1Y63

Initial crystal structural analysis of a probable kinase from Leishmania major Friedlin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0004017	molecular_function	AMP kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005929	cellular_component	cilium
A	0006364	biological_process	rRNA processing
A	0006979	biological_process	response to oxidative stress
A	0009267	biological_process	cellular response to starvation
A	0010494	cellular_component	cytoplasmic stress granule
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030490	biological_process	maturation of SSU-rRNA
A	0031981	cellular_component	nuclear lumen
A	0042134	molecular_function	rRNA primary transcript binding
A	0042254	biological_process	ribosome biogenesis
A	0042274	biological_process	ribosomal small subunit biogenesis
A	0046872	molecular_function	metal ion binding
A	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 302

Chain	Residue
A	THR24
A	ADP301
A	HOH1005
A	HOH1008
A	HOH1013
A	HOH1014

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 311

Chain	Residue
A	HOH1030
A	HOH1031
A	HOH1038
A	GLU28
A	HIS39
A	HOH1026

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 351

Chain	Residue
A	ASP70
A	ASP150
A	HOH1087
A	HOH1111
A	HOH1132
A	HOH1137

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 352

Chain	Residue
A	GLU125
A	HOH1054
A	HOH1080
A	HOH1117
A	HOH1130

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 353

Chain	Residue
A	GLU98
A	ALA147
A	HOH1002
A	HOH1002
A	HOH1033
A	HOH1034
A	HOH1043

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 354

Chain	Residue
A	GLN38
A	SER82
A	ARG83
A	HIS86

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MN A 355

Chain	Residue
A	ASN131

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN A 356

Chain	Residue
A	ILE64
A	TYR90
A	HIS91

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 401

Chain	Residue
A	TYR90
A	HIS91
A	HOH1001

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 402

Chain	Residue
A	LEU161

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 403

Chain	Residue
A	ASP35
A	HOH1082
A	HOH1089

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 404

Chain	Residue
A	GLU41

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 405

Chain	Residue
A	TYR123
A	ARG128
A	ASN131

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 501

Chain	Residue
A	GLU94
A	GLU94
A	HOH1107
A	HOH1107
A	HOH1157

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 502

Chain	Residue
A	ASP146
A	HOH1088

---

site_id	BC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP A 301

Chain	Residue
A	GLY20
A	THR21
A	GLY22
A	LYS23
A	THR24
A	SER25
A	PHE115
A	ARG117
A	THR119
A	ARG128
A	ASN158
A	ASP159
A	THR160
A	LEU161
A	MET164
A	MN302
A	HOH1005
A	HOH1008
A	HOH1013
A	HOH1029
A	HOH1032
A	HOH1037

---