1YL5
Crystal structure of Mycobacterium tuberculosis dihydrodipicolinate reductase (RV2773C) (crystal form A)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
A | 0009085 | biological_process | lysine biosynthetic process |
A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
A | 0009274 | cellular_component | peptidoglycan-based cell wall |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
A | 0019877 | biological_process | diaminopimelate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
A | 0070402 | molecular_function | NADPH binding |
A | 0070404 | molecular_function | NADH binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
B | 0009085 | biological_process | lysine biosynthetic process |
B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
B | 0009274 | cellular_component | peptidoglycan-based cell wall |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
B | 0019877 | biological_process | diaminopimelate biosynthetic process |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
B | 0070402 | molecular_function | NADPH binding |
B | 0070404 | molecular_function | NADH binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 246 |
Chain | Residue |
A | VAL20 |
A | ALA21 |
A | ALA23 |
A | LEU26 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 246 |
Chain | Residue |
B | VAL20 |
B | ALA21 |
B | ALA23 |
B | LEU26 |
Functional Information from PROSITE/UniProt
site_id | PS01298 |
Number of Residues | 18 |
Details | DAPB Dihydrodipicolinate reductase signature. EViElHhphKaDapSGTA |
Chain | Residue | Details |
A | GLU127-ALA144 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00102 |
Chain | Residue | Details |
A | HIS132 | |
B | HIS132 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000305 |
Chain | Residue | Details |
A | LYS136 | |
B | LYS136 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12962488, ECO:0007744|PDB:1C3V |
Chain | Residue | Details |
A | ALA102 | |
A | LYS136 | |
B | LYS11 | |
B | GLY75 | |
B | ALA102 | |
B | LYS136 | |
A | LYS11 | |
A | GLY75 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12962488, ECO:0000269|PubMed:20057050, ECO:0007744|PDB:1P9L, ECO:0007744|PDB:1YL7 |
Chain | Residue | Details |
A | ASP33 | |
B | ASP33 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:12962488, ECO:0007744|PDB:1C3V, ECO:0007744|PDB:1P9L |
Chain | Residue | Details |
A | HIS133 | |
B | HIS133 | |
B | GLY142 | |
A | GLY142 |