1XNN

CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN T877A MUTANT COMPLEX WITH (3A-ALPHA-,4-ALPHA 7-ALPHA-,7A-ALPHA-)-3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE.

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HYQ A 101

Chain	Residue
A	HOH17
A	ARG752
A	PHE764
A	LEU873
A	ALA877
A	MET895
A	LEU704
A	ASN705
A	LEU707
A	GLY708
A	GLN711
A	MET742
A	MET745
A	MET749

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:11320241, ECO:0007744|PDB:1I37

Chain	Residue	Details
A	ASN705
A	ARG752
A	ALA877

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Interaction with coactivator LXXL and FXXFY motifs => ECO:0000250|UniProtKB:P10275

Chain	Residue	Details
A	LYS720

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Interaction with coactivator FXXLF and FXXFY motifs => ECO:0000250|UniProtKB:P10275

Chain	Residue	Details
A	GLU897

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by CSK => ECO:0000250|UniProtKB:P10275

Chain	Residue	Details
A	TYR915

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10275

Chain	Residue	Details
A	LYS845
A	LYS847

---