1YT1

Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0006457	biological_process	protein folding
A	0016887	molecular_function	ATP hydrolysis activity
A	0051082	molecular_function	unfolded protein binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0005524	molecular_function	ATP binding
B	0006457	biological_process	protein folding
B	0016887	molecular_function	ATP hydrolysis activity
B	0051082	molecular_function	unfolded protein binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 A 501

Chain	Residue
A	THR212
A	ARG237
A	THR240
A	THR248
A	HOH614
A	HOH657
A	HOH682
A	HOH702

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 A 502

Chain	Residue
A	HIS146
A	TRP282
A	HOH603
A	HOH672
A	HOH684
A	LYS137

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 A 503

Chain	Residue
A	ALA111
A	ASP149
A	MET154
A	HOH505
A	HOH595
A	HOH683

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 A 504

Chain	Residue
A	ASP110
A	LYS114
A	HOH592
A	HOH594

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PG4 B 508

Chain	Residue
B	THR212
B	ARG237
B	THR248
B	PG4509
B	HOH621
B	HOH662
B	HOH710
B	HOH804
B	HOH817

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 B 509

Chain	Residue
B	LYS137
B	THR148
B	PG4508
B	HOH667
B	HOH675
B	HOH792

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 B 511

Chain	Residue
B	ASN129
B	ASN239
B	GLY242

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PG4 B 512

Chain	Residue
B	ASP262
B	THR263
B	ASN266
B	HOH712
B	HOH797
B	HOH824
B	HOH833

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1PE B 606

Chain	Residue
A	ASN83
A	LYS87
A	ILE90
A	SER227
B	ASN83
B	LYS87
B	ILE90
B	SER227
B	HOH670

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 B 613

Chain	Residue
B	ASN107
B	ALA111
B	ASP149
B	MET154
B	HOH617

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 B 614

Chain	Residue
B	ASP110
B	LYS114
B	PG4615

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 B 615

Chain	Residue
B	LYS114
B	PG4614
B	HOH755

---

Functional Information from PROSITE/UniProt

site_id	PS00298
Number of Residues	10
Details	HSP90 Heat shock hsp90 proteins family signature. YkNKEIFLRE

Chain	Residue	Details
A	TYR94-GLU103

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:1YT0, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASN107
B	ASN107

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TBW, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:1YT0, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASP149
B	ASP149
B	PHE199
A	PHE199

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TBW, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASN162
B	ASN162

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P14625

Chain	Residue	Details
A	LYS168
B	LYS168

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q66HD0

Chain	Residue	Details
A	SER172
B	SER172

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000255

Chain	Residue	Details
A	GLY325
B	GLY325

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000250|UniProtKB:P14625, ECO:0000255

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN107
A	ASN217
B	ASN107
B	ASN217

---