GLU553 | |
| D | GLU553 | |
| F | GLU553 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18583986 |
| Chain | Residue | Details |
| B | HIS440 | |
| F | SER449 | |
| F | GLY454 | |
| F | GLU553 | |
| B | SER449 | |
| B | GLY454 | |
| B | GLU553 | |
| D | HIS440 | |
| D | SER449 | |
| D | GLY454 | |
| D | GLU553 | |
| F | HIS440 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-methyllysine; by EFM3; alternate => ECO:0000269|PubMed:24517342, ECO:0000269|PubMed:25086354 |
| Chain | Residue | Details |
| A | LYS509 | |
| C | LYS509 | |
| E | LYS509 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER579 | |
| C | SER579 | |
| E | SER579 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-methyllysine; by EFM2; alternate => ECO:0000269|PubMed:24517342, ECO:0000269|PubMed:25086354 |
| Chain | Residue | Details |
| A | LYS613 | |
| C | LYS613 | |
| E | LYS613 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: Diphthamide => ECO:0000269|PubMed:15316019, ECO:0000269|PubMed:16950777, ECO:0000269|PubMed:721806 |
| Chain | Residue | Details |
| A | DDE699 | |
| C | DDE699 | |
| E | DDE699 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | THR713 | |
| A | THR763 | |
| C | THR713 | |
| C | THR763 | |
| E | THR713 | |
| E | THR763 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS841 | |
| C | LYS841 | |
| E | LYS841 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | ASP29 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| C | ASP29 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| E | ASP29 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLU553 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| D | GLU553 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| F | GLU553 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | HIS108 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| C | HIS108 |
| site_id | CSA9 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| E | HIS108 |
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 769 |
| Chain | Residue | Details |
| B | GLU553 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 769 |
| Chain | Residue | Details |
| D | GLU553 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 1 |
| Details | M-CSA 769 |
| Chain | Residue | Details |
| F | GLU553 | electrostatic stabiliser |
