1YS4
Structure of Aspartate-Semialdehyde Dehydrogenase from Methanococcus jannaschii
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009085 | biological_process | lysine biosynthetic process |
A | 0009086 | biological_process | methionine biosynthetic process |
A | 0009088 | biological_process | threonine biosynthetic process |
A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
A | 0009097 | biological_process | isoleucine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
A | 0019877 | biological_process | diaminopimelate biosynthetic process |
A | 0046983 | molecular_function | protein dimerization activity |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009085 | biological_process | lysine biosynthetic process |
B | 0009086 | biological_process | methionine biosynthetic process |
B | 0009088 | biological_process | threonine biosynthetic process |
B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
B | 0009097 | biological_process | isoleucine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0019877 | biological_process | diaminopimelate biosynthetic process |
B | 0046983 | molecular_function | protein dimerization activity |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAP A 900 |
Chain | Residue |
A | GLY15 |
A | PRO92 |
A | LEU95 |
A | ASN113 |
A | SER187 |
A | GLY188 |
A | ALA189 |
A | GLY190 |
A | ASN333 |
A | THR334 |
A | ALA338 |
A | THR17 |
A | MLA904 |
A | HOH934 |
A | HOH983 |
A | HOH986 |
A | HOH995 |
A | HOH1025 |
A | HOH1038 |
A | HOH1068 |
A | GLY18 |
A | SER19 |
A | VAL20 |
A | ALA41 |
A | SER42 |
A | SER45 |
A | THR74 |
site_id | AC2 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE NAP B 901 |
Chain | Residue |
B | GLY15 |
B | THR17 |
B | GLY18 |
B | SER19 |
B | VAL20 |
B | ALA41 |
B | SER42 |
B | SER45 |
B | THR74 |
B | ALA90 |
B | LEU91 |
B | PRO92 |
B | LEU95 |
B | ASN113 |
B | GLY188 |
B | GLY190 |
B | ASN333 |
B | THR334 |
B | ALA338 |
B | MLA902 |
B | HOH944 |
B | HOH986 |
B | HOH990 |
B | HOH1011 |
B | HOH1020 |
B | HOH1051 |
B | HOH1055 |
B | HOH1092 |
B | HOH1094 |
B | HOH1121 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE MLA B 902 |
Chain | Residue |
B | ASN113 |
B | ARG118 |
B | ASN156 |
B | CYS157 |
B | LYS213 |
B | NAP901 |
B | HOH951 |
B | HOH1020 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE MLA A 903 |
Chain | Residue |
A | PHE206 |
A | ILE207 |
A | ASN209 |
A | GLU210 |
A | GLU211 |
A | GLU212 |
A | HOH914 |
A | HOH964 |
A | HOH1096 |
B | ARG316 |
site_id | AC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE MLA A 904 |
Chain | Residue |
A | SER115 |
A | ARG118 |
A | ASN156 |
A | CYS157 |
A | LYS213 |
A | NAP900 |
A | HOH922 |
A | HOH940 |
A | HOH1025 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MLA B 905 |
Chain | Residue |
A | ARG316 |
B | PHE206 |
B | ILE207 |
B | ASN209 |
B | GLU210 |
B | GLU211 |
B | GLU212 |
B | HOH918 |
B | HOH989 |
B | HOH1053 |
B | HOH1060 |
B | HOH1066 |
Functional Information from PROSITE/UniProt
site_id | PS01103 |
Number of Residues | 15 |
Details | ASD Aspartate-semialdehyde dehydrogenase signature. ISasCnRVavidGHT |
Chain | Residue | Details |
A | ILE237-THR251 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000305|PubMed:16225889 |
Chain | Residue | Details |
A | CYS157 | |
B | CYS157 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:16225889 |
Chain | Residue | Details |
A | HIS250 | |
B | HIS250 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16225889 |
Chain | Residue | Details |
A | THR17 | |
A | SER42 | |
A | SER187 | |
A | ASN333 | |
B | THR17 | |
B | SER42 | |
B | SER187 | |
B | ASN333 |
site_id | SWS_FT_FI4 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02121 |
Chain | Residue | Details |
A | ARG118 | |
B | ARG243 | |
A | GLN184 | |
A | GLU210 | |
A | LYS213 | |
A | ARG243 | |
B | ARG118 | |
B | GLN184 | |
B | GLU210 | |
B | LYS213 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1brm |
Chain | Residue | Details |
A | GLN184 | |
A | CYS157 | |
A | HIS250 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1brm |
Chain | Residue | Details |
B | GLN184 | |
B | CYS157 | |
B | HIS250 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1brm |
Chain | Residue | Details |
A | GLN184 | |
A | CYS157 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1brm |
Chain | Residue | Details |
B | GLN184 | |
B | CYS157 |