1YWH

crystal structure of urokinase plasminogen activator receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006935	biological_process	chemotaxis
A	0007165	biological_process	signal transduction
A	0007596	biological_process	blood coagulation
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0010755	biological_process	regulation of plasminogen activation
A	0016020	cellular_component	membrane
A	0019898	cellular_component	extrinsic component of membrane
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0030155	biological_process	regulation of cell adhesion
A	0030162	biological_process	regulation of proteolysis
A	0030377	molecular_function	urokinase plasminogen activator receptor activity
A	0031639	biological_process	plasminogen activation
A	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
A	0034394	biological_process	protein localization to cell surface
A	0035579	cellular_component	specific granule membrane
A	0038023	molecular_function	signaling receptor activity
A	0038195	biological_process	urokinase plasminogen activator signaling pathway
A	0042995	cellular_component	cell projection
A	0043066	biological_process	negative regulation of apoptotic process
A	0043388	biological_process	positive regulation of DNA binding
A	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
A	0051917	biological_process	regulation of fibrinolysis
A	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
A	0098552	cellular_component	side of membrane
A	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
A	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006935	biological_process	chemotaxis
C	0007165	biological_process	signal transduction
C	0007596	biological_process	blood coagulation
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0010755	biological_process	regulation of plasminogen activation
C	0016020	cellular_component	membrane
C	0019898	cellular_component	extrinsic component of membrane
C	0019899	molecular_function	enzyme binding
C	0019904	molecular_function	protein domain specific binding
C	0030155	biological_process	regulation of cell adhesion
C	0030162	biological_process	regulation of proteolysis
C	0030377	molecular_function	urokinase plasminogen activator receptor activity
C	0031639	biological_process	plasminogen activation
C	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
C	0034394	biological_process	protein localization to cell surface
C	0035579	cellular_component	specific granule membrane
C	0038023	molecular_function	signaling receptor activity
C	0038195	biological_process	urokinase plasminogen activator signaling pathway
C	0042995	cellular_component	cell projection
C	0043066	biological_process	negative regulation of apoptotic process
C	0043388	biological_process	positive regulation of DNA binding
C	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
C	0051917	biological_process	regulation of fibrinolysis
C	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
C	0098552	cellular_component	side of membrane
C	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
C	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0005102	molecular_function	signaling receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006935	biological_process	chemotaxis
E	0007165	biological_process	signal transduction
E	0007596	biological_process	blood coagulation
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010755	biological_process	regulation of plasminogen activation
E	0016020	cellular_component	membrane
E	0019898	cellular_component	extrinsic component of membrane
E	0019899	molecular_function	enzyme binding
E	0019904	molecular_function	protein domain specific binding
E	0030155	biological_process	regulation of cell adhesion
E	0030162	biological_process	regulation of proteolysis
E	0030377	molecular_function	urokinase plasminogen activator receptor activity
E	0031639	biological_process	plasminogen activation
E	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
E	0034394	biological_process	protein localization to cell surface
E	0035579	cellular_component	specific granule membrane
E	0038023	molecular_function	signaling receptor activity
E	0038195	biological_process	urokinase plasminogen activator signaling pathway
E	0042995	cellular_component	cell projection
E	0043066	biological_process	negative regulation of apoptotic process
E	0043388	biological_process	positive regulation of DNA binding
E	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
E	0051917	biological_process	regulation of fibrinolysis
E	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
E	0098552	cellular_component	side of membrane
E	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
E	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
G	0001934	biological_process	positive regulation of protein phosphorylation
G	0005102	molecular_function	signaling receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006935	biological_process	chemotaxis
G	0007165	biological_process	signal transduction
G	0007596	biological_process	blood coagulation
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010755	biological_process	regulation of plasminogen activation
G	0016020	cellular_component	membrane
G	0019898	cellular_component	extrinsic component of membrane
G	0019899	molecular_function	enzyme binding
G	0019904	molecular_function	protein domain specific binding
G	0030155	biological_process	regulation of cell adhesion
G	0030162	biological_process	regulation of proteolysis
G	0030377	molecular_function	urokinase plasminogen activator receptor activity
G	0031639	biological_process	plasminogen activation
G	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
G	0034394	biological_process	protein localization to cell surface
G	0035579	cellular_component	specific granule membrane
G	0038023	molecular_function	signaling receptor activity
G	0038195	biological_process	urokinase plasminogen activator signaling pathway
G	0042995	cellular_component	cell projection
G	0043066	biological_process	negative regulation of apoptotic process
G	0043388	biological_process	positive regulation of DNA binding
G	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
G	0051917	biological_process	regulation of fibrinolysis
G	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
G	0098552	cellular_component	side of membrane
G	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
G	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
I	0001934	biological_process	positive regulation of protein phosphorylation
I	0005102	molecular_function	signaling receptor binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005788	cellular_component	endoplasmic reticulum lumen
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005886	cellular_component	plasma membrane
I	0005925	cellular_component	focal adhesion
I	0006935	biological_process	chemotaxis
I	0007165	biological_process	signal transduction
I	0007596	biological_process	blood coagulation
I	0009897	cellular_component	external side of plasma membrane
I	0009986	cellular_component	cell surface
I	0010755	biological_process	regulation of plasminogen activation
I	0016020	cellular_component	membrane
I	0019898	cellular_component	extrinsic component of membrane
I	0019899	molecular_function	enzyme binding
I	0019904	molecular_function	protein domain specific binding
I	0030155	biological_process	regulation of cell adhesion
I	0030162	biological_process	regulation of proteolysis
