1ZE1

Conformational Change of Pseudouridine 55 Synthase upon Its Association with RNA Substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001522	biological_process	pseudouridine synthesis
A	0003723	molecular_function	RNA binding
A	0006396	biological_process	RNA processing
A	0006400	biological_process	tRNA modification
A	0008033	biological_process	tRNA processing
A	0009451	biological_process	RNA modification
A	0009982	molecular_function	pseudouridine synthase activity
A	0016853	molecular_function	isomerase activity
A	0031119	biological_process	tRNA pseudouridine synthesis
A	0140098	molecular_function	catalytic activity, acting on RNA
A	0160148	molecular_function	tRNA pseudouridine(55) synthase activity
A	1990481	biological_process	mRNA pseudouridine synthesis
B	0001522	biological_process	pseudouridine synthesis
B	0003723	molecular_function	RNA binding
B	0006396	biological_process	RNA processing
B	0006400	biological_process	tRNA modification
B	0008033	biological_process	tRNA processing
B	0009451	biological_process	RNA modification
B	0009982	molecular_function	pseudouridine synthase activity
B	0016853	molecular_function	isomerase activity
B	0031119	biological_process	tRNA pseudouridine synthesis
B	0140098	molecular_function	catalytic activity, acting on RNA
B	0160148	molecular_function	tRNA pseudouridine(55) synthase activity
B	1990481	biological_process	mRNA pseudouridine synthesis
C	0001522	biological_process	pseudouridine synthesis
C	0003723	molecular_function	RNA binding
C	0006396	biological_process	RNA processing
C	0006400	biological_process	tRNA modification
C	0008033	biological_process	tRNA processing
C	0009451	biological_process	RNA modification
C	0009982	molecular_function	pseudouridine synthase activity
C	0016853	molecular_function	isomerase activity
C	0031119	biological_process	tRNA pseudouridine synthesis
C	0140098	molecular_function	catalytic activity, acting on RNA
C	0160148	molecular_function	tRNA pseudouridine(55) synthase activity
C	1990481	biological_process	mRNA pseudouridine synthesis
D	0001522	biological_process	pseudouridine synthesis
D	0003723	molecular_function	RNA binding
D	0006396	biological_process	RNA processing
D	0006400	biological_process	tRNA modification
D	0008033	biological_process	tRNA processing
D	0009451	biological_process	RNA modification
D	0009982	molecular_function	pseudouridine synthase activity
D	0016853	molecular_function	isomerase activity
D	0031119	biological_process	tRNA pseudouridine synthesis
D	0140098	molecular_function	catalytic activity, acting on RNA
D	0160148	molecular_function	tRNA pseudouridine(55) synthase activity
D	1990481	biological_process	mRNA pseudouridine synthesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 310

Chain	Residue
A	HIS17
A	HIS34
A	HOH328

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 310

Chain	Residue
B	HIS17
B	HIS34
B	HOH316

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 310

Chain	Residue
C	HIS17
C	HIS34

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 310

Chain	Residue
D	HIS34
D	HIS17

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01080

Chain	Residue	Details
A	ASP39
B	ASP39
C	ASP39
D	ASP39

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 16300397, 11976723

Chain	Residue	Details
A	ASP39
A	TYR67

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site_id	CSA2
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 16300397, 11976723

Chain	Residue	Details
B	ASP39
B	TYR67

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site_id	CSA3
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 16300397, 11976723

Chain	Residue	Details
C	ASP39
C	TYR67

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site_id	CSA4
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 16300397, 11976723

Chain	Residue	Details
D	ASP39
D	TYR67

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 56

Chain	Residue	Details
A	ASP39	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
A	TYR67	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, van der waals interaction
A	ASP81	activator, increase acidity, increase basicity, increase electrophilicity
A	ARG172	activator, increase acidity, increase basicity, increase electrophilicity

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 56

Chain	Residue	Details
B	ASP39	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
B	TYR67	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, van der waals interaction
B	ASP81	activator, increase acidity, increase basicity, increase electrophilicity
B	ARG172	activator, increase acidity, increase basicity, increase electrophilicity

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site_id	MCSA3
Number of Residues	4
Details	M-CSA 56

Chain	Residue	Details
C	ASP39	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
C	TYR67	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, van der waals interaction
C	ASP81	activator, increase acidity, increase basicity, increase electrophilicity
C	ARG172	activator, increase acidity, increase basicity, increase electrophilicity

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site_id	MCSA4
Number of Residues	4
Details	M-CSA 56

Chain	Residue	Details
D	ASP39	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
D	TYR67	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, van der waals interaction
D	ASP81	activator, increase acidity, increase basicity, increase electrophilicity
D	ARG172	activator, increase acidity, increase basicity, increase electrophilicity

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