1ZCD
Crystal structure of the Na+/H+ antiporter NhaA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006885 | biological_process | regulation of pH |
| A | 0009651 | biological_process | response to salt stress |
| A | 0010446 | biological_process | response to alkaline pH |
| A | 0015081 | molecular_function | sodium ion transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015385 | molecular_function | sodium:proton antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1901612 | molecular_function | cardiolipin binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0006885 | biological_process | regulation of pH |
| B | 0009651 | biological_process | response to salt stress |
| B | 0010446 | biological_process | response to alkaline pH |
| B | 0015081 | molecular_function | sodium ion transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015385 | molecular_function | sodium:proton antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0051453 | biological_process | regulation of intracellular pH |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1901612 | molecular_function | cardiolipin binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 190 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | MET1-ASP11 | |
| B | GLY201-ARG204 | |
| B | ILE237-HIS253 | |
| B | ALA311-PHE339 | |
| A | ARG81-PHE96 | |
| A | ALA131-ILE154 | |
| A | GLY201-ARG204 | |
| A | ILE237-HIS253 | |
| A | ALA311-PHE339 | |
| B | MET1-ASP11 | |
| B | ARG81-PHE96 | |
| B | ALA131-ILE154 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | ALA12-SER31 | |
| B | ALA12-SER31 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 108 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | GLY32-ASN58 | |
| B | GLY223 | |
| B | GLY273-SER286 | |
| B | GLY351-LEU357 | |
| A | TYR117-THR122 | |
| A | ASN177-SER180 | |
| A | GLY223 | |
| A | GLY273-SER286 | |
| A | GLY351-LEU357 | |
| B | GLY32-ASN58 | |
| B | TYR117-THR122 | |
| B | ASN177-SER180 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | MET59-LYS80 | |
| B | MET59-LYS80 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | PRO97-ASN116 | |
| B | PRO97-ASN116 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | ARG123-ALA130 | |
| B | ARG123-ALA130 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | PHE155-THR176 | |
| B | PHE155-THR176 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | MET181-CYS200 | |
| B | MET181-CYS200 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | THR205-SER222 | |
| B | THR205-SER222 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | VAL224-PHE236 | |
| B | VAL224-PHE236 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | VAL254-ALA272 | |
| B | VAL254-ALA272 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | ILE287-LEU310 | |
| B | ILE287-LEU310 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | THR340-PHE350 | |
| B | THR340-PHE350 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | ILE358-LEU380 | |
| B | ILE358-LEU380 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 14 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 |
| Chain | Residue | Details |
| A | ARG381-VAL388 | |
| B | ARG381-VAL388 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | SITE: Important for stability, cation binding and translocation => ECO:0000305|PubMed:15988517, ECO:0000305|PubMed:22915592, ECO:0000305|PubMed:27021484, ECO:0000305|PubMed:29410365, ECO:0000305|PubMed:7737413 |
| Chain | Residue | Details |
| A | ASP133 | |
| B | ASP133 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | SITE: Essential for cation binding and translocation => ECO:0000305|PubMed:15988517, ECO:0000305|PubMed:19274728, ECO:0000305|PubMed:22915592, ECO:0000305|PubMed:25422503, ECO:0000305|PubMed:27021484, ECO:0000305|PubMed:27708266, ECO:0000305|PubMed:30409911, ECO:0000305|PubMed:7737413 |
| Chain | Residue | Details |
| A | ASP163 | |
| B | ASP163 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | SITE: Essential for cation binding and translocation => ECO:0000305|PubMed:15988517, ECO:0000305|PubMed:19274728, ECO:0000305|PubMed:22915592, ECO:0000305|PubMed:25422503, ECO:0000305|PubMed:27021484, ECO:0000305|PubMed:27708266, ECO:0000305|PubMed:7737413 |
| Chain | Residue | Details |
| A | ASP164 | |
| B | ASP164 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 4 |
| Details | SITE: Important for pH response => ECO:0000305|PubMed:10455127 |
| Chain | Residue | Details |
| A | GLU241 | |
| A | VAL254 | |
| B | GLU241 | |
| B | VAL254 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | SITE: Important for pH response => ECO:0000305|PubMed:14604993 |
| Chain | Residue | Details |
| A | GLU252 | |
| B | GLU252 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | SITE: Important for stability and activity => ECO:0000305|PubMed:15988517, ECO:0000305|PubMed:22915592, ECO:0000305|PubMed:25422503, ECO:0000305|PubMed:27708266, ECO:0000305|PubMed:28330875, ECO:0000305|PubMed:30409911 |
| Chain | Residue | Details |
| A | LYS300 | |
| B | LYS300 |
