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Structure of human Dcps

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
A	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
A	0000340	molecular_function	RNA 7-methylguanosine cap binding
A	0000932	cellular_component	P-body
A	0004532	molecular_function	RNA exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0110156	biological_process	mRNA methylguanosine-cap decapping
A	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
B	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
B	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
B	0000340	molecular_function	RNA 7-methylguanosine cap binding
B	0000932	cellular_component	P-body
B	0004532	molecular_function	RNA exonuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
B	0045292	biological_process	mRNA cis splicing, via spliceosome
B	0110156	biological_process	mRNA methylguanosine-cap decapping
B	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 601

Chain	Residue
A	HIS268
A	SER272
A	HIS277
A	HIS279
A	HOH651

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 602

Chain	Residue
B	ARG294
B	HOH637
B	HOH777
B	HIS268
B	SER272
B	HIS277
B	HIS279

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Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. RvylhYlPsYyHLHVHFTA

Chain	Residue	Details
B	ARG264-ALA282

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
B	HIS277
A	HIS277

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:15068804, ECO:0000269|PubMed:15769464

Chain	Residue	Details
B	TRP175
B	GLU185
B	ASP205
B	LYS207
A	TRP175
A	GLU185
A	ASP205
A	LYS207

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
B	HIS268
A	HIS268

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	ALA2
A	ALA2

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER24
A	SER24

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9DAR7

Chain	Residue	Details
B	SER101
A	SER101

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS138
B	LYS142
A	LYS138
A	LYS142

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