1XSL

Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0006281	biological_process	DNA repair
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034061	molecular_function	DNA polymerase activity
I	0003677	molecular_function	DNA binding
I	0003887	molecular_function	DNA-directed DNA polymerase activity
I	0006281	biological_process	DNA repair
I	0016779	molecular_function	nucleotidyltransferase activity
I	0034061	molecular_function	DNA polymerase activity
M	0003677	molecular_function	DNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0006281	biological_process	DNA repair
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 961

Chain	Residue
A	SER339
A	ILE341
A	ALA344
C	DG5
C	HOH8
C	HOH156

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 962

Chain	Residue
E	HOH1016
G	DG5
G	HOH508
E	SER339
E	ILE341
E	ALA344

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA I 963

Chain	Residue
I	SER339
I	ILE341
I	ALA344
K	DG5
K	HOH303
K	HOH875

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA M 964

Chain	Residue
M	SER339
M	ILE341
M	ALA344
M	HOH978
O	DG5
O	HOH39

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA J 965

Chain	Residue
J	HOH641
J	HOH642
J	HOH643
J	HOH644
L	HOH640
L	HOH645

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA N 966

Chain	Residue
N	HOH943
N	HOH944
N	HOH945
P	HOH940

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 991

Chain	Residue
B	HOH700
B	HOH702
B	HOH703
B	HOH704
B	HOH705
D	HOH701

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 992

Chain	Residue
F	HOH854
F	HOH857
F	HOH858
F	HOH859
H	HOH855
H	HOH856

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 993

Chain	Residue
H	HOH868
H	HOH871
H	HOH872
H	HOH873
H	HOH874
L	HOH870

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CAC D 950

Chain	Residue
D	DC3
D	DG4
P	DG4

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865

Chain	Residue	Details
A	LYS312
E	LYS312
I	LYS312
M	LYS312

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ARG386
I	SER417
I	GLY426
I	ASN513
M	ARG386
M	SER417
M	GLY426
M	ASN513
A	SER417
A	GLY426
A	ASN513
E	ARG386
E	SER417
E	GLY426
E	ASN513
I	ARG386

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ASP427
M	ASP427
M	ASP429
M	ASP490
A	ASP429
A	ASP490
E	ASP427
E	ASP429
E	ASP490
I	ASP427
I	ASP429
I	ASP490

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
A	ASP490

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
E	ASP490

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
I	ASP490

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
M	ASP490

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