1YAT
IMPROVED CALCINEURIN INHIBITION BY YEAST FKBP12-DRUG COMPLEXES. CRYSTALLOGRAPHIC AND FUNCTIONAL ANALYSIS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001228 | molecular_function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005527 | molecular_function | macrolide binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006366 | biological_process | transcription by RNA polymerase II |
| A | 0006457 | biological_process | protein folding |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0044183 | molecular_function | protein folding chaperone |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0070651 | biological_process | nonfunctional rRNA decay |
| A | 1901710 | biological_process | regulation of homoserine biosynthetic process |
| A | 1901711 | biological_process | negative regulation of homoserine biosynthetic process |
| A | 1903332 | biological_process | regulation of protein folding |
Functional Information from PDB Data
| site_id | 506 |
| Number of Residues | 12 |
| Details |
| Chain | Residue |
| A | TYR26 |
| A | ILE91 |
| A | TYR82 |
| A | PHE99 |
| A | PHE36 |
| A | ASP37 |
| A | PHE46 |
| A | GLN54 |
| A | VAL55 |
| A | ILE56 |
| A | TRP59 |
| A | PHE87 |
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FK5 A 108 |
| Chain | Residue |
| A | TYR26 |
| A | PHE36 |
| A | ASP37 |
| A | ARG42 |
| A | PHE46 |
| A | GLN54 |
| A | VAL55 |
| A | ILE56 |
| A | TRP59 |
| A | ALA81 |
| A | TYR82 |
| A | PRO88 |
| A | ILE91 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1d6o |
| Chain | Residue | Details |
| A | ILE56 | |
| A | TYR82 | |
| A | ASP37 |
