1YAK
Complex of Bacillus subtilis TenA with 4-amino-2-methyl-5-hydroxymethylpyrimidine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006772 | biological_process | thiamine metabolic process |
| A | 0009228 | biological_process | thiamine biosynthetic process |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0050334 | molecular_function | thiaminase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006772 | biological_process | thiamine metabolic process |
| B | 0009228 | biological_process | thiamine biosynthetic process |
| B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0050334 | molecular_function | thiaminase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006772 | biological_process | thiamine metabolic process |
| C | 0009228 | biological_process | thiamine biosynthetic process |
| C | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0050334 | molecular_function | thiaminase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006772 | biological_process | thiamine metabolic process |
| D | 0009228 | biological_process | thiamine biosynthetic process |
| D | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0050334 | molecular_function | thiaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HMH A 301 |
| Chain | Residue |
| A | ASP44 |
| A | TYR47 |
| A | LEU48 |
| A | CYS135 |
| A | TYR139 |
| A | TYR163 |
| A | GLU205 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HMH D 302 |
| Chain | Residue |
| D | LEU48 |
| D | CYS135 |
| D | TYR139 |
| D | TYR163 |
| D | GLU205 |
| D | ASP44 |
| D | TYR47 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HMH B 303 |
| Chain | Residue |
| B | ASP44 |
| B | TYR47 |
| B | CYS135 |
| B | TYR139 |
| B | TYR163 |
| B | GLU205 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HMH C 304 |
| Chain | Residue |
| C | ASP44 |
| C | TYR47 |
| C | CYS135 |
| C | TYR139 |
| C | TYR163 |
| C | GLU205 |
| C | HOH2069 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"18054064","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"18054064","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15709744","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2004","submissionDatabase":"PDB data bank","title":"Crystal structure of THI-4 protein from Bacillus subtilis.","authors":["Rajan S.S.","Shuvalova L.","Yang X.","Hussar C.","Collart F.","Anderson W.F."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Increases nucleophilicity of active site Cys","evidences":[{"source":"PubMed","id":"18054064","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
