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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1ZCD

Crystal structure of the Na+/H+ antiporter NhaA

Functional Information from GO Data
ChainGOidnamespacecontents
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006814biological_processsodium ion transport
A0006885biological_processregulation of pH
A0009651biological_processresponse to salt stress
A0010446biological_processresponse to alkaline pH
A0015081molecular_functionsodium ion transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0015385molecular_functionsodium:proton antiporter activity
A0016020cellular_componentmembrane
A0035725biological_processsodium ion transmembrane transport
A0051453biological_processregulation of intracellular pH
A0055085biological_processtransmembrane transport
A1901612molecular_functioncardiolipin binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006814biological_processsodium ion transport
B0006885biological_processregulation of pH
B0009651biological_processresponse to salt stress
B0010446biological_processresponse to alkaline pH
B0015081molecular_functionsodium ion transmembrane transporter activity
B0015297molecular_functionantiporter activity
B0015385molecular_functionsodium:proton antiporter activity
B0016020cellular_componentmembrane
B0035725biological_processsodium ion transmembrane transport
B0051453biological_processregulation of intracellular pH
B0055085biological_processtransmembrane transport
B1901612molecular_functioncardiolipin binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues38
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues108
DetailsTopological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues170
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues38
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues14
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues38
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues34
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues36
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues26
DetailsRegion: {"description":"Important for dimerization","evidences":[{"source":"PubMed","id":"17635927","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23836890","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsSite: {"description":"Important for stability, cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29410365","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsSite: {"description":"Essential for cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19274728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30409911","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsSite: {"description":"Essential for cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19274728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsSite: {"description":"Important for pH response","evidences":[{"source":"PubMed","id":"10455127","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsSite: {"description":"Important for pH response","evidences":[{"source":"PubMed","id":"14604993","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsSite: {"description":"Important for stability and activity","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28330875","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30409911","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2025-10-15

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