Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1XTU

Sulfolobus solfataricus uracil phosphoribosyltransferase in complex with uridine 5'-monophosphate (UMP) and cytidine 5'-triphosphate (CTP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0004845	molecular_function	uracil phosphoribosyltransferase activity
A	0005525	molecular_function	GTP binding
A	0005829	cellular_component	cytosol
A	0006178	biological_process	guanine salvage
A	0006223	biological_process	uracil salvage
A	0008655	biological_process	pyrimidine-containing compound salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0044206	biological_process	UMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0004845	molecular_function	uracil phosphoribosyltransferase activity
B	0005525	molecular_function	GTP binding
B	0005829	cellular_component	cytosol
B	0006178	biological_process	guanine salvage
B	0006223	biological_process	uracil salvage
B	0008655	biological_process	pyrimidine-containing compound salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0044206	biological_process	UMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
C	0000287	molecular_function	magnesium ion binding
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0004845	molecular_function	uracil phosphoribosyltransferase activity
C	0005525	molecular_function	GTP binding
C	0005829	cellular_component	cytosol
C	0006178	biological_process	guanine salvage
C	0006223	biological_process	uracil salvage
C	0008655	biological_process	pyrimidine-containing compound salvage
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0044206	biological_process	UMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
D	0000287	molecular_function	magnesium ion binding
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0004845	molecular_function	uracil phosphoribosyltransferase activity
D	0005525	molecular_function	GTP binding
D	0005829	cellular_component	cytosol
D	0006178	biological_process	guanine salvage
D	0006223	biological_process	uracil salvage
D	0008655	biological_process	pyrimidine-containing compound salvage
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0044206	biological_process	UMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
E	0000287	molecular_function	magnesium ion binding
E	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
E	0004845	molecular_function	uracil phosphoribosyltransferase activity
E	0005525	molecular_function	GTP binding
E	0005829	cellular_component	cytosol
E	0006178	biological_process	guanine salvage
E	0006223	biological_process	uracil salvage
E	0008655	biological_process	pyrimidine-containing compound salvage
E	0016757	molecular_function	glycosyltransferase activity
E	0032263	biological_process	GMP salvage
E	0032264	biological_process	IMP salvage
E	0044206	biological_process	UMP salvage
E	0046100	biological_process	hypoxanthine metabolic process
F	0000287	molecular_function	magnesium ion binding
F	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
F	0004845	molecular_function	uracil phosphoribosyltransferase activity
F	0005525	molecular_function	GTP binding
F	0005829	cellular_component	cytosol
F	0006178	biological_process	guanine salvage
F	0006223	biological_process	uracil salvage
F	0008655	biological_process	pyrimidine-containing compound salvage
F	0016757	molecular_function	glycosyltransferase activity
F	0032263	biological_process	GMP salvage
F	0032264	biological_process	IMP salvage
F	0044206	biological_process	UMP salvage
F	0046100	biological_process	hypoxanthine metabolic process
G	0000287	molecular_function	magnesium ion binding
G	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
G	0004845	molecular_function	uracil phosphoribosyltransferase activity
G	0005525	molecular_function	GTP binding
G	0005829	cellular_component	cytosol
G	0006178	biological_process	guanine salvage
G	0006223	biological_process	uracil salvage
G	0008655	biological_process	pyrimidine-containing compound salvage
G	0016757	molecular_function	glycosyltransferase activity
G	0032263	biological_process	GMP salvage
G	0032264	biological_process	IMP salvage
G	0044206	biological_process	UMP salvage
G	0046100	biological_process	hypoxanthine metabolic process
H	0000287	molecular_function	magnesium ion binding
H	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
H	0004845	molecular_function	uracil phosphoribosyltransferase activity
H	0005525	molecular_function	GTP binding
H	0005829	cellular_component	cytosol
H	0006178	biological_process	guanine salvage
H	0006223	biological_process	uracil salvage
H	0008655	biological_process	pyrimidine-containing compound salvage
H	0016757	molecular_function	glycosyltransferase activity
H	0032263	biological_process	GMP salvage
H	0032264	biological_process	IMP salvage
H	0044206	biological_process	UMP salvage
H	0046100	biological_process	hypoxanthine metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P A 1250

Chain	Residue
A	ARG105
A	GLY201
A	TYR202
A	ILE203
A	GLY208
A	ASP209
A	ALA210
A	ASP140
A	MET142
A	ILE143
A	ALA144
A	THR145
A	ALA146
A	SER147
A	THR148

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P B 2250

Chain	Residue
B	ARG105
B	ASP140
B	MET142
B	ILE143
B	ALA144
B	THR145
B	ALA146
B	SER147
B	THR148
B	GLY201
B	TYR202
B	ILE203
B	GLY208
B	ASP209
B	ALA210

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P C 3250

Chain	Residue
C	ARG105
C	ASP140
C	MET142
C	ILE143
C	ALA144
C	THR145
C	ALA146
C	SER147
C	THR148
C	GLY201
C	TYR202
C	ILE203
C	GLY208
C	ASP209
C	ALA210

