1Z2M

Crystal Structure of ISG15, the Interferon-Induced Ubiquitin Cross Reactive Protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007229	biological_process	integrin-mediated signaling pathway
A	0009615	biological_process	response to virus
A	0009617	biological_process	response to bacterium
A	0016567	biological_process	protein ubiquitination
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030501	biological_process	positive regulation of bone mineralization
A	0031386	molecular_function	protein tag activity
A	0031397	biological_process	negative regulation of protein ubiquitination
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032020	biological_process	ISG15-protein conjugation
A	0032461	biological_process	positive regulation of protein oligomerization
A	0032649	biological_process	regulation of type II interferon production
A	0032728	biological_process	positive regulation of interferon-beta production
A	0032729	biological_process	positive regulation of type II interferon production
A	0032733	biological_process	positive regulation of interleukin-10 production
A	0034340	biological_process	response to type I interferon
A	0042742	biological_process	defense response to bacterium
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0051607	biological_process	defense response to virus
A	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
A	0070585	biological_process	protein localization to mitochondrion

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OS4 A 400

Chain	Residue
A	MET9
A	GLY12
A	ASN13
A	HOH526

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Interacts with activating enzyme => ECO:0000250

Chain	Residue	Details
A	LEU154

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine; alternate => ECO:0000269|PubMed:18606809

Chain	Residue	Details
A	ASP79

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