1ZE1
Conformational Change of Pseudouridine 55 Synthase upon Its Association with RNA Substrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001522 | biological_process | pseudouridine synthesis |
| A | 0003723 | molecular_function | RNA binding |
| A | 0006396 | biological_process | RNA processing |
| A | 0006400 | biological_process | tRNA modification |
| A | 0008033 | biological_process | tRNA processing |
| A | 0009451 | biological_process | RNA modification |
| A | 0009982 | molecular_function | pseudouridine synthase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0031119 | biological_process | tRNA pseudouridine synthesis |
| A | 0140098 | molecular_function | catalytic activity, acting on RNA |
| A | 0160148 | molecular_function | tRNA pseudouridine(55) synthase activity |
| A | 1990481 | biological_process | mRNA pseudouridine synthesis |
| B | 0001522 | biological_process | pseudouridine synthesis |
| B | 0003723 | molecular_function | RNA binding |
| B | 0006396 | biological_process | RNA processing |
| B | 0006400 | biological_process | tRNA modification |
| B | 0008033 | biological_process | tRNA processing |
| B | 0009451 | biological_process | RNA modification |
| B | 0009982 | molecular_function | pseudouridine synthase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0031119 | biological_process | tRNA pseudouridine synthesis |
| B | 0140098 | molecular_function | catalytic activity, acting on RNA |
| B | 0160148 | molecular_function | tRNA pseudouridine(55) synthase activity |
| B | 1990481 | biological_process | mRNA pseudouridine synthesis |
| C | 0001522 | biological_process | pseudouridine synthesis |
| C | 0003723 | molecular_function | RNA binding |
| C | 0006396 | biological_process | RNA processing |
| C | 0006400 | biological_process | tRNA modification |
| C | 0008033 | biological_process | tRNA processing |
| C | 0009451 | biological_process | RNA modification |
| C | 0009982 | molecular_function | pseudouridine synthase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0031119 | biological_process | tRNA pseudouridine synthesis |
| C | 0140098 | molecular_function | catalytic activity, acting on RNA |
| C | 0160148 | molecular_function | tRNA pseudouridine(55) synthase activity |
| C | 1990481 | biological_process | mRNA pseudouridine synthesis |
| D | 0001522 | biological_process | pseudouridine synthesis |
| D | 0003723 | molecular_function | RNA binding |
| D | 0006396 | biological_process | RNA processing |
| D | 0006400 | biological_process | tRNA modification |
| D | 0008033 | biological_process | tRNA processing |
| D | 0009451 | biological_process | RNA modification |
| D | 0009982 | molecular_function | pseudouridine synthase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0031119 | biological_process | tRNA pseudouridine synthesis |
| D | 0140098 | molecular_function | catalytic activity, acting on RNA |
| D | 0160148 | molecular_function | tRNA pseudouridine(55) synthase activity |
| D | 1990481 | biological_process | mRNA pseudouridine synthesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 310 |
| Chain | Residue |
| A | HIS17 |
| A | HIS34 |
| A | HOH328 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 310 |
| Chain | Residue |
| B | HIS17 |
| B | HIS34 |
| B | HOH316 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG C 310 |
| Chain | Residue |
| C | HIS17 |
| C | HIS34 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG D 310 |
| Chain | Residue |
| D | HIS34 |
| D | HIS17 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 308 |
| Details | Domain: {"description":"PUA","evidences":[{"source":"HAMAP-Rule","id":"MF_01080","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01080","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 16300397, 11976723 |
| Chain | Residue | Details |
| A | ASP39 | |
| A | TYR67 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 16300397, 11976723 |
| Chain | Residue | Details |
| B | ASP39 | |
| B | TYR67 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 16300397, 11976723 |
| Chain | Residue | Details |
| C | ASP39 | |
| C | TYR67 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 16300397, 11976723 |
| Chain | Residue | Details |
| D | ASP39 | |
| D | TYR67 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 56 |
| Chain | Residue | Details |
| A | ASP39 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | TYR67 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, van der waals interaction |
| A | ASP81 | activator, increase acidity, increase basicity, increase electrophilicity |
| A | ARG172 | activator, increase acidity, increase basicity, increase electrophilicity |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 56 |
| Chain | Residue | Details |
| B | ASP39 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | TYR67 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, van der waals interaction |
| B | ASP81 | activator, increase acidity, increase basicity, increase electrophilicity |
| B | ARG172 | activator, increase acidity, increase basicity, increase electrophilicity |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 56 |
| Chain | Residue | Details |
| C | ASP39 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
| C | TYR67 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, van der waals interaction |
| C | ASP81 | activator, increase acidity, increase basicity, increase electrophilicity |
| C | ARG172 | activator, increase acidity, increase basicity, increase electrophilicity |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 56 |
| Chain | Residue | Details |
| D | ASP39 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
| D | TYR67 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, van der waals interaction |
| D | ASP81 | activator, increase acidity, increase basicity, increase electrophilicity |
| D | ARG172 | activator, increase acidity, increase basicity, increase electrophilicity |