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P D 4250

Chain	Residue
D	ARG105
D	ASP140
D	MET142
D	ILE143
D	ALA144
D	THR145
D	ALA146
D	SER147
D	THR148
D	GLY201
D	TYR202
D	ILE203
D	GLY208
D	ASP209
D	ALA210

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P E 5250

Chain	Residue
E	ARG105
E	ASP140
E	MET142
E	ILE143
E	ALA144
E	THR145
E	ALA146
E	SER147
E	THR148
E	GLY201
E	TYR202
E	ILE203
E	GLY208
E	ASP209
E	ALA210

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P F 6250

Chain	Residue
F	ARG105
F	ASP140
F	MET142
F	ILE143
F	ALA144
F	THR145
F	ALA146
F	SER147
F	THR148
F	GLY201
F	TYR202
F	ILE203
F	GLY208
F	ASP209
F	ALA210

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P G 7250

Chain	Residue
G	GLY201
G	TYR202
G	ILE203
G	GLY208
G	ASP209
G	ALA210
G	ARG105
G	ASP140
G	MET142
G	ILE143
G	ALA144
G	THR145
G	ALA146
G	SER147
G	THR148

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U5P H 8250

Chain	Residue
H	ARG105
H	ASP140
H	MET142
H	ILE143
H	ALA144
H	THR145
H	ALA146
H	SER147
H	THR148
H	GLY201
H	TYR202
H	ILE203
H	GLY208
H	ASP209
H	ALA210

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CTP A 1260

Chain	Residue
A	ARG29
A	LYS30
A	VAL33
A	ARG37
A	GLU87
D	CTP4260
E	ARG37
E	LYS91
E	CTP5260
H	GLU87
H	LEU90
H	LYS91
H	PRO94
H	ALA96
H	CTP8260

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CTP G 2260

Chain	Residue
B	ARG29
B	LYS30
B	VAL33
B	ARG37
B	GLU87
C	CTP3260
F	ARG37
F	LYS91
F	CTP6260
G	GLU87
G	LEU90
G	LYS91
G	PRO94
G	ALA96
G	CTP7260

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CTP C 3260

Chain	Residue
C	ARG29
C	LYS30
C	VAL33
C	ARG37
C	GLU87
F	GLU87
F	LYS91
F	PRO94
F	ALA96
F	CTP6260
G	ARG37
G	LYS91
G	CTP2260
G	CTP7260

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CTP D 4260

Chain	Residue
A	CTP1260
D	ARG29
D	LYS30
D	VAL33
D	ARG37
D	GLU87
E	GLU87
E	LYS91
E	PRO94
E	ALA96
E	CTP5260
H	ARG37
H	LYS91
H	CTP8260

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CTP E 5260

Chain	Residue
A	LYS91
A	CTP1260
D	GLU87
D	LYS91
D	PRO94
D	ALA96
D	CTP4260
E	ARG29
E	LYS30
E	VAL33
E	ARG37
E	GLU87
H	CTP8260

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CTP F 6260

Chain	Residue
B	ARG37
B	LYS91
C	GLU87
C	LYS91
C	PRO94
C	ALA96
C	CTP3260
F	ARG29
F	LYS30
F	VAL33
F	ARG37
F	GLU87
G	CTP2260
G	CTP7260

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CTP G 7260

Chain	Residue
B	GLU87
B	LEU90
B	LYS91
B	PRO94
B	ALA96
C	ARG37
C	LYS91
C	CTP3260
F	CTP6260
G	ARG29
G	LYS30
G	VAL33
G	ARG37
G	GLU87
G	CTP2260

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CTP H 8260

Chain	Residue
A	GLU87
A	LEU90
A	LYS91
A	PRO94
A	ALA96
A	CTP1260
D	ARG37
D	LYS91
D	CTP4260
E	CTP5260
H	ARG29
H	LYS30
H	VAL33
H	ARG37
H	GLU87

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	BINDING:

Chain	Residue	Details
A	ARG29
A	ASP209
B	ARG29
B	LYS30
B	ARG37
B	ARG80
B	GLU87
B	ARG105
B	ASP140
B	ILE203
B	GLY208
A	LYS30
B	ASP209
C	ARG29
C	LYS30
C	ARG37
C	ARG80
C	GLU87
C	ARG105
C	ASP140
C	ILE203
C	GLY208
A	ARG37
C	ASP209
D	ARG29
D	LYS30
D	ARG37
D	ARG80
D	GLU87
D	ARG105
D	ASP140
D	ILE203
D	GLY208
A	ARG80
D	ASP209
E	ARG29
E	LYS30
E	ARG37
E	ARG80
E	GLU87
E	ARG105
E	ASP140
E	ILE203
E	GLY208
A	GLU87
E	ASP209
F	ARG29
F	LYS30
F	ARG37
F	ARG80
F	GLU87
F	ARG105
F	ASP140
F	ILE203
F	GLY208
A	ARG105
F	ASP209
G	ARG29
G	LYS30
G	ARG37
G	ARG80
G	GLU87
G	ARG105
G	ASP140
G	ILE203
G	GLY208
A	ASP140
G	ASP209
H	ARG29
H	LYS30
H	ARG37
H	ARG80
H	GLU87
H	ARG105
H	ASP140
H	ILE203
H	GLY208
A	ILE203
H	ASP209
A	GLY208

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)