1ZCA
Crystal structure of G alpha 12 in complex with GDP, Mg2+ and AlF4-
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001664 | molecular_function | G protein-coupled receptor binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007266 | biological_process | Rho protein signal transduction |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| B | 0001664 | molecular_function | G protein-coupled receptor binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007266 | biological_process | Rho protein signal transduction |
| B | 0019001 | molecular_function | guanyl nucleotide binding |
| B | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 383 |
| Chain | Residue |
| A | SER69 |
| A | THR206 |
| A | GDP382 |
| A | ALF384 |
| A | HOH386 |
| A | HOH387 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ALF A 384 |
| Chain | Residue |
| A | ARG203 |
| A | ALA205 |
| A | THR206 |
| A | VAL226 |
| A | GLY228 |
| A | GLN229 |
| A | GDP382 |
| A | MG383 |
| A | HOH385 |
| A | HOH386 |
| A | HOH387 |
| A | GLY64 |
| A | GLU65 |
| A | LYS68 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1383 |
| Chain | Residue |
| B | SER69 |
| B | THR206 |
| B | GDP1382 |
| B | ALF1384 |
| B | HOH1386 |
| B | HOH1387 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ALF B 1384 |
| Chain | Residue |
| B | GLY64 |
| B | GLU65 |
| B | LYS68 |
| B | ARG203 |
| B | ALA205 |
| B | THR206 |
| B | VAL226 |
| B | GLY227 |
| B | GLY228 |
| B | GLN229 |
| B | GDP1382 |
| B | MG1383 |
| B | HOH1385 |
| B | HOH1386 |
| B | HOH1387 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP A 382 |
| Chain | Residue |
| A | GLU65 |
| A | SER66 |
| A | GLY67 |
| A | LYS68 |
| A | SER69 |
| A | THR70 |
| A | SER176 |
| A | LEU200 |
| A | LEU201 |
| A | ALA202 |
| A | ARG203 |
| A | ASN294 |
| A | LYS295 |
| A | ASP297 |
| A | LEU298 |
| A | THR350 |
| A | ALA351 |
| A | ILE352 |
| A | MG383 |
| A | ALF384 |
| A | HOH386 |
| A | HOH387 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GDP B 1382 |
| Chain | Residue |
| B | GLU65 |
| B | SER66 |
| B | GLY67 |
| B | LYS68 |
| B | SER69 |
| B | THR70 |
| B | SER176 |
| B | LEU200 |
| B | LEU201 |
| B | ARG203 |
| B | ASN294 |
| B | LYS295 |
| B | ASP297 |
| B | LEU298 |
| B | THR350 |
| B | ALA351 |
| B | ILE352 |
| B | MG1383 |
| B | ALF1384 |
| B | HOH1386 |
| B | HOH1387 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16388592, ECO:0007744|PDB:1ZCA |
| Chain | Residue | Details |
| A | SER66 | |
| A | LEU201 | |
| A | LYS295 | |
| A | ILE352 | |
| B | SER66 | |
| B | LEU201 | |
| B | LYS295 | |
| B | ILE352 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16388592 |
| Chain | Residue | Details |
| A | THR70 | |
| A | LYS207 | |
| B | THR70 | |
| B | LYS207 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q14344 |
| Chain | Residue | Details |
| A | LYS207 | |
| B | LYS207 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:9485474 |
| Chain | Residue | Details |
| A | ALA31 | |
| B | ALA31 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN229 | |
| A | THR206 | |
| A | GLU65 | |
| A | ARG203 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLN229 | |
| B | THR206 | |
| B | GLU65 | |
| B | ARG203 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN229 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLN229 |
