1ZIS
Recombinant Lumazine synthase (hexagonal form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0009231 | biological_process | riboflavin biosynthetic process |
| A | 0009349 | cellular_component | riboflavin synthase complex |
| A | 0016740 | molecular_function | transferase activity |
| B | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009231 | biological_process | riboflavin biosynthetic process |
| B | 0009349 | cellular_component | riboflavin synthase complex |
| B | 0016740 | molecular_function | transferase activity |
| C | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0009231 | biological_process | riboflavin biosynthetic process |
| C | 0009349 | cellular_component | riboflavin synthase complex |
| C | 0016740 | molecular_function | transferase activity |
| D | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009231 | biological_process | riboflavin biosynthetic process |
| D | 0009349 | cellular_component | riboflavin synthase complex |
| D | 0016740 | molecular_function | transferase activity |
| E | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0009231 | biological_process | riboflavin biosynthetic process |
| E | 0009349 | cellular_component | riboflavin synthase complex |
| E | 0016740 | molecular_function | transferase activity |
| F | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0009231 | biological_process | riboflavin biosynthetic process |
| F | 0009349 | cellular_component | riboflavin synthase complex |
| F | 0016740 | molecular_function | transferase activity |
| G | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0009231 | biological_process | riboflavin biosynthetic process |
| G | 0009349 | cellular_component | riboflavin synthase complex |
| G | 0016740 | molecular_function | transferase activity |
| H | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| H | 0005829 | cellular_component | cytosol |
| H | 0009231 | biological_process | riboflavin biosynthetic process |
| H | 0009349 | cellular_component | riboflavin synthase complex |
| H | 0016740 | molecular_function | transferase activity |
| I | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| I | 0005829 | cellular_component | cytosol |
| I | 0009231 | biological_process | riboflavin biosynthetic process |
| I | 0009349 | cellular_component | riboflavin synthase complex |
| I | 0016740 | molecular_function | transferase activity |
| J | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| J | 0005829 | cellular_component | cytosol |
| J | 0009231 | biological_process | riboflavin biosynthetic process |
| J | 0009349 | cellular_component | riboflavin synthase complex |
| J | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 501 |
| Chain | Residue |
| A | GLY84 |
| A | ALA85 |
| A | THR86 |
| E | ARG127 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 502 |
| Chain | Residue |
| A | ARG127 |
| B | GLY84 |
| B | ALA85 |
| B | THR86 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 C 503 |
| Chain | Residue |
| C | GLY84 |
| C | ALA85 |
| C | THR86 |
| B | ARG127 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 D 504 |
| Chain | Residue |
| C | ARG127 |
| D | GLY84 |
| D | ALA85 |
| D | THR86 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 D 505 |
| Chain | Residue |
| D | ARG127 |
| E | GLY84 |
| E | ALA85 |
| E | THR86 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 G 506 |
| Chain | Residue |
| F | ARG127 |
| G | GLY84 |
| G | ALA85 |
| G | THR86 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 I 507 |
| Chain | Residue |
| H | ARG127 |
| I | GLY84 |
| I | ALA85 |
| I | THR86 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 H 508 |
| Chain | Residue |
| G | ARG127 |
| H | GLY84 |
| H | ALA85 |
| H | THR86 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 J 509 |
| Chain | Residue |
| I | ARG127 |
| J | GLY84 |
| J | ALA85 |
| J | THR86 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 F 510 |
| Chain | Residue |
| F | GLY84 |
| F | ALA85 |
| F | THR86 |
| J | ARG127 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE INI A 200 |
| Chain | Residue |
| A | PHE22 |
| A | ASN23 |
| A | GLY55 |
| A | ALA56 |
| A | PHE57 |
| A | GLU58 |
| A | THR80 |
| A | VAL81 |
| A | ILE82 |
| A | HIS88 |
| A | VAL92 |
| E | ILE112 |
| E | PHE113 |
| E | LYS135 |
| site_id | BC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE INI B 201 |
| Chain | Residue |
| A | ILE112 |
| A | PHE113 |
| A | LYS135 |
| B | PHE22 |
| B | ASN23 |
| B | GLY55 |
| B | ALA56 |
| B | PHE57 |
| B | GLU58 |
| B | THR80 |
| B | VAL81 |
| B | ILE82 |
| B | HIS88 |
| B | VAL92 |
| site_id | BC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE INI C 202 |
| Chain | Residue |
| B | ILE112 |
| B | PHE113 |
| C | PHE22 |
| C | ASN23 |
| C | GLY55 |
| C | ALA56 |
| C | PHE57 |
| C | GLU58 |
| C | THR80 |
| C | VAL81 |
| C | ILE82 |
| C | HIS88 |
| C | VAL92 |
| site_id | BC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE INI D 203 |
| Chain | Residue |
| C | ILE112 |
| C | PHE113 |
| C | LYS135 |
| D | PHE22 |
