1YS4
Structure of Aspartate-Semialdehyde Dehydrogenase from Methanococcus jannaschii
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP A 900 |
| Chain | Residue |
| A | GLY15 |
| A | PRO92 |
| A | LEU95 |
| A | ASN113 |
| A | SER187 |
| A | GLY188 |
| A | ALA189 |
| A | GLY190 |
| A | ASN333 |
| A | THR334 |
| A | ALA338 |
| A | THR17 |
| A | MLA904 |
| A | HOH934 |
| A | HOH983 |
| A | HOH986 |
| A | HOH995 |
| A | HOH1025 |
| A | HOH1038 |
| A | HOH1068 |
| A | GLY18 |
| A | SER19 |
| A | VAL20 |
| A | ALA41 |
| A | SER42 |
| A | SER45 |
| A | THR74 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAP B 901 |
| Chain | Residue |
| B | GLY15 |
| B | THR17 |
| B | GLY18 |
| B | SER19 |
| B | VAL20 |
| B | ALA41 |
| B | SER42 |
| B | SER45 |
| B | THR74 |
| B | ALA90 |
| B | LEU91 |
| B | PRO92 |
| B | LEU95 |
| B | ASN113 |
| B | GLY188 |
| B | GLY190 |
| B | ASN333 |
| B | THR334 |
| B | ALA338 |
| B | MLA902 |
| B | HOH944 |
| B | HOH986 |
| B | HOH990 |
| B | HOH1011 |
| B | HOH1020 |
| B | HOH1051 |
| B | HOH1055 |
| B | HOH1092 |
| B | HOH1094 |
| B | HOH1121 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MLA B 902 |
| Chain | Residue |
| B | ASN113 |
| B | ARG118 |
| B | ASN156 |
| B | CYS157 |
| B | LYS213 |
| B | NAP901 |
| B | HOH951 |
| B | HOH1020 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MLA A 903 |
| Chain | Residue |
| A | PHE206 |
| A | ILE207 |
| A | ASN209 |
| A | GLU210 |
| A | GLU211 |
| A | GLU212 |
| A | HOH914 |
| A | HOH964 |
| A | HOH1096 |
| B | ARG316 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MLA A 904 |
| Chain | Residue |
| A | SER115 |
| A | ARG118 |
| A | ASN156 |
| A | CYS157 |
| A | LYS213 |
| A | NAP900 |
| A | HOH922 |
| A | HOH940 |
| A | HOH1025 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MLA B 905 |
| Chain | Residue |
| A | ARG316 |
| B | PHE206 |
| B | ILE207 |
| B | ASN209 |
| B | GLU210 |
| B | GLU211 |
| B | GLU212 |
| B | HOH918 |
| B | HOH989 |
| B | HOH1053 |
| B | HOH1060 |
| B | HOH1066 |
Functional Information from PROSITE/UniProt
| site_id | PS01103 |
| Number of Residues | 15 |
| Details | ASD Aspartate-semialdehyde dehydrogenase signature. ISasCnRVavidGHT |
| Chain | Residue | Details |
| A | ILE237-THR251 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"16225889","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16225889","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16225889","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| A | GLN184 | |
| A | CYS157 | |
| A | HIS250 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| B | GLN184 | |
| B | CYS157 | |
| B | HIS250 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| A | GLN184 | |
| A | CYS157 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| B | GLN184 | |
| B | CYS157 |