I	0030377	molecular_function	urokinase plasminogen activator receptor activity
I	0031639	biological_process	plasminogen activation
I	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
I	0034394	biological_process	protein localization to cell surface
I	0035579	cellular_component	specific granule membrane
I	0038023	molecular_function	signaling receptor activity
I	0038195	biological_process	urokinase plasminogen activator signaling pathway
I	0042995	cellular_component	cell projection
I	0043066	biological_process	negative regulation of apoptotic process
I	0043388	biological_process	positive regulation of DNA binding
I	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
I	0051917	biological_process	regulation of fibrinolysis
I	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
I	0098552	cellular_component	side of membrane
I	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
I	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
K	0001934	biological_process	positive regulation of protein phosphorylation
K	0005102	molecular_function	signaling receptor binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005788	cellular_component	endoplasmic reticulum lumen
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005886	cellular_component	plasma membrane
K	0005925	cellular_component	focal adhesion
K	0006935	biological_process	chemotaxis
K	0007165	biological_process	signal transduction
K	0007596	biological_process	blood coagulation
K	0009897	cellular_component	external side of plasma membrane
K	0009986	cellular_component	cell surface
K	0010755	biological_process	regulation of plasminogen activation
K	0016020	cellular_component	membrane
K	0019898	cellular_component	extrinsic component of membrane
K	0019899	molecular_function	enzyme binding
K	0019904	molecular_function	protein domain specific binding
K	0030155	biological_process	regulation of cell adhesion
K	0030162	biological_process	regulation of proteolysis
K	0030377	molecular_function	urokinase plasminogen activator receptor activity
K	0031639	biological_process	plasminogen activation
K	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
K	0034394	biological_process	protein localization to cell surface
K	0035579	cellular_component	specific granule membrane
K	0038023	molecular_function	signaling receptor activity
K	0038195	biological_process	urokinase plasminogen activator signaling pathway
K	0042995	cellular_component	cell projection
K	0043066	biological_process	negative regulation of apoptotic process
K	0043388	biological_process	positive regulation of DNA binding
K	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
K	0051917	biological_process	regulation of fibrinolysis
K	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
K	0098552	cellular_component	side of membrane
K	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
K	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
M	0001934	biological_process	positive regulation of protein phosphorylation
M	0005102	molecular_function	signaling receptor binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005788	cellular_component	endoplasmic reticulum lumen
M	0005789	cellular_component	endoplasmic reticulum membrane
M	0005886	cellular_component	plasma membrane
M	0005925	cellular_component	focal adhesion
M	0006935	biological_process	chemotaxis
M	0007165	biological_process	signal transduction
M	0007596	biological_process	blood coagulation
M	0009897	cellular_component	external side of plasma membrane
M	0009986	cellular_component	cell surface
M	0010755	biological_process	regulation of plasminogen activation
M	0016020	cellular_component	membrane
M	0019898	cellular_component	extrinsic component of membrane
M	0019899	molecular_function	enzyme binding
M	0019904	molecular_function	protein domain specific binding
M	0030155	biological_process	regulation of cell adhesion
M	0030162	biological_process	regulation of proteolysis
M	0030377	molecular_function	urokinase plasminogen activator receptor activity
M	0031639	biological_process	plasminogen activation
M	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
M	0034394	biological_process	protein localization to cell surface
M	0035579	cellular_component	specific granule membrane
M	0038023	molecular_function	signaling receptor activity
M	0038195	biological_process	urokinase plasminogen activator signaling pathway
M	0042995	cellular_component	cell projection
M	0043066	biological_process	negative regulation of apoptotic process
M	0043388	biological_process	positive regulation of DNA binding
M	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
M	0051917	biological_process	regulation of fibrinolysis
M	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
M	0098552	cellular_component	side of membrane
M	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
M	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
O	0001934	biological_process	positive regulation of protein phosphorylation
O	0005102	molecular_function	signaling receptor binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005788	cellular_component	endoplasmic reticulum lumen
O	0005789	cellular_component	endoplasmic reticulum membrane
O	0005886	cellular_component	plasma membrane
O	0005925	cellular_component	focal adhesion
O	0006935	biological_process	chemotaxis
O	0007165	biological_process	signal transduction
O	0007596	biological_process	blood coagulation
O	0009897	cellular_component	external side of plasma membrane
O	0009986	cellular_component	cell surface
O	0010755	biological_process	regulation of plasminogen activation
O	0016020	cellular_component	membrane
O	0019898	cellular_component	extrinsic component of membrane
O	0019899	molecular_function	enzyme binding
O	0019904	molecular_function	protein domain specific binding
O	0030155	biological_process	regulation of cell adhesion
O	0030162	biological_process	regulation of proteolysis
O	0030377	molecular_function	urokinase plasminogen activator receptor activity
O	0031639	biological_process	plasminogen activation
O	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
O	0034394	biological_process	protein localization to cell surface
O	0035579	cellular_component	specific granule membrane
O	0038023	molecular_function	signaling receptor activity
O	0038195	biological_process	urokinase plasminogen activator signaling pathway
O	0042995	cellular_component	cell projection
O	0043066	biological_process	negative regulation of apoptotic process
O	0043388	biological_process	positive regulation of DNA binding
O	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
O	0051917	biological_process	regulation of fibrinolysis
O	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
O	0098552	cellular_component	side of membrane
O	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
O	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00983
Number of Residues	44
Details	LY6_UPAR Ly-6 / u-PAR domain signature. RCMqCktngd...Crve.....ECAlgqdlCrttivrlweegeelelveks....C

Chain	Residue	Details
A	ARG2-CYS45
A	GLU94-CYS147
A	GLN193-CYS247

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Site: {"description":"Cleavage; by U-PA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16456079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22285761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16456079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22285761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---