1XFV

Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005576	cellular_component	extracellular region
A	0008237	molecular_function	metallopeptidase activity
A	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0005576	cellular_component	extracellular region
B	0008237	molecular_function	metallopeptidase activity
B	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0005576	cellular_component	extracellular region
C	0008237	molecular_function	metallopeptidase activity
C	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0005576	cellular_component	extracellular region
D	0008237	molecular_function	metallopeptidase activity
D	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
D	0046872	molecular_function	metal ion binding
E	0003824	molecular_function	catalytic activity
E	0005576	cellular_component	extracellular region
E	0008237	molecular_function	metallopeptidase activity
E	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
E	0046872	molecular_function	metal ion binding
F	0003824	molecular_function	catalytic activity
F	0005576	cellular_component	extracellular region
F	0008237	molecular_function	metallopeptidase activity
F	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
F	0046872	molecular_function	metal ion binding
O	0000086	biological_process	G2/M transition of mitotic cell cycle
O	0000922	cellular_component	spindle pole
O	0002027	biological_process	regulation of heart rate
O	0005509	molecular_function	calcium ion binding
O	0005513	biological_process	detection of calcium ion
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005813	cellular_component	centrosome
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005876	cellular_component	spindle microtubule
O	0005886	cellular_component	plasma membrane
O	0007186	biological_process	G protein-coupled receptor signaling pathway
O	0008076	cellular_component	voltage-gated potassium channel complex
O	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
O	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
O	0010856	molecular_function	adenylate cyclase activator activity
O	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
O	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
O	0016020	cellular_component	membrane
O	0016240	biological_process	autophagosome membrane docking
O	0019855	molecular_function	calcium channel inhibitor activity
O	0019901	molecular_function	protein kinase binding
O	0021762	biological_process	substantia nigra development
O	0030017	cellular_component	sarcomere
O	0031432	molecular_function	titin binding
O	0031514	cellular_component	motile cilium
O	0031954	biological_process	positive regulation of protein autophosphorylation
O	0031982	cellular_component	vesicle
O	0032465	biological_process	regulation of cytokinesis
O	0032516	biological_process	obsolete positive regulation of phosphoprotein phosphatase activity
O	0032991	cellular_component	protein-containing complex
O	0034704	cellular_component	calcium channel complex
O	0035307	biological_process	obsolete positive regulation of protein dephosphorylation
O	0035458	biological_process	cellular response to interferon-beta
O	0043209	cellular_component	myelin sheath
O	0043539	molecular_function	protein serine/threonine kinase activator activity
O	0044305	cellular_component	calyx of Held
O	0044325	molecular_function	transmembrane transporter binding
O	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
O	0046872	molecular_function	metal ion binding
O	0048306	molecular_function	calcium-dependent protein binding
O	0050848	biological_process	regulation of calcium-mediated signaling
O	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
O	0051592	biological_process	response to calcium ion
O	0055117	biological_process	regulation of cardiac muscle contraction
O	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
O	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
O	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
O	0071346	biological_process	cellular response to type II interferon
O	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
O	0072542	molecular_function	protein phosphatase activator activity
O	0097225	cellular_component	sperm midpiece
O	0098901	biological_process	regulation of cardiac muscle cell action potential
O	0099523	cellular_component	presynaptic cytosol
O	0140056	biological_process	organelle localization by membrane tethering
O	0140238	biological_process	presynaptic endocytosis
O	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
O	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
O	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
O	1902494	cellular_component	catalytic complex
O	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
O	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
P	0000086	biological_process	G2/M transition of mitotic cell cycle
P	0000922	cellular_component	spindle pole
P	0002027	biological_process	regulation of heart rate
P	0005509	molecular_function	calcium ion binding
P	0005513	biological_process	detection of calcium ion
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005813	cellular_component	centrosome
P	0005819	cellular_component	spindle
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005876	cellular_component	spindle microtubule
P	0005886	cellular_component	plasma membrane
P	0007186	biological_process	G protein-coupled receptor signaling pathway
P	0008076	cellular_component	voltage-gated potassium channel complex
P	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
P	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
P	0010856	molecular_function	adenylate cyclase activator activity
P	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
P	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
P	0016020	cellular_component	membrane
P	0016240	biological_process	autophagosome membrane docking
P	0019855	molecular_function	calcium channel inhibitor activity
P	0019901	molecular_function	protein kinase binding
P	0021762	biological_process	substantia nigra development
P	0030017	cellular_component	sarcomere
P	0031432	molecular_function	titin binding
P	0031514	cellular_component	motile cilium
P	0031954	biological_process	positive regulation of protein autophosphorylation
P	0031982	cellular_component	vesicle
P	0032465	biological_process	regulation of cytokinesis
P	0032516	biological_process	obsolete positive regulation of phosphoprotein phosphatase activity
P	0032991	cellular_component	protein-containing complex
P	0034704	cellular_component	calcium channel complex
P	0035307	biological_process	obsolete positive regulation of protein dephosphorylation
P	0035458	biological_process	cellular response to interferon-beta
P	0043209	cellular_component	myelin sheath
P	0043539	molecular_function	protein serine/threonine kinase activator activity
P	0044305	cellular_component	calyx of Held
P	0044325	molecular_function	transmembrane transporter binding
P	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
P	0046872	molecular_function	metal ion binding
P	0048306	molecular_function	calcium-dependent protein binding
P	0050848	biological_process	regulation of calcium-mediated signaling
P	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
P	0051592	biological_process	response to calcium ion
P	0055117	biological_process	regulation of cardiac muscle contraction
P	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
P	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
