1YXV
Crystal Structure of Kinase Pim1 in complex with 3,4-Dihydroxy-1-methylquinolin-2(1H)-one
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005730 | cellular_component | nucleolus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006338 | biological_process | chromatin remodeling |
A | 0006468 | biological_process | protein phosphorylation |
A | 0006915 | biological_process | apoptotic process |
A | 0008134 | molecular_function | transcription factor binding |
A | 0016310 | biological_process | phosphorylation |
A | 0022898 | biological_process | regulation of transmembrane transporter activity |
A | 0030145 | molecular_function | manganese ion binding |
A | 0043024 | molecular_function | ribosomal small subunit binding |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0043433 | biological_process | negative regulation of DNA-binding transcription factor activity |
A | 0044024 | molecular_function | histone H2AS1 kinase activity |
A | 0045824 | biological_process | negative regulation of innate immune response |
A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
A | 0046777 | biological_process | protein autophosphorylation |
A | 0046872 | molecular_function | metal ion binding |
A | 0050821 | biological_process | protein stabilization |
A | 0060045 | biological_process | positive regulation of cardiac muscle cell proliferation |
A | 0070561 | biological_process | vitamin D receptor signaling pathway |
A | 0071346 | biological_process | cellular response to type II interferon |
A | 0090336 | biological_process | positive regulation of brown fat cell differentiation |
A | 0106310 | molecular_function | protein serine kinase activity |
A | 1902033 | biological_process | regulation of hematopoietic stem cell proliferation |
A | 1904263 | biological_process | positive regulation of TORC1 signaling |
A | 1905062 | biological_process | positive regulation of cardioblast proliferation |
A | 1990748 | biological_process | cellular detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IMD A 322 |
Chain | Residue |
A | PHE130 |
A | THR134 |
A | ASP170 |
A | ASP234 |
A | GLY238 |
A | ASP239 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE LI6 A 323 |
Chain | Residue |
A | ALA65 |
A | ILE104 |
A | LEU120 |
A | LEU174 |
A | ILE185 |
A | ASP186 |
A | HOH340 |
A | LEU44 |
A | PHE49 |
A | VAL52 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK |
Chain | Residue | Details |
A | LEU44-LYS67 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI |
Chain | Residue | Details |
A | VAL163-ILE175 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
A | ASP167 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LEU44 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 |
Chain | Residue | Details |
A | LYS67 | |
A | GLU121 | |
A | ASP128 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:15657054 |
Chain | Residue | Details |
A | SER98 | |
A | SER261 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP167 | |
A | GLU171 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | LYS169 | |
A | ASP167 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | THR204 | |
A | LYS169 | |
A | ASP167 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASN172 | |
A | LYS169 | |
A | ASP167 |