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1YHN

Structure basis of RILP recruitment by Rab7

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000166molecular_functionnucleotide binding
A0000421cellular_componentautophagosome membrane
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005794cellular_componentGolgi apparatus
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006622biological_processprotein targeting to lysosome
A0006629biological_processlipid metabolic process
A0006897biological_processendocytosis
A0006914biological_processautophagy
A0007174biological_processepidermal growth factor catabolic process
A0008333biological_processendosome to lysosome transport
A0009617biological_processresponse to bacterium
A0010008cellular_componentendosome membrane
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019076biological_processviral release from host cell
A0022615biological_processprotein to membrane docking
A0030667cellular_componentsecretory granule membrane
A0030670cellular_componentphagocytic vesicle membrane
A0030672cellular_componentsynaptic vesicle membrane
A0030904cellular_componentretromer complex
A0031267molecular_functionsmall GTPase binding
A0031410cellular_componentcytoplasmic vesicle
A0031902cellular_componentlate endosome membrane
A0031966cellular_componentmitochondrial membrane
A0033162cellular_componentmelanosome membrane
A0034045cellular_componentphagophore assembly site membrane
A0042147biological_processretrograde transport, endosome to Golgi
A0043231cellular_componentintracellular membrane-bounded organelle
A0045022biological_processearly endosome to late endosome transport
A0045335cellular_componentphagocytic vesicle
A0045453biological_processbone resorption
A0045732biological_processpositive regulation of protein catabolic process
A0046907biological_processintracellular transport
A0048524biological_processpositive regulation of viral process
A0051650biological_processestablishment of vesicle localization
A0061724biological_processlipophagy
A0070062cellular_componentextracellular exosome
A0090382biological_processphagosome maturation
A0090383biological_processphagosome acidification
A0090385biological_processphagosome-lysosome fusion
A0097208cellular_componentalveolar lamellar body
A0099638biological_processendosome to plasma membrane protein transport
A1903542biological_processnegative regulation of exosomal secretion
A1903543biological_processpositive regulation of exosomal secretion
A1905366biological_processnegative regulation of intralumenal vesicle formation
A1905394molecular_functionretromer complex binding
B0046983molecular_functionprotein dimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 302
ChainResidue
ATHR22
ATHR40
AASP63
ATHR64
AGTP301

site_idAC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GTP A 301
ChainResidue
ALYS21
ATHR22
ASER23
APHE33
ASER34
AASN35
ATYR37
ATHR40
ATHR64
AALA65
AGLY66
AASN125
ALYS126
AASP128
ALEU129
ASER155
AALA156
ALYS157
AMG302
AHOH311
ASER17
AGLY18
AVAL19
AGLY20

Functional Information from PROSITE/UniProt
site_idPS00675
Number of Residues14
DetailsSIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VIIlGDSGVGKtsL
ChainResidueDetails
AVAL11-LEU24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:15933719, ECO:0000269|PubMed:20028791
ChainResidueDetails
AGLY15
ASER34
AASP63
AASN125
AALA156

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylthreonine => ECO:0007744|PubMed:25944712
ChainResidueDetails
ATHR2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER72

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250
ChainResidueDetails
ACYS207

site_idSWS_FT_FI5
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250
ChainResidueDetails
ACYS205
ACYS207

site_idSWS_FT_FI6
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36476874
ChainResidueDetails
ALYS191
ALYS194

218853

PDB entries from 2024-04-24

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