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Structure of human Dcps

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
A	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
A	0000340	molecular_function	RNA 7-methylguanosine cap binding
A	0000932	cellular_component	P-body
A	0004532	molecular_function	RNA exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0110156	biological_process	mRNA methylguanosine-cap decapping
A	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
B	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
B	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
B	0000340	molecular_function	RNA 7-methylguanosine cap binding
B	0000932	cellular_component	P-body
B	0004532	molecular_function	RNA exonuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0045292	biological_process	mRNA cis splicing, via spliceosome
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0110156	biological_process	mRNA methylguanosine-cap decapping
B	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 601

Chain	Residue
A	HIS268
A	SER272
A	HIS277
A	HIS279
A	HOH651

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 602

Chain	Residue
B	ARG294
B	HOH637
B	HOH777
B	HIS268
B	SER272
B	HIS277
B	HIS279

---

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. RvylhYlPsYyHLHVHFTA

Chain	Residue	Details
B	ARG264-ALA282

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Motif: {"description":"nuclear export sequence (NES)"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"Histidine triad motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15068804","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15769464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DAR7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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