1XW9
Drosophila thioredoxin, oxidized, P21
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008340 | biological_process | determination of adult lifespan |
| A | 0015035 | molecular_function | protein-disulfide reductase activity |
| A | 0015036 | molecular_function | disulfide oxidoreductase activity |
| A | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050832 | biological_process | defense response to fungus |
| B | 0005634 | cellular_component | nucleus |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008340 | biological_process | determination of adult lifespan |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0015036 | molecular_function | disulfide oxidoreductase activity |
| B | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050832 | biological_process | defense response to fungus |
| C | 0005634 | cellular_component | nucleus |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0008340 | biological_process | determination of adult lifespan |
| C | 0015035 | molecular_function | protein-disulfide reductase activity |
| C | 0015036 | molecular_function | disulfide oxidoreductase activity |
| C | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| C | 0045454 | biological_process | cell redox homeostasis |
| C | 0050832 | biological_process | defense response to fungus |
| D | 0005634 | cellular_component | nucleus |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0008340 | biological_process | determination of adult lifespan |
| D | 0015035 | molecular_function | protein-disulfide reductase activity |
| D | 0015036 | molecular_function | disulfide oxidoreductase activity |
| D | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| D | 0045454 | biological_process | cell redox homeostasis |
| D | 0050832 | biological_process | defense response to fungus |
Functional Information from PROSITE/UniProt
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. VLdFFatWCGPCKmIspkL |
| Chain | Residue | Details |
| A | VAL24-LEU42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:Q9BRA2 |
| Chain | Residue | Details |
| A | CYS32 | |
| A | CYS35 | |
| B | CYS32 | |
| B | CYS35 | |
| C | CYS32 | |
| C | CYS35 | |
| D | CYS32 | |
| D | CYS35 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Deprotonates C-terminal active site Cys => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP26 | |
| B | ASP26 | |
| C | ASP26 | |
| D | ASP26 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | SITE: Contributes to redox potential value => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY33 | |
| A | PRO34 | |
| B | GLY33 | |
| B | PRO34 | |
| C | GLY33 | |
| C | PRO34 | |
| D | GLY33 | |
| D | PRO34 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| A | PRO34 | |
| A | CYS35 | |
| A | CYS32 | |
| A | GLY33 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| B | PRO34 | |
| B | CYS35 | |
| B | CYS32 | |
| B | GLY33 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| C | PRO34 | |
| C | CYS35 | |
| C | CYS32 | |
| C | GLY33 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| D | PRO34 | |
| D | CYS35 | |
| D | CYS32 | |
| D | GLY33 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| A | CYS35 | |
| A | CYS32 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| B | CYS35 | |
| B | CYS32 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| C | CYS35 | |
| C | CYS32 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| D | CYS35 | |
| D | CYS32 |
