Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE |
| Chain | Residue |
| A | PHE229 |
| A | GLY406 |
| A | VAL407 |
| A | GLY408 |
| A | ARG409 |
| A | GLN446 |
| A | HOH632 |
| A | HOH745 |
| B | HOH705 |
| C | NH2107 |
| C | HOH624 |
| A | ARG230 |
| A | ASP231 |
| A | ILE232 |
| A | ASP356 |
| A | GLN357 |
| A | CYS403 |
| A | ARG404 |
| A | ALA405 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE |
| Chain | Residue |
| A | ARG278 |
| A | ARG295 |
| A | LYS342 |
| A | THR343 |
| A | MET382 |
| A | LYS386 |
| A | SER388 |
| A | SER389 |
| A | HOH774 |
| B | SER468 |
| D | NH27 |
| D | HOH539 |
| D | HOH540 |
| D | HOH542 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE |
| Chain | Residue |
| A | HOH749 |
| B | PHE229 |
| B | ARG230 |
| B | ASP231 |
| B | ILE232 |
| B | ASP356 |
| B | GLN357 |
| B | CYS403 |
| B | ARG404 |
| B | ALA405 |
| B | GLY406 |
| B | VAL407 |
| B | GLY408 |
| B | ARG409 |
| B | GLN446 |
| E | NH2107 |
| E | HOH783 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE |
| Chain | Residue |
| A | SER468 |
| B | ARG278 |
| B | ARG295 |
| B | LYS342 |
| B | THR343 |
| B | ILE344 |
| B | SER345 |
| B | LYS386 |
| B | SER388 |
| B | SER389 |
| B | HOH709 |
| F | NH27 |
| F | HOH642 |
| F | HOH644 |
| F | HOH818 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCraGvgRTA |
| Chain | Residue | Details |
| A | ILE401-ALA411 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate"} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | ASP356 | |
| A | THR410 | |
| A | CYS403 | |
| A | ARG409 | |
| A | GLU290 | |
| A | HIS402 | |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | ASP356 | |
| B | THR410 | |
| B | CYS403 | |
| B | ARG409 | |
| B | GLU290 | |
| B | HIS402 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | ASP356 | |
| A | THR410 | |
| A | CYS403 | |
| A | ARG409 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | ASP356 | |
| B | THR410 | |
| B | CYS403 | |
| B | ARG409 | |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 47 |
| Chain | Residue | Details |
| A | GLU290 | steric role |
| A | TRP354 | steric role |
| A | ASP356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS402 | electrostatic stabiliser, hydrogen bond donor |
| A | CYS403 | nucleofuge, nucleophile |
| A | ARG409 | electrostatic stabiliser, hydrogen bond donor |
| A | THR410 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 47 |
| Chain | Residue | Details |
| B | GLU290 | steric role |
| B | TRP354 | steric role |
| B | ASP356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | HIS402 | electrostatic stabiliser, hydrogen bond donor |
| B | CYS403 | nucleofuge, nucleophile |
| B | ARG409 | electrostatic stabiliser, hydrogen bond donor |
| B | THR410 | electrostatic stabiliser, hydrogen bond donor |
