1YI5

Crystal structure of the a-cobratoxin-AChBP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005576	cellular_component	extracellular region
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0043083	cellular_component	synaptic cleft
A	0045202	cellular_component	synapse
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005576	cellular_component	extracellular region
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0043083	cellular_component	synaptic cleft
B	0045202	cellular_component	synapse
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005576	cellular_component	extracellular region
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0043083	cellular_component	synaptic cleft
C	0045202	cellular_component	synapse
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005576	cellular_component	extracellular region
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0043083	cellular_component	synaptic cleft
D	0045202	cellular_component	synapse
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005576	cellular_component	extracellular region
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0043083	cellular_component	synaptic cleft
E	0045202	cellular_component	synapse
F	0005576	cellular_component	extracellular region
F	0030550	molecular_function	acetylcholine receptor inhibitor activity
F	0035821	biological_process	modulation of process of another organism
F	0090729	molecular_function	toxin activity
F	0099106	molecular_function	ion channel regulator activity
G	0005576	cellular_component	extracellular region
G	0030550	molecular_function	acetylcholine receptor inhibitor activity
G	0035821	biological_process	modulation of process of another organism
G	0090729	molecular_function	toxin activity
G	0099106	molecular_function	ion channel regulator activity
H	0005576	cellular_component	extracellular region
H	0030550	molecular_function	acetylcholine receptor inhibitor activity
H	0035821	biological_process	modulation of process of another organism
H	0090729	molecular_function	toxin activity
H	0099106	molecular_function	ion channel regulator activity
I	0005576	cellular_component	extracellular region
I	0030550	molecular_function	acetylcholine receptor inhibitor activity
I	0035821	biological_process	modulation of process of another organism
I	0090729	molecular_function	toxin activity
I	0099106	molecular_function	ion channel regulator activity
J	0005576	cellular_component	extracellular region
J	0030550	molecular_function	acetylcholine receptor inhibitor activity
J	0035821	biological_process	modulation of process of another organism
J	0090729	molecular_function	toxin activity
J	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS00272
Number of Residues	21
Details	SNAKE_TOXIN Snake toxins signature. GCaatCPtvktgvdiq.CCstD

Chain	Residue	Details
F	GLY40-ASP60

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	SITE: Binds to Torpedo AChR => ECO:0000269|PubMed:10574958

Chain	Residue	Details
F	LYS23
J	LYS49
F	LYS49
G	LYS23
G	LYS49
H	LYS23
H	LYS49
I	LYS23
I	LYS49
J	LYS23

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site_id	SWS_FT_FI2
Number of Residues	25
Details	SITE: Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs => ECO:0000269|PubMed:10574958, ECO:0000269|PubMed:10852927

Chain	Residue	Details
F	TRP25
G	PHE65
H	TRP25
H	ASP27
H	PHE29
H	ARG33
H	PHE65
I	TRP25
I	ASP27
I	PHE29
I	ARG33
F	ASP27
I	PHE65
J	TRP25
J	ASP27
J	PHE29
J	ARG33
J	PHE65
F	PHE29
F	ARG33
F	PHE65
G	TRP25
G	ASP27
G	PHE29
G	ARG33

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site_id	SWS_FT_FI3
Number of Residues	10
Details	SITE: Binds to alpha-7/CHRNA7 AChR => ECO:0000269|PubMed:10852927

Chain	Residue	Details
F	ALA28
J	LYS35
F	LYS35
G	ALA28
G	LYS35
H	ALA28
H	LYS35
I	ALA28
I	LYS35
J	ALA28

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site_id	SWS_FT_FI4
Number of Residues	5
Details	SITE: Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs, may be important for inhibition of GABA(A) receptors => ECO:0000269|PubMed:10574958, ECO:0000269|PubMed:10852927, ECO:0000305|PubMed:26221036

Chain	Residue	Details
F	ARG36
G	ARG36
H	ARG36
I	ARG36
J	ARG36

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