P	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
P	0071346	biological_process	cellular response to type II interferon
P	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
P	0072542	molecular_function	protein phosphatase activator activity
P	0097225	cellular_component	sperm midpiece
P	0098901	biological_process	regulation of cardiac muscle cell action potential
P	0099523	cellular_component	presynaptic cytosol
P	0140056	biological_process	organelle localization by membrane tethering
P	0140238	biological_process	presynaptic endocytosis
P	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
P	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
P	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
P	1902494	cellular_component	catalytic complex
P	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
P	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
Q	0000086	biological_process	G2/M transition of mitotic cell cycle
Q	0000922	cellular_component	spindle pole
Q	0002027	biological_process	regulation of heart rate
Q	0005509	molecular_function	calcium ion binding
Q	0005513	biological_process	detection of calcium ion
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005819	cellular_component	spindle
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0005876	cellular_component	spindle microtubule
Q	0005886	cellular_component	plasma membrane
Q	0007186	biological_process	G protein-coupled receptor signaling pathway
Q	0008076	cellular_component	voltage-gated potassium channel complex
Q	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
Q	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
Q	0010856	molecular_function	adenylate cyclase activator activity
Q	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Q	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Q	0016020	cellular_component	membrane
Q	0016240	biological_process	autophagosome membrane docking
Q	0019855	molecular_function	calcium channel inhibitor activity
Q	0019901	molecular_function	protein kinase binding
Q	0021762	biological_process	substantia nigra development
Q	0030017	cellular_component	sarcomere
Q	0031432	molecular_function	titin binding
Q	0031514	cellular_component	motile cilium
Q	0031954	biological_process	positive regulation of protein autophosphorylation
Q	0031982	cellular_component	vesicle
Q	0032465	biological_process	regulation of cytokinesis
Q	0032516	biological_process	obsolete positive regulation of phosphoprotein phosphatase activity
Q	0032991	cellular_component	protein-containing complex
Q	0034704	cellular_component	calcium channel complex
Q	0035307	biological_process	obsolete positive regulation of protein dephosphorylation
Q	0035458	biological_process	cellular response to interferon-beta
Q	0043209	cellular_component	myelin sheath
Q	0043539	molecular_function	protein serine/threonine kinase activator activity
Q	0044305	cellular_component	calyx of Held
Q	0044325	molecular_function	transmembrane transporter binding
Q	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
Q	0046872	molecular_function	metal ion binding
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0050848	biological_process	regulation of calcium-mediated signaling
Q	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
Q	0051592	biological_process	response to calcium ion
Q	0055117	biological_process	regulation of cardiac muscle contraction
Q	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
Q	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
Q	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
Q	0071346	biological_process	cellular response to type II interferon
Q	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
Q	0072542	molecular_function	protein phosphatase activator activity
Q	0097225	cellular_component	sperm midpiece
Q	0098901	biological_process	regulation of cardiac muscle cell action potential
Q	0099523	cellular_component	presynaptic cytosol
Q	0140056	biological_process	organelle localization by membrane tethering
Q	0140238	biological_process	presynaptic endocytosis
Q	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
Q	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
Q	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
Q	1902494	cellular_component	catalytic complex
Q	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
Q	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
R	0000086	biological_process	G2/M transition of mitotic cell cycle
R	0000922	cellular_component	spindle pole
R	0002027	biological_process	regulation of heart rate
R	0005509	molecular_function	calcium ion binding
R	0005513	biological_process	detection of calcium ion
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005819	cellular_component	spindle
R	0005829	cellular_component	cytosol
R	0005856	cellular_component	cytoskeleton
R	0005876	cellular_component	spindle microtubule
R	0005886	cellular_component	plasma membrane
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0008076	cellular_component	voltage-gated potassium channel complex
R	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
R	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
R	0010856	molecular_function	adenylate cyclase activator activity
R	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
R	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
R	0016020	cellular_component	membrane
R	0016240	biological_process	autophagosome membrane docking
R	0019855	molecular_function	calcium channel inhibitor activity
R	0019901	molecular_function	protein kinase binding
R	0021762	biological_process	substantia nigra development
R	0030017	cellular_component	sarcomere
R	0031432	molecular_function	titin binding
R	0031514	cellular_component	motile cilium
R	0031954	biological_process	positive regulation of protein autophosphorylation
R	0031982	cellular_component	vesicle
R	0032465	biological_process	regulation of cytokinesis
R	0032516	biological_process	obsolete positive regulation of phosphoprotein phosphatase activity
R	0032991	cellular_component	protein-containing complex
R	0034704	cellular_component	calcium channel complex
R	0035307	biological_process	obsolete positive regulation of protein dephosphorylation
R	0035458	biological_process	cellular response to interferon-beta
R	0043209	cellular_component	myelin sheath
R	0043539	molecular_function	protein serine/threonine kinase activator activity
R	0044305	cellular_component	calyx of Held
R	0044325	molecular_function	transmembrane transporter binding
R	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
R	0046872	molecular_function	metal ion binding
R	0048306	molecular_function	calcium-dependent protein binding
R	0050848	biological_process	regulation of calcium-mediated signaling
R	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
R	0051592	biological_process	response to calcium ion
R	0055117	biological_process	regulation of cardiac muscle contraction
R	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
R	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
R	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
R	0071346	biological_process	cellular response to type II interferon
R	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
R	0072542	molecular_function	protein phosphatase activator activity
R	0097225	cellular_component	sperm midpiece
R	0098901	biological_process	regulation of cardiac muscle cell action potential
R	0099523	cellular_component	presynaptic cytosol
R	0140056	biological_process	organelle localization by membrane tethering