| D | ASN23 |
| D | GLY55 |
| D | ALA56 |
| D | PHE57 |
| D | GLU58 |
| D | THR80 |
| D | VAL81 |
| D | ILE82 |
| D | HIS88 |
| D | VAL92 |
| site_id | BC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE INI E 204 |
| Chain | Residue |
| E | ASN23 |
| E | GLY55 |
| E | ALA56 |
| E | PHE57 |
| E | GLU58 |
| E | THR80 |
| E | VAL81 |
| E | ILE82 |
| E | HIS88 |
| E | VAL92 |
| D | ILE112 |
| D | PHE113 |
| D | LYS135 |
| E | PHE22 |
| site_id | BC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE INI F 205 |
| Chain | Residue |
| F | PHE22 |
| F | ASN23 |
| F | GLY55 |
| F | ALA56 |
| F | PHE57 |
| F | GLU58 |
| F | THR80 |
| F | VAL81 |
| F | ILE82 |
| F | HIS88 |
| F | VAL92 |
| J | ILE112 |
| J | PHE113 |
| J | LYS135 |
| site_id | BC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE INI G 206 |
| Chain | Residue |
| F | ILE112 |
| F | PHE113 |
| G | PHE22 |
| G | ASN23 |
| G | GLY55 |
| G | ALA56 |
| G | PHE57 |
| G | GLU58 |
| G | THR80 |
| G | VAL81 |
| G | ILE82 |
| G | HIS88 |
| G | VAL92 |
| site_id | BC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE INI H 207 |
| Chain | Residue |
| G | ILE112 |
| G | PHE113 |
| G | LYS135 |
| H | PHE22 |
| H | ASN23 |
| H | GLY55 |
| H | ALA56 |
| H | PHE57 |
| H | GLU58 |
| H | THR80 |
| H | VAL81 |
| H | ILE82 |
| H | HIS88 |
| H | VAL92 |
| site_id | CC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE INI I 208 |
| Chain | Residue |
| H | ILE112 |
| H | PHE113 |
| I | PHE22 |
| I | ASN23 |
| I | GLY55 |
| I | ALA56 |
| I | PHE57 |
| I | GLU58 |
| I | THR80 |
| I | VAL81 |
| I | ILE82 |
| I | HIS88 |
| I | VAL92 |
| site_id | CC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE INI J 209 |
| Chain | Residue |
| I | ILE112 |
| I | PHE113 |
| J | PHE22 |
| J | ASN23 |
| J | GLY55 |
| J | ALA56 |
| J | PHE57 |
| J | GLU58 |
| J | THR80 |
| J | VAL81 |
| J | ILE82 |
| J | HIS88 |
| J | VAL92 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | ACT_SITE: Proton donor => ECO:0000255 |
| Chain | Residue | Details |
| A | HIS88 | |
| J | HIS88 | |
| B | HIS88 | |
| C | HIS88 | |
| D | HIS88 | |
| E | HIS88 | |
| F | HIS88 | |
| G | HIS88 | |
| H | HIS88 | |
| I | HIS88 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | PHE22 | |
| C | ALA56 | |
| C | THR80 | |
| C | PHE113 | |
| D | PHE22 | |
| D | ALA56 | |
| D | THR80 | |
| D | PHE113 | |
| E | PHE22 | |
| E | ALA56 | |
| E | THR80 | |
| A | ALA56 | |
| E | PHE113 | |
| F | PHE22 | |
| F | ALA56 | |
| F | THR80 | |
| F | PHE113 | |
| G | PHE22 | |
| G | ALA56 | |
| G | THR80 | |
| G | PHE113 | |
| H | PHE22 | |
| A | THR80 | |
| H | ALA56 | |
| H | THR80 | |
| H | PHE113 | |
| I | PHE22 | |
| I | ALA56 | |
| I | THR80 | |
| I | PHE113 | |
| J | PHE22 | |
| J | ALA56 | |
| J | THR80 | |
| A | PHE113 | |
| J | PHE113 | |
| B | PHE22 | |
| B | ALA56 | |
| B | THR80 | |
| B | PHE113 | |
| C | PHE22 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | ALA85 | |
| E | ARG127 | |
| F | ALA85 | |
| F | ARG127 | |
| G | ALA85 | |
| G | ARG127 | |
| H | ALA85 | |
| H | ARG127 | |
| I | ALA85 | |
| I | ARG127 | |
| J | ALA85 | |
| A | ARG127 | |
| J | ARG127 | |
| B | ALA85 | |
| B | ARG127 | |
| C | ALA85 | |
| C | ARG127 | |
| D | ALA85 | |
| D | ARG127 | |
| E | ALA85 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| A | HIS88 |
| site_id | CSA10 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| J | HIS88 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| B | HIS88 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| C | HIS88 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| D | HIS88 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| E | HIS88 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| F | HIS88 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| G | HIS88 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| H | HIS88 |
| site_id | CSA9 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| I | HIS88 |
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| A | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA10 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| J | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| B | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA3 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| C | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA4 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| D | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA5 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| E | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA6 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| F | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA7 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| G | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA8 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| H | HIS88 | proton shuttle (general acid/base) |
| site_id | MCSA9 |
| Number of Residues | 1 |
| Details | M-CSA 909 |
| Chain | Residue | Details |
| I | HIS88 | proton shuttle (general acid/base) |
