1XKY

Crystal Structure of Dihydrodipicolinate Synthase DapA-2 (BA3935) from Bacillus Anthracis at 1.94A Resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009085	biological_process	L-lysine biosynthetic process
A	0009089	biological_process	L-lysine biosynthetic process via diaminopimelate
A	0016829	molecular_function	lyase activity
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0044281	biological_process	small molecule metabolic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0009085	biological_process	L-lysine biosynthetic process
B	0009089	biological_process	L-lysine biosynthetic process via diaminopimelate
B	0016829	molecular_function	lyase activity
B	0019877	biological_process	diaminopimelate biosynthetic process
B	0044281	biological_process	small molecule metabolic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009085	biological_process	L-lysine biosynthetic process
C	0009089	biological_process	L-lysine biosynthetic process via diaminopimelate
C	0016829	molecular_function	lyase activity
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0044281	biological_process	small molecule metabolic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009085	biological_process	L-lysine biosynthetic process
D	0009089	biological_process	L-lysine biosynthetic process via diaminopimelate
D	0016829	molecular_function	lyase activity
D	0019877	biological_process	diaminopimelate biosynthetic process
D	0044281	biological_process	small molecule metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 1801

Chain	Residue
C	SER154
C	ILE156
C	GLU157
C	ILE159
C	HOH1971
C	HOH2132

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 1802

Chain	Residue
B	PHE183
B	HOH1888
B	HOH1910
B	ILE176
B	THR179
B	ALA180

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 1803

Chain	Residue
B	SER154
B	ILE156
B	GLU157
B	ILE159
B	HOH1942
B	HOH1946

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D 1804

Chain	Residue
D	ILE176
D	THR179
D	ALA180
D	PHE183
D	HOH1911
D	HOH1965

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 1805

Chain	Residue
C	ILE176
C	THR179
C	ALA180
C	PHE183
C	HOH1916
C	HOH1940

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1806

Chain	Residue
A	ILE176
A	THR179
A	ALA180
A	PHE183
A	HOH1896
A	HOH1956

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1807

Chain	Residue
A	SER154
A	ILE156
A	GLU157
A	ILE159
A	HOH1911
A	HOH1917

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D 1808

Chain	Residue
D	SER154
D	ILE156
D	GLU157
D	ILE159
D	HOH1967
D	HOH2111

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B 1809

Chain	Residue
B	ILE176
B	GLU177
B	THR179
B	HOH1888

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 1810

Chain	Residue
C	ILE176
C	GLU177
C	THR179
C	HOH1940

---

Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. AIVvgGTTGESptltseE

Chain	Residue	Details
A	ALA40-GLU57

---

site_id	PS00666
Number of Residues	31
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YNVPgrSivqIsvdtvvrlseien.IvAIKDA

Chain	Residue	Details
A	TYR135-ALA165

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1dhp

Chain	Residue	Details
A	TYR135
A	ARG140
A	LYS163

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1dhp

Chain	Residue	Details
B	TYR135
B	ARG140
B	LYS163

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1dhp

Chain	Residue	Details
C	TYR135
C	ARG140
C	LYS163

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1dhp

Chain	Residue	Details
D	TYR135
D	ARG140
D	LYS163

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1dhp

Chain	Residue	Details
A	THR47
A	THR46
A	LYS163

---

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1dhp

Chain	Residue	Details
B	THR47
B	THR46
B	LYS163

---

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1dhp

Chain	Residue	Details
C	THR47
C	THR46
C	LYS163

---

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1dhp

Chain	Residue	Details
D	THR47
D	THR46
D	LYS163

---