R	0140238	biological_process	presynaptic endocytosis
R	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
R	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
R	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
R	1902494	cellular_component	catalytic complex
R	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
R	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
S	0000086	biological_process	G2/M transition of mitotic cell cycle
S	0000922	cellular_component	spindle pole
S	0002027	biological_process	regulation of heart rate
S	0005509	molecular_function	calcium ion binding
S	0005513	biological_process	detection of calcium ion
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005819	cellular_component	spindle
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005876	cellular_component	spindle microtubule
S	0005886	cellular_component	plasma membrane
S	0007186	biological_process	G protein-coupled receptor signaling pathway
S	0008076	cellular_component	voltage-gated potassium channel complex
S	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
S	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
S	0010856	molecular_function	adenylate cyclase activator activity
S	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
S	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
S	0016020	cellular_component	membrane
S	0016240	biological_process	autophagosome membrane docking
S	0019855	molecular_function	calcium channel inhibitor activity
S	0019901	molecular_function	protein kinase binding
S	0021762	biological_process	substantia nigra development
S	0030017	cellular_component	sarcomere
S	0031432	molecular_function	titin binding
S	0031514	cellular_component	motile cilium
S	0031954	biological_process	positive regulation of protein autophosphorylation
S	0031982	cellular_component	vesicle
S	0032465	biological_process	regulation of cytokinesis
S	0032516	biological_process	obsolete positive regulation of phosphoprotein phosphatase activity
S	0032991	cellular_component	protein-containing complex
S	0034704	cellular_component	calcium channel complex
S	0035307	biological_process	obsolete positive regulation of protein dephosphorylation
S	0035458	biological_process	cellular response to interferon-beta
S	0043209	cellular_component	myelin sheath
S	0043539	molecular_function	protein serine/threonine kinase activator activity
S	0044305	cellular_component	calyx of Held
S	0044325	molecular_function	transmembrane transporter binding
S	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
S	0046872	molecular_function	metal ion binding
S	0048306	molecular_function	calcium-dependent protein binding
S	0050848	biological_process	regulation of calcium-mediated signaling
S	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
S	0051592	biological_process	response to calcium ion
S	0055117	biological_process	regulation of cardiac muscle contraction
S	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
S	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
S	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
S	0071346	biological_process	cellular response to type II interferon
S	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
S	0072542	molecular_function	protein phosphatase activator activity
S	0097225	cellular_component	sperm midpiece
S	0098901	biological_process	regulation of cardiac muscle cell action potential
S	0099523	cellular_component	presynaptic cytosol
S	0140056	biological_process	organelle localization by membrane tethering
S	0140238	biological_process	presynaptic endocytosis
S	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
S	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
S	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
S	1902494	cellular_component	catalytic complex
S	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
S	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
T	0000086	biological_process	G2/M transition of mitotic cell cycle
T	0000922	cellular_component	spindle pole
T	0002027	biological_process	regulation of heart rate
T	0005509	molecular_function	calcium ion binding
T	0005513	biological_process	detection of calcium ion
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005813	cellular_component	centrosome
T	0005819	cellular_component	spindle
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005876	cellular_component	spindle microtubule
T	0005886	cellular_component	plasma membrane
T	0007186	biological_process	G protein-coupled receptor signaling pathway
T	0008076	cellular_component	voltage-gated potassium channel complex
T	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
T	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
T	0010856	molecular_function	adenylate cyclase activator activity
T	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
T	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
T	0016020	cellular_component	membrane
T	0016240	biological_process	autophagosome membrane docking
T	0019855	molecular_function	calcium channel inhibitor activity
T	0019901	molecular_function	protein kinase binding
T	0021762	biological_process	substantia nigra development
T	0030017	cellular_component	sarcomere
T	0031432	molecular_function	titin binding
T	0031514	cellular_component	motile cilium
T	0031954	biological_process	positive regulation of protein autophosphorylation
T	0031982	cellular_component	vesicle
T	0032465	biological_process	regulation of cytokinesis
T	0032516	biological_process	obsolete positive regulation of phosphoprotein phosphatase activity
T	0032991	cellular_component	protein-containing complex
T	0034704	cellular_component	calcium channel complex
T	0035307	biological_process	obsolete positive regulation of protein dephosphorylation
T	0035458	biological_process	cellular response to interferon-beta
T	0043209	cellular_component	myelin sheath
T	0043539	molecular_function	protein serine/threonine kinase activator activity
T	0044305	cellular_component	calyx of Held
T	0044325	molecular_function	transmembrane transporter binding
T	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
T	0046872	molecular_function	metal ion binding
T	0048306	molecular_function	calcium-dependent protein binding
T	0050848	biological_process	regulation of calcium-mediated signaling
T	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
T	0051592	biological_process	response to calcium ion
T	0055117	biological_process	regulation of cardiac muscle contraction
T	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
T	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
T	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
T	0071346	biological_process	cellular response to type II interferon
T	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
T	0072542	molecular_function	protein phosphatase activator activity
T	0097225	cellular_component	sperm midpiece
T	0098901	biological_process	regulation of cardiac muscle cell action potential
T	0099523	cellular_component	presynaptic cytosol
T	0140056	biological_process	organelle localization by membrane tethering
T	0140238	biological_process	presynaptic endocytosis
T	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
T	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
T	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
T	1902494	cellular_component	catalytic complex
T	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
T	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA O 701

