1Z4J

Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with uridine 2'-monophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008253	molecular_function	5'-nucleotidase activity
A	0009264	biological_process	deoxyribonucleotide catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1001

Chain	Residue
A	ASN41
A	ASP43
A	ASP176
A	U2P3001
A	HOH4004
A	HOH4008

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2001

Chain	Residue
A	HOH4146
A	HOH4147
A	HOH4149
A	ALA119
A	LEU121
A	THR124

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site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE U2P A 3001

Chain	Residue
A	ASN41
A	ASP43
A	PHE49
A	TRP76
A	VAL77
A	THR130
A	SER131
A	PRO132
A	LYS143
A	LYS165
A	MG1001
A	HOH4004
A	HOH4008
A	HOH4011
A	HOH4037
A	HOH4039
A	HOH4070
A	HOH4144

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 4001

Chain	Residue
A	GLU97
A	MET135
A	HIS212
A	HOH4030
A	HOH4093

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12352955","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1q91

Chain	Residue	Details
A	ASP43
A	ASN41

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site_id	MCSA1
Number of Residues	3
Details	M-CSA 812

Chain	Residue	Details
A	ASN41	covalently attached, metal ligand, nucleofuge, nucleophile
A	ASP43	metal ligand
A	ASP176	metal ligand

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