1Z69
Crystal structure of methylenetetrahydromethanopterin reductase (Mer) in complex with coenzyme F420
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0018537 | molecular_function | coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity |
| A | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0018537 | molecular_function | coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity |
| B | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0018537 | molecular_function | coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity |
| C | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0018537 | molecular_function | coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity |
| D | 0019386 | biological_process | methanogenesis, from carbon dioxide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL B 4001 |
| Chain | Residue |
| B | ALA50 |
| B | LEU51 |
| B | THR53 |
| B | ASN54 |
| C | ALA50 |
| C | LEU51 |
| C | THR53 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CL D 4002 |
| Chain | Residue |
| A | THR53 |
| A | ASN54 |
| D | ALA50 |
| D | LEU51 |
| D | THR53 |
| D | ASN54 |
| A | ALA50 |
| A | LEU51 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE F42 A 328 |
| Chain | Residue |
| A | THR34 |
| A | ASP35 |
| A | HIS36 |
| A | GLY61 |
| A | VAL62 |
| A | PRO94 |
| A | GLY95 |
| A | ASP96 |
| A | TRP107 |
| A | LYS109 |
| A | PRO110 |
| A | LEU111 |
| A | ALA112 |
| A | GLY156 |
| A | ALA157 |
| A | GLN158 |
| A | GLY159 |
| A | PRO160 |
| A | LYS161 |
| A | MET162 |
| A | LEU174 |
| A | ASN176 |
| A | HOH4047 |
| A | HOH4118 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE F42 B 1328 |
| Chain | Residue |
| B | THR34 |
| B | ASP35 |
| B | HIS36 |
| B | GLY61 |
| B | VAL62 |
| B | GLY95 |
| B | ASP96 |
| B | TRP107 |
| B | LYS109 |
| B | LEU111 |
| B | ALA157 |
| B | GLN158 |
| B | GLY159 |
| B | PRO160 |
| B | LYS161 |
| B | MET162 |
| B | LEU174 |
| B | ASN176 |
| B | TYR209 |
| B | HOH4054 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE F42 C 2328 |
| Chain | Residue |
| C | THR34 |
| C | ASP35 |
| C | HIS36 |
| C | GLY61 |
| C | VAL62 |
| C | PRO94 |
| C | GLY95 |
| C | ASP96 |
| C | LYS109 |
| C | PRO110 |
| C | LEU111 |
| C | ALA112 |
| C | ALA157 |
| C | GLN158 |
| C | GLY159 |
| C | PRO160 |
| C | LYS161 |
| C | MET162 |
| C | LEU174 |
| C | ASN176 |
| C | TYR209 |
| C | HOH4043 |
| site_id | AC6 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE F42 D 3328 |
| Chain | Residue |
| D | LYS161 |
| D | MET162 |
| D | LEU174 |
| D | ASN176 |
| D | TYR209 |
| D | HOH4108 |
| D | HOH4204 |
| D | HOH4515 |
| D | THR34 |
| D | ASP35 |
| D | HIS36 |
| D | GLY61 |
| D | VAL62 |
| D | PRO94 |
| D | GLY95 |
| D | ASP96 |
| D | TRP107 |
| D | LYS109 |
| D | PRO110 |
| D | LEU111 |
| D | ALA112 |
| D | GLY156 |
| D | ALA157 |
| D | GLN158 |
| D | GLY159 |
| D | PRO160 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PG D 4003 |
| Chain | Residue |
| C | ALA145 |
| D | VAL8 |
| D | SER10 |
| D | HIS36 |
| D | ASN38 |
| D | ASN39 |
| D | SER307 |
