1YSL
Crystal structure of HMG-CoA synthase from Enterococcus faecalis with AcetoAcetyl-CoA ligand.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | LYS7 |
| A | THR64 |
| A | ARG167 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 604 |
| Chain | Residue |
| A | HOH720 |
| B | TYR183 |
| B | PRO188 |
| A | ASP83 |
| A | THR377 |
| A | VAL378 |
| A | ARG379 |
| A | HOH650 |
| A | HOH654 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| B | LYS7 |
| B | THR64 |
| B | ARG167 |
| B | HOH707 |
| B | HOH772 |
| B | HOH818 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE COA B 601 |
| Chain | Residue |
| A | ALA254 |
| B | ASP29 |
| B | GLY31 |
| B | LYS32 |
| B | GLY36 |
| B | TYR143 |
| B | GLY148 |
| B | GLY149 |
| B | THR152 |
| B | VAL196 |
| B | SER201 |
| B | ASN202 |
| B | PRO235 |
| B | TYR236 |
| B | MET239 |
| B | LYS242 |
| B | AAE611 |
| B | HOH778 |
| B | HOH829 |
| B | HOH858 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AAE B 611 |
| Chain | Residue |
| B | CYS111 |
| B | TYR143 |
| B | PHE185 |
| B | HIS233 |
| B | ASN275 |
| B | TYR277 |
| B | SER308 |
| B | COA601 |
| B | HOH814 |
| B | HOH858 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 605 |
| Chain | Residue |
| A | TYR183 |
| A | PRO188 |
| B | ILE82 |
| B | ASP83 |
| B | THR377 |
| B | ARG379 |
| B | HOH651 |
| B | HOH855 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250 |
| Chain | Residue | Details |
| B | GLU79 | |
| B | HIS233 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000269|PubMed:16245942 |
| Chain | Residue | Details |
| B | CSD111 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | ASP29 | |
| B | SER201 | |
| B | ASN275 |
