1Z69

Crystal structure of methylenetetrahydromethanopterin reductase (Mer) in complex with coenzyme F420

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006730	biological_process	one-carbon metabolic process
A	0015948	biological_process	methanogenesis
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0018537	molecular_function	coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
A	0019386	biological_process	methanogenesis, from carbon dioxide
B	0005737	cellular_component	cytoplasm
B	0006730	biological_process	one-carbon metabolic process
B	0015948	biological_process	methanogenesis
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0018537	molecular_function	coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
B	0019386	biological_process	methanogenesis, from carbon dioxide
C	0005737	cellular_component	cytoplasm
C	0006730	biological_process	one-carbon metabolic process
C	0015948	biological_process	methanogenesis
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0018537	molecular_function	coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
C	0019386	biological_process	methanogenesis, from carbon dioxide
D	0005737	cellular_component	cytoplasm
D	0006730	biological_process	one-carbon metabolic process
D	0015948	biological_process	methanogenesis
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0018537	molecular_function	coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
D	0019386	biological_process	methanogenesis, from carbon dioxide

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL B 4001

Chain	Residue
B	ALA50
B	LEU51
B	THR53
B	ASN54
C	ALA50
C	LEU51
C	THR53

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CL D 4002

Chain	Residue
A	THR53
A	ASN54
D	ALA50
D	LEU51
D	THR53
D	ASN54
A	ALA50
A	LEU51

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE F42 A 328

Chain	Residue
A	THR34
A	ASP35
A	HIS36
A	GLY61
A	VAL62
A	PRO94
A	GLY95
A	ASP96
A	TRP107
A	LYS109
A	PRO110
A	LEU111
A	ALA112
A	GLY156
A	ALA157
A	GLN158
A	GLY159
A	PRO160
A	LYS161
A	MET162
A	LEU174
A	ASN176
A	HOH4047
A	HOH4118

---

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE F42 B 1328

Chain	Residue
B	THR34
B	ASP35
B	HIS36
B	GLY61
B	VAL62
B	GLY95
B	ASP96
B	TRP107
B	LYS109
B	LEU111
B	ALA157
B	GLN158
B	GLY159
B	PRO160
B	LYS161
B	MET162
B	LEU174
B	ASN176
B	TYR209
B	HOH4054

---

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE F42 C 2328

Chain	Residue
C	THR34
C	ASP35
C	HIS36
C	GLY61
C	VAL62
C	PRO94
C	GLY95
C	ASP96
C	LYS109
C	PRO110
C	LEU111
C	ALA112
C	ALA157
C	GLN158
C	GLY159
C	PRO160
C	LYS161
C	MET162
C	LEU174
C	ASN176
C	TYR209
C	HOH4043

---

site_id	AC6
Number of Residues	26
Details	BINDING SITE FOR RESIDUE F42 D 3328

Chain	Residue
D	LYS161
D	MET162
D	LEU174
D	ASN176
D	TYR209
D	HOH4108
D	HOH4204
D	HOH4515
D	THR34
D	ASP35
D	HIS36
D	GLY61
D	VAL62
D	PRO94
D	GLY95
D	ASP96
D	TRP107
D	LYS109
D	PRO110
D	LEU111
D	ALA112
D	GLY156
D	ALA157
D	GLN158
D	GLY159
D	PRO160

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PG D 4003

Chain	Residue
C	ALA145
D	VAL8
D	SER10
D	HIS36
D	ASN38
D	ASN39
D	SER307

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