1Z5A
Topoisomerase VI-B, ADP-bound dimer form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1001 |
| Chain | Residue |
| A | ASN42 |
| A | ADP2001 |
| A | HOH2060 |
| A | HOH2087 |
| A | HOH2088 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | HOH2119 |
| B | ASN42 |
| B | LYS98 |
| B | ADP2002 |
| B | HOH2056 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ADP A 2001 |
| Chain | Residue |
| A | ASN42 |
| A | ALA46 |
| A | ASP76 |
| A | ILE81 |
| A | ALA89 |
| A | SER96 |
| A | SER97 |
| A | LYS98 |
| A | GLY106 |
| A | MET107 |
| A | TYR108 |
| A | GLY109 |
| A | VAL112 |
| A | LYS113 |
| A | MG1001 |
| A | HOH2003 |
| A | HOH2004 |
| A | HOH2007 |
| A | HOH2011 |
| A | HOH2024 |
| A | HOH2087 |
| A | HOH2088 |
| B | PHE7 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ADP B 2002 |
| Chain | Residue |
| A | PHE7 |
| B | ASN42 |
| B | ALA46 |
| B | ASP76 |
| B | GLY80 |
| B | ILE81 |
| B | ALA89 |
| B | TYR95 |
| B | SER96 |
| B | SER97 |
| B | LYS98 |
| B | GLY106 |
| B | MET107 |
| B | TYR108 |
| B | GLY109 |
| B | VAL112 |
| B | LYS113 |
| B | THR170 |
| B | MG1002 |
| B | HOH2008 |
| B | HOH2025 |
| B | HOH2055 |
| B | HOH2056 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12505993, ECO:0000269|PubMed:15939019, ECO:0007744|PDB:1MX0, ECO:0007744|PDB:1Z59, ECO:0007744|PDB:1Z5A, ECO:0007744|PDB:1Z5B, ECO:0007744|PDB:1Z5C |
| Chain | Residue | Details |
| A | ASN42 | |
| A | ASP76 | |
| A | MET107 | |
| B | ASN42 | |
| B | ASP76 | |
| B | MET107 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12505993, ECO:0000269|PubMed:15939019, ECO:0007744|PDB:1MX0, ECO:0007744|PDB:1Z5A, ECO:0007744|PDB:1Z5B, ECO:0007744|PDB:1Z5C |
| Chain | Residue | Details |
| A | SER96 | |
| B | SER96 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12505993, ECO:0007744|PDB:1MX0 |
| Chain | Residue | Details |
| A | LYS427 | |
| B | LYS427 |
