Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1YXU

Crystal Structure of Kinase Pim1 in Complex with AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030145	molecular_function	manganese ion binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0045824	biological_process	negative regulation of innate immune response
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0050821	biological_process	protein stabilization
A	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
A	0070561	biological_process	vitamin D receptor signaling pathway
A	0071346	biological_process	cellular response to type II interferon
A	0090336	biological_process	positive regulation of brown fat cell differentiation
A	0106310	molecular_function	protein serine kinase activity
A	1902033	biological_process	regulation of hematopoietic stem cell proliferation
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1905062	biological_process	positive regulation of cardioblast proliferation
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006468	biological_process	protein phosphorylation
B	0006915	biological_process	apoptotic process
B	0007346	biological_process	regulation of mitotic cell cycle
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0030145	molecular_function	manganese ion binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0045824	biological_process	negative regulation of innate immune response
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
B	0050821	biological_process	protein stabilization
B	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
B	0070561	biological_process	vitamin D receptor signaling pathway
B	0071346	biological_process	cellular response to type II interferon
B	0090336	biological_process	positive regulation of brown fat cell differentiation
B	0106310	molecular_function	protein serine kinase activity
B	1902033	biological_process	regulation of hematopoietic stem cell proliferation
B	1904263	biological_process	positive regulation of TORC1 signaling
B	1905062	biological_process	positive regulation of cardioblast proliferation
C	0000166	molecular_function	nucleotide binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006468	biological_process	protein phosphorylation
C	0006915	biological_process	apoptotic process
C	0007346	biological_process	regulation of mitotic cell cycle
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0030145	molecular_function	manganese ion binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0045824	biological_process	negative regulation of innate immune response
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046872	molecular_function	metal ion binding
C	0050821	biological_process	protein stabilization
C	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
C	0070561	biological_process	vitamin D receptor signaling pathway
C	0071346	biological_process	cellular response to type II interferon
C	0090336	biological_process	positive regulation of brown fat cell differentiation
C	0106310	molecular_function	protein serine kinase activity
C	1902033	biological_process	regulation of hematopoietic stem cell proliferation
C	1904263	biological_process	positive regulation of TORC1 signaling
C	1905062	biological_process	positive regulation of cardioblast proliferation
D	0000166	molecular_function	nucleotide binding
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006468	biological_process	protein phosphorylation
D	0006915	biological_process	apoptotic process
D	0007346	biological_process	regulation of mitotic cell cycle
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0030145	molecular_function	manganese ion binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0045824	biological_process	negative regulation of innate immune response
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046872	molecular_function	metal ion binding
D	0050821	biological_process	protein stabilization
D	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
D	0070561	biological_process	vitamin D receptor signaling pathway
D	0071346	biological_process	cellular response to type II interferon
D	0090336	biological_process	positive regulation of brown fat cell differentiation
D	0106310	molecular_function	protein serine kinase activity
D	1902033	biological_process	regulation of hematopoietic stem cell proliferation
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1905062	biological_process	positive regulation of cardioblast proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD A 500

Chain	Residue
A	PHE130
A	THR134
A	ASP170
A	ASP234
A	GLY238
A	ASP239

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD B 600

Chain	Residue
B	ASP170
B	ASP234
B	GLY238
B	ASP239
B	PHE130
B	ILE133
B	THR134

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD C 700

Chain	Residue
C	PHE130
C	THR134
C	ASP170
C	ASP234
C	GLY238

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD D 800

Chain	Residue
D	PHE130
D	ILE133
D	THR134
D	ASP170
D	ASP234
D	GLY238
D	ASP239

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AMP A 550

Chain	Residue
A	LEU44
A	PHE49
A	ALA65
A	LYS67
A	GLU89
A	ILE104
A	LEU120
A	GLU171
A	ASN172
A	LEU174
A	ILE185
A	ASP186
A	HOH626

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP B 650

Chain	Residue
B	LEU44
B	PHE49
B	VAL52
B	ALA65
B	LYS67
B	ILE104
B	LEU120
B	VAL126
B	GLU171
B	ASN172
B	ILE185
B	ASP186

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AMP C 750

Chain	Residue
C	LEU44
C	PHE49
C	ALA65
C	LYS67
C	ILE104
C	LEU120
C	ARG122
C	VAL126
C	GLU171
C	ASN172
C	LEU174
C	ILE185
C	ASP186

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP D 850

Chain	Residue
D	PHE49
D	VAL52
D	ALA65
D	LYS67
D	GLU89
D	ILE104
D	LEU120
D	GLU121
D	ARG122
D	LEU174
D	ILE185
D	ASP186

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK

Chain	Residue	Details
A	LEU44-LYS67

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI

Chain	Residue	Details
A	VAL163-ILE175

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1008
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15525646","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15657054","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15808862","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15657054","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP167
A	GLU171

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	THR204
B	LYS169
B	ASP167

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	THR204
C	LYS169
C	ASP167

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	THR204
D	LYS169
D	ASP167

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN172
A	LYS169
A	ASP167

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASN172
B	LYS169
B	ASP167

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN172
C	LYS169
C	ASP167

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASN172
D	LYS169
D	ASP167

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP167
B	GLU171

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP167
C	GLU171

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP167
D	GLU171

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS169
A	ASP167

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	LYS169
B	ASP167

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS169
C	ASP167

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	LYS169
D	ASP167

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR204
A	LYS169
A	ASP167

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)