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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1Y2B

Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	HIS164
A	HIS200
A	ASP201
A	ASP318
A	HOH1007
A	HOH1008

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	HOH1005
A	HOH1006
A	HOH1007
A	ASP201
A	HOH1003
A	HOH1004

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 1001

Chain	Residue
B	HIS164
B	HIS200
B	ASP201
B	ASP318
B	HOH2007
B	HOH2008

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1002

Chain	Residue
B	ASP201
B	HOH2003
B	HOH2004
B	HOH2005
B	HOH2006
B	HOH2007

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DEE B 501

Chain	Residue
B	TYR159
B	ASN321
B	THR333
B	ILE336
B	GLN369
B	PHE372

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DEE A 502

Chain	Residue
A	TYR159
A	ASN321
A	THR333
A	ILE336
A	GLN369
A	PHE372

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 601

Chain	Residue
A	PRO411
B	ARG330
B	GLU366
B	TYR406
B	HOH2058

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 602

Chain	Residue
A	LYS262
A	ILE265
A	ASP266
A	HOH1030

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 606

Chain	Residue
B	HOH2086

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 607

Chain	Residue
A	ASN115
A	GLU150
A	ASP151
A	TYR153
A	ASN162
A	EDO615
A	HOH1157
A	HOH1223
B	GLN407

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 608

Chain	Residue
B	SER208
B	PRO356
B	HOH2032
B	HOH2067

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 612

Chain	Residue
A	PRO179
A	HIS389
A	PRO390
A	ASP391

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 615

Chain	Residue
A	ASN115
A	ALA155
A	ASN162
A	ILE163
A	EDO607
A	HOH1157

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 616

Chain	Residue
A	LEU175
A	THR178
A	TRP384
A	ASP391
A	ALA392
A	HOH1134

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 617

Chain	Residue
B	ARG257
B	ARG261
B	EDO618
B	HOH2148

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 618

Chain	Residue
B	ARG257
B	GLN258
B	ARG261
B	EDO617
B	HOH2160
B	HOH2205

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 619

Chain	Residue
A	ALA183
A	VAL184
A	HOH1121
B	GLY114
B	ASN115
B	ARG116
B	HOH2144
B	HOH2155

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 620

Chain	Residue
A	PHE238
A	PHE249
A	ARG257
A	ARG261
A	HOH1168

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 622

Chain	Residue
A	PHE340
A	PRO356
A	HOH1057
A	SER208

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 624

Chain	Residue
A	GLU218
B	HOH2025

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 625

Chain	Residue
B	LYS262
B	ILE265
B	ASP266
B	HOH2047

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 627

Chain	Residue
A	HOH1009
B	ASP401
B	ASN402
B	HOH2114

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 628

Chain	Residue
A	GLU366
A	HOH1070

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 629

Chain	Residue
A	ASP151
A	HIS152
B	GLY371
B	ASP374
B	TYR375
B	HOH2100
B	HOH2192

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 633

Chain	Residue
A	HIS154
A	ASP203
A	PRO205

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS200-PHE211

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250\|UniProtKB:Q07343

Chain	Residue	Details
A	HIS160
B	HIS160

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:14609333, ECO:0000269\|PubMed:15260978, ECO:0007744\|PDB:1PTW, ECO:0007744\|PDB:1TB7

Chain	Residue	Details
A	HIS160
A	ASN321
A	GLN369
B	HIS160
B	ASN321
B	GLN369

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:14609333, ECO:0000269\|PubMed:15260978, ECO:0000269\|PubMed:15576036, ECO:0000269\|PubMed:17582435, ECO:0007744\|PDB:1PTW, ECO:0007744\|PDB:1TB7, ECO:0007744\|PDB:1TBB, ECO:0007744\|PDB:1XOM, ECO:0007744\|PDB:1XON, ECO:0007744\|PDB:1XOQ, ECO:0007744\|PDB:2PW3

Chain	Residue	Details
A	HIS164
B	HIS164

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:14609333, ECO:0000269\|PubMed:15260978, ECO:0000269\|PubMed:15576036, ECO:0000269\|PubMed:17582435, ECO:0007744\|PDB:1PTW, ECO:0007744\|PDB:1TB7, ECO:0007744\|PDB:1TBB, ECO:0007744\|PDB:1XOM, ECO:0007744\|PDB:1XON, ECO:0007744\|PDB:1XOQ, ECO:0007744\|PDB:1XOR, ECO:0007744\|PDB:2PW3

Chain	Residue	Details
A	HIS200
A	ASP318
B	HIS200
B	ASP318

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:14609333, ECO:0007744\|PDB:1PTW

Chain	Residue	Details
A	ASP201
A	PHE372
B	ASP201
B	PHE372

219140

PDB entries from 2024-05-01

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