1Z2O
Inositol 1,3,4-trisphosphate 5/6-Kinase in complex with mg2+/ADP/Ins(1,3,4,6)P4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0000287 | molecular_function | magnesium ion binding |
| X | 0005524 | molecular_function | ATP binding |
| X | 0016301 | molecular_function | kinase activity |
| X | 0016310 | biological_process | phosphorylation |
| X | 0016853 | molecular_function | isomerase activity |
| X | 0032957 | biological_process | inositol trisphosphate metabolic process |
| X | 0046872 | molecular_function | metal ion binding |
| X | 0047325 | molecular_function | inositol tetrakisphosphate 1-kinase activity |
| X | 0052725 | molecular_function | inositol-1,3,4-trisphosphate 6-kinase activity |
| X | 0052726 | molecular_function | inositol-1,3,4-trisphosphate 5-kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG X 1295 |
| Chain | Residue |
| X | ASP275 |
| X | ASP289 |
| X | ADP871 |
| X | I4P2699 |
| X | HOH2700 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG X 1296 |
| Chain | Residue |
| X | HOH2703 |
| X | ASP289 |
| X | ASN291 |
| X | ADP871 |
| X | HOH2702 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE ADP X 871 |
| Chain | Residue |
| X | ARG94 |
| X | PRO109 |
| X | LYS136 |
| X | HIS147 |
| X | MET149 |
| X | GLN168 |
| X | HIS169 |
| X | TYR170 |
| X | ILE171 |
| X | HIS173 |
| X | ILE177 |
| X | SER194 |
| X | LEU195 |
| X | ASN210 |
| X | ASP275 |
| X | VAL288 |
| X | ASP289 |
| X | MG1295 |
| X | MG1296 |
| X | I4P2699 |
| X | HOH2700 |
| X | HOH2702 |
| X | HOH2703 |
| X | HOH2714 |
| X | HOH2770 |
| X | HOH2919 |
| X | HOH3186 |
| X | HOH3205 |
| site_id | AC4 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE I4P X 2699 |
| Chain | Residue |
| X | LYS17 |
| X | THR20 |
| X | LYS57 |
| X | GLN141 |
| X | GLY142 |
| X | HIS147 |
| X | LYS179 |
| X | PHE181 |
| X | ASP275 |
| X | ASP289 |
| X | ASN291 |
| X | PRO294 |
| X | SER295 |
| X | TYR296 |
| X | ADP871 |
| X | MG1295 |
| X | HOH2700 |
| X | HOH2702 |
| X | HOH2715 |
| X | HOH2781 |
| X | HOH2840 |
| X | HOH2856 |
| X | HOH2919 |
| X | HOH2922 |
| X | HOH2927 |
| X | HOH2930 |
| X | HOH2980 |
| X | HOH3044 |
| X | HOH3074 |
| X | HOH3119 |
| X | HOH3165 |
| X | HOH3172 |
| X | HOH3201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15837423, ECO:0007744|PDB:1Z2P |
| Chain | Residue | Details |
| X | LYS17 | |
| X | GLN141 | |
| X | GLY142 | |
| X | SER295 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15837423, ECO:0007744|PDB:1Z2O |
| Chain | Residue | Details |
| X | LYS57 | |
| X | LYS179 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:15837423, ECO:0007744|PDB:1Z2P |
| Chain | Residue | Details |
| X | ARG94 | |
| X | LYS136 | |
| X | HIS147 | |
| X | GLN168 | |
| X | HIS169 | |
| X | TYR170 | |
| X | ILE171 | |
| X | SER194 | |
| X | VAL288 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15837423, ECO:0007744|PDB:1Z2N |
| Chain | Residue | Details |
| X | ASN210 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15837423, ECO:0007744|PDB:1Z2N, ECO:0007744|PDB:1Z2O, ECO:0007744|PDB:1Z2P |
| Chain | Residue | Details |
| X | ASP275 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15837423, ECO:0007744|PDB:1Z2O, ECO:0007744|PDB:1Z2P |
| Chain | Residue | Details |
| X | ASP289 | |
| X | ASN291 |
