1Z4M

Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with uridine 5'-monophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008253	molecular_function	5'-nucleotidase activity
A	0009264	biological_process	deoxyribonucleotide catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2001

Chain	Residue
A	ASN41
A	ASP43
A	ASP176
A	U5P1001
A	HOH3050
A	HOH3051

---

site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE U5P A 1001

Chain	Residue
A	PHE49
A	PHE75
A	TRP76
A	VAL77
A	SER78
A	TRP96
A	PHE102
A	THR130
A	SER131
A	PRO132
A	ILE133
A	LYS143
A	LYS165
A	MG2001
A	GOL3001
A	HOH3025
A	HOH3050
A	HOH3051
A	HOH3054
A	HOH3150
A	HOH3151
A	HOH3152
A	HOH3153
A	HOH3161
A	ASN41
A	MET42
A	ASP43

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 3001

Chain	Residue
A	TRP96
A	GLU97
A	ILE133
A	LYS134
A	MET135
A	U5P1001
A	HOH3154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15044615","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q91","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15044615","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q91","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12352955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12352955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1q91

Chain	Residue	Details
A	ASP43
A	ASN41

---

site_id	MCSA1
Number of Residues	3
Details	M-CSA 812

Chain	Residue	Details
A	ASN41	covalently attached, metal ligand, nucleofuge, nucleophile
A	ASP43	metal ligand
A	ASP176	metal ligand

---