Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1Z6Z

Crystal Structure of Human Sepiapterin Reductase in complex with NADP+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004757	molecular_function	sepiapterin reductase (NADP+) activity
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0006809	biological_process	nitric oxide biosynthetic process
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0050661	molecular_function	NADP binding
A	0070062	cellular_component	extracellular exosome
B	0004757	molecular_function	sepiapterin reductase (NADP+) activity
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0006809	biological_process	nitric oxide biosynthetic process
B	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0050661	molecular_function	NADP binding
B	0070062	cellular_component	extracellular exosome
C	0004757	molecular_function	sepiapterin reductase (NADP+) activity
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0006809	biological_process	nitric oxide biosynthetic process
C	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
C	0016491	molecular_function	oxidoreductase activity
C	0050661	molecular_function	NADP binding
C	0070062	cellular_component	extracellular exosome
D	0004757	molecular_function	sepiapterin reductase (NADP+) activity
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0006809	biological_process	nitric oxide biosynthetic process
D	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
D	0016491	molecular_function	oxidoreductase activity
D	0050661	molecular_function	NADP binding
D	0070062	cellular_component	extracellular exosome
E	0004757	molecular_function	sepiapterin reductase (NADP+) activity
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0006809	biological_process	nitric oxide biosynthetic process
E	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
E	0016491	molecular_function	oxidoreductase activity
E	0050661	molecular_function	NADP binding
E	0070062	cellular_component	extracellular exosome
F	0004757	molecular_function	sepiapterin reductase (NADP+) activity
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0006809	biological_process	nitric oxide biosynthetic process
F	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
F	0016491	molecular_function	oxidoreductase activity
F	0050661	molecular_function	NADP binding
F	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	LYS87
A	GLY88
A	LEU89
C	ARG45

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 401

Chain	Residue
A	ARG39

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 402

Chain	Residue
C	ARG39

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 403

Chain	Residue
D	ARG39

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 405

Chain	Residue
C	GLY88

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 406

Chain	Residue
C	TYR167
C	NAP803
B	TYR-4

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 407

Chain	Residue
A	SER154
A	TYR167
A	NAP801

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 408

Chain	Residue
B	SER154
B	TYR167
B	NAP802

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 409

Chain	Residue
D	SER154
D	TYR167
D	NAP804

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 410

Chain	Residue
E	SER154
E	TYR167
E	NAP805

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL F 411

Chain	Residue
F	SER154
F	TYR167
F	NAP806

site_id	BC3
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAP A 801

Chain	Residue
A	GLY11
A	SER13
A	ARG14
A	GLY15
A	PHE16
A	ALA38
A	ARG39
A	ASN40
A	ALA65
A	ASP66
A	LEU67
A	ASN97
A	LEU123
A	ILE152
A	SER153
A	TYR167
A	LYS171
A	PRO195
A	GLY196
A	PRO197
A	LEU198
A	THR200
A	MET202
A	GLN203
A	CL407
A	HOH802
A	HOH808
A	HOH831
A	HOH843
A	HOH851
A	HOH856

site_id	BC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAP B 802

Chain	Residue
B	GLY11
B	SER13
B	ARG14
B	GLY15
B	PHE16
B	ARG39
B	ASN40
B	ALA65
B	ASP66
B	LEU67
B	ASN97
B	ALA98
B	LEU123
B	ILE152
B	SER153
B	TYR167
B	LYS171
B	PRO195
B	GLY196
B	PRO197
B	LEU198
B	THR200
B	MET202
B	GLN203
B	CL408
B	HOH826
B	HOH829

site_id	BC5
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAP C 803

Chain	Residue
C	TYR167
C	LYS171
C	PRO195
C	GLY196
C	PRO197
C	LEU198
C	THR200
C	MET202
C	GLN203
C	CL406
C	HOH808
C	HOH836
C	HOH837
C	HOH857
C	HOH863
C	GLY11
C	SER13
C	ARG14
C	GLY15
C	PHE16
C	ARG39
C	ASN40
C	ALA65
C	ASP66
C	LEU67
C	ASN97
C	ALA98
C	LEU123
C	ILE152
C	SER153

site_id	BC6
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAP D 804

Chain	Residue
D	GLY11
D	SER13
D	ARG14
D	GLY15
D	PHE16
D	ALA38
D	ARG39
D	ASN40
D	ALA65
D	ASP66
D	LEU67
D	ASN97
D	ALA98
D	LEU123
D	ILE152
D	SER153
D	TYR167
D	LYS171
D	PRO195
D	GLY196
D	PRO197
D	LEU198
D	THR200
D	MET202
D	GLN203
D	CL409
D	HOH808
D	HOH811
D	HOH817
D	HOH837

site_id	BC7
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAP E 805

Chain	Residue
E	GLY11
E	SER13
E	ARG14
E	GLY15
E	PHE16
E	ARG39
E	ASN40
E	ALA65
E	ASP66
E	LEU67
E	ASN97
E	LEU123
E	ILE152
E	SER153
E	TYR167
E	LYS171
E	PRO195
E	GLY196
E	PRO197
E	LEU198
E	THR200
E	MET202
E	GLN203
E	CL410

site_id	BC8
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAP F 806

Chain	Residue
F	GLY11
F	SER13
F	ARG14
F	GLY15
F	PHE16
F	ARG39
F	ASN40
F	ALA65
F	ASP66
F	LEU67
F	ASN97
F	LEU123
F	ILE152
F	SER153
F	TYR167
F	LYS171
F	PRO195
F	GLY196
F	PRO197
F	LEU198
F	THR200
F	MET202
F	GLN203
F	CL411
F	HOH815

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human sepiapterin reductase.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	30
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P18297","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by CaMK2; in vitro","evidences":[{"source":"PubMed","id":"11825621","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
A	SER154
A	TYR167
A	ASN124
A	LYS171

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
D	TRP164
D	LYS171

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
E	TRP164
E	LYS171

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
F	TRP164
F	LYS171

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
A	TYR167
A	LYS171

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
B	TYR167
B	LYS171

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
C	TYR167
C	LYS171

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
D	TYR167
D	LYS171

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
E	TYR167
E	LYS171

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
F	TYR167
F	LYS171

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
B	SER154
B	TYR167
B	ASN124
B	LYS171

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
C	SER154
C	TYR167
C	ASN124
C	LYS171

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
D	SER154
D	TYR167
D	ASN124
D	LYS171

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
E	SER154
E	TYR167
E	ASN124
E	LYS171

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
F	SER154
F	TYR167
F	ASN124
F	LYS171

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
A	TRP164
A	LYS171

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
B	TRP164
B	LYS171

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1ybv

Chain	Residue	Details
C	TRP164
C	LYS171

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)