1XXI
ADP Bound E. coli Clamp Loader Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003689 | molecular_function | DNA clamp loader activity |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0030894 | cellular_component | replisome |
| A | 0034061 | molecular_function | DNA polymerase activity |
| A | 0043846 | cellular_component | DNA polymerase III, clamp loader complex |
| A | 0071897 | biological_process | DNA biosynthetic process |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006260 | biological_process | DNA replication |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006260 | biological_process | DNA replication |
| C | 0009360 | cellular_component | DNA polymerase III complex |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006260 | biological_process | DNA replication |
| D | 0009360 | cellular_component | DNA polymerase III complex |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003689 | molecular_function | DNA clamp loader activity |
| E | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0006260 | biological_process | DNA replication |
| E | 0006261 | biological_process | DNA-templated DNA replication |
| E | 0008408 | molecular_function | 3'-5' exonuclease activity |
| E | 0009360 | cellular_component | DNA polymerase III complex |
| E | 0030894 | cellular_component | replisome |
| E | 0034061 | molecular_function | DNA polymerase activity |
| E | 0043846 | cellular_component | DNA polymerase III, clamp loader complex |
| E | 0071897 | biological_process | DNA biosynthetic process |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003689 | molecular_function | DNA clamp loader activity |
| F | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0006260 | biological_process | DNA replication |
| F | 0006261 | biological_process | DNA-templated DNA replication |
| F | 0009360 | cellular_component | DNA polymerase III complex |
| F | 0030894 | cellular_component | replisome |
| F | 0034061 | molecular_function | DNA polymerase activity |
| F | 0043846 | cellular_component | DNA polymerase III, clamp loader complex |
| F | 0071897 | biological_process | DNA biosynthetic process |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0006260 | biological_process | DNA replication |
| G | 0009360 | cellular_component | DNA polymerase III complex |
| G | 0016887 | molecular_function | ATP hydrolysis activity |
| H | 0003677 | molecular_function | DNA binding |
| H | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0006260 | biological_process | DNA replication |
| H | 0009360 | cellular_component | DNA polymerase III complex |
| H | 0016887 | molecular_function | ATP hydrolysis activity |
| I | 0003677 | molecular_function | DNA binding |
| I | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| I | 0005524 | molecular_function | ATP binding |
| I | 0006260 | biological_process | DNA replication |
| I | 0009360 | cellular_component | DNA polymerase III complex |
| I | 0016887 | molecular_function | ATP hydrolysis activity |
| J | 0003677 | molecular_function | DNA binding |
| J | 0003689 | molecular_function | DNA clamp loader activity |
| J | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0006260 | biological_process | DNA replication |
| J | 0006261 | biological_process | DNA-templated DNA replication |
| J | 0008408 | molecular_function | 3'-5' exonuclease activity |
| J | 0009360 | cellular_component | DNA polymerase III complex |
| J | 0030894 | cellular_component | replisome |
| J | 0034061 | molecular_function | DNA polymerase activity |
| J | 0043846 | cellular_component | DNA polymerase III, clamp loader complex |
| J | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 1300 |
| Chain | Residue |
| C | THR46 |
| C | ARG47 |
| C | GLY48 |
| C | VAL49 |
| C | LYS51 |
| C | THR52 |
| C | ARG215 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 401 |
| Chain | Residue |
| C | CYS76 |
| C | CYS79 |
| C | CYS64 |
| C | CYS73 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 402 |
| Chain | Residue |
| D | CYS64 |
| D | CYS73 |
| D | GLY74 |
| D | CYS76 |
| D | CYS79 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 403 |
| Chain | Residue |
| B | CYS64 |
| B | CYS73 |
| B | GLY74 |
| B | CYS76 |
| B | CYS79 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 404 |
| Chain | Residue |
| E | CYS50 |
| E | CYS59 |
| E | CYS62 |
| E | CYS65 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN H 405 |
| Chain | Residue |
| H | CYS64 |
| H | CYS73 |
| H | CYS76 |
| H | CYS79 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN I 406 |
| Chain | Residue |
| I | CYS64 |
| I | CYS73 |
| I | GLY74 |
| I | CYS76 |
| I | CYS79 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN G 407 |
| Chain | Residue |
| G | CYS64 |
| G | CYS73 |
| G | GLY74 |
| G | CYS76 |
| G | CYS79 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN J 408 |
| Chain | Residue |
| J | CYS50 |
| J | CYS59 |
| J | CYS62 |
| J | CYS65 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP D 801 |
| Chain | Residue |
| D | ALA7 |
| D | TRP10 |
| D | ARG11 |
| D | PRO12 |
| D | VAL19 |
| D | GLY48 |
| D | VAL49 |
| D | GLY50 |
| D | LYS51 |
| D | THR52 |
| D | SER53 |
| D | LEU214 |
| D | ARG215 |
| D | LEU218 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP B 802 |
| Chain | Residue |
| B | ALA7 |
| B | TRP10 |
| B | ARG11 |
| B | PRO12 |
| B | VAL18 |
| B | VAL19 |
| B | GLY48 |
| B | VAL49 |
| B | GLY50 |
| B | LYS51 |
| B | THR52 |
| B | SER53 |
| B | LEU214 |
| B | ARG215 |
| B | LEU218 |
| site_id | BC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP I 803 |
| Chain | Residue |
| I | ALA7 |
| I | TRP10 |
| I | ARG11 |
| I | VAL18 |
| I | VAL19 |
| I | GLY48 |
| I | VAL49 |
| I | GLY50 |
| I | LYS51 |
| I | THR52 |
| I | SER53 |
| I | LEU214 |
| I | ARG215 |
| I | LEU218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY45 | |
| C | GLY45 | |
| D | GLY45 | |
| G | GLY45 | |
| H | GLY45 | |
| I | GLY45 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11525729, ECO:0007744|PDB:1JR3 |
| Chain | Residue | Details |
| B | CYS64 | |
| D | CYS73 | |
| D | CYS76 | |
| D | CYS79 | |
| G | CYS64 | |
| G | CYS73 | |
| G | CYS76 | |
| G | CYS79 | |
| H | CYS64 | |
| H | CYS73 | |
| H | CYS76 | |
| B | CYS73 | |
| H | CYS79 | |
| I | CYS64 | |
| I | CYS73 | |
| I | CYS76 | |
| I | CYS79 | |
| B | CYS76 | |
| B | CYS79 | |
| C | CYS64 | |
| C | CYS73 | |
| C | CYS76 | |
| C | CYS79 | |
| D | CYS64 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| B | VAL253 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| G | ARG215 | |
| G | LYS51 | |
| G | LYS141 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| H | ARG215 | |
| H | LYS51 | |
| H | LYS141 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| I | ARG215 | |
| I | LYS51 | |
| I | LYS141 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| B | ARG215 | |
| B | THR157 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| C | ARG215 | |
| C | THR157 |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| D | ARG215 | |
| D | THR157 |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| G | ARG215 | |
| G | THR157 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| H | ARG215 | |
| H | THR157 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| I | ARG215 | |
| I | THR157 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| C | VAL253 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| D | VAL253 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| G | VAL253 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| H | VAL253 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| I | VAL253 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| B | ARG215 | |
| B | LYS51 | |
| B | LYS141 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| C | ARG215 | |
| C | LYS51 | |
| C | LYS141 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1g8p |
| Chain | Residue | Details |
| D | ARG215 | |
| D | LYS51 | |
| D | LYS141 |
