1ZET

X-ray data do not support hoogsteen base-pairing during replication by human polymerase iota

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 461

Chain	Residue
A	ASP34
A	LEU35
A	ASP126
A	TTP451

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE TTP A 451

Chain	Residue
A	TYR39
A	THR65
A	TYR68
A	ARG71
A	LYS77
A	ASP126
A	LYS214
A	MG461
A	HOH510
A	HOH550
A	HOH607
P	DOC13
T	DA5
A	ASP34
A	LEU35
A	ASP36
A	CYS37
A	PHE38

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216

Chain	Residue	Details
A	GLU127

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5

Chain	Residue	Details
A	ASP34
A	LEU35
A	ASP126

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N

Chain	Residue	Details
A	TYR39
A	ARG71

---