1Z0K

Structure of GTP-Bound Rab4Q67L GTPase in complex with the central Rab binding domain of Rabenosyn-5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0032482	biological_process	Rab protein signal transduction
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0032482	biological_process	Rab protein signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1201

Chain	Residue
A	SER22
A	THR40
A	GTP1200
A	HOH1207
A	HOH1212

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 2201

Chain	Residue
C	HOH2222
C	SER22
C	THR40
C	GTP2200
C	HOH2208

---

site_id	AC3
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GTP A 1200

Chain	Residue
A	ALA17
A	GLY18
A	THR19
A	GLY20
A	LYS21
A	SER22
A	CYS23
A	PHE33
A	SER37
A	HIS39
A	THR40
A	ALA65
A	GLY66
A	ASN121
A	LYS122
A	ASP124
A	LEU125
A	SER151
A	ALA152
A	LEU153
A	MG1201
A	HOH1207
A	HOH1210
A	HOH1212
A	HOH1262
A	HOH1285
A	HOH1304
A	HOH1317
A	HOH1348
C	ASP35
C	HOH2300

---

site_id	AC4
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GTP C 2200

Chain	Residue
C	ALA17
C	GLY18
C	THR19
C	GLY20
C	LYS21
C	SER22
C	CYS23
C	PHE33
C	SER37
C	HIS39
C	THR40
C	GLY66
C	ASN121
C	LYS122
C	ASP124
C	LEU125
C	SER151
C	ALA152
C	LEU153
C	MG2201
C	HOH2208
C	HOH2219
C	HOH2222
C	HOH2247

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES D 1001

Chain	Residue
C	GLU30
D	GLY442
D	TRP443
D	LEU444
D	LYS474
D	MET479
D	HOH1072

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Motif: {"description":"Switch 1","evidences":[{"source":"UniProtKB","id":"P61106","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Motif: {"description":"Switch 2","evidences":[{"source":"UniProtKB","id":"P61106","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z0K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PDB","id":"1Z0K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15907487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Z0K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BME","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P61018","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"5-glutamyl serotonin","evidences":[{"source":"UniProtKB","id":"P56371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	LEU67

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	LEU67

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLY18

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLY18

---