Chain	Residue
O	ASP20
O	ASP22
O	ASP24
O	THR26

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA P 703

Chain	Residue
P	ASP20
P	ASP22
P	ASP24
P	THR26

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA Q 705

Chain	Residue
Q	ASP22
Q	ASP24
Q	THR26
Q	ASP20

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA R 707

Chain	Residue
R	ASP20
R	ASP22
R	ASP24
R	THR26

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA S 709

Chain	Residue
S	ASP20
S	ASP22
S	ASP24
S	THR26

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA T 711

Chain	Residue
T	ASP20
T	ASP22
T	ASP24
T	THR26

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA O 801

Chain	Residue
O	ASP129
O	ASP131
O	ASP133
O	GLN135
O	GLU140

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA O 802

Chain	Residue
O	ASP93
O	ASP95
O	ASN97
O	TYR99
O	GLU104

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA P 803

Chain	Residue
P	ASP129
P	ASP131
P	ASP133
P	GLN135
P	GLU140

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA P 804

Chain	Residue
P	ASP93
P	ASP95
P	ASN97
P	TYR99
P	GLU104

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA Q 805

Chain	Residue
Q	ASP129
Q	ASP131
Q	ASP133
Q	GLN135
Q	GLU140

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA Q 806

Chain	Residue
Q	ASP93
Q	ASP95
Q	ASN97
Q	TYR99
Q	GLU104

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA R 807

Chain	Residue
R	ASP129
R	ASP131
R	ASP133
R	GLN135
R	GLU140

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA R 808

Chain	Residue
R	ASP93
R	ASP95
R	ASN97
R	TYR99
R	GLU104

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA S 809

Chain	Residue
S	ASP129
S	ASP131
S	ASP133
S	GLN135
S	GLU140

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA S 810

Chain	Residue
S	ASP93
S	ASP95
S	ASN97
S	TYR99
S	GLU104

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA T 811

Chain	Residue
T	ASP129
T	ASP131
T	ASP133
T	GLN135
T	GLU140

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA T 812

Chain	Residue
T	ASP93
T	ASP95
T	ASN97
T	TYR99
T	GLU104

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 901

Chain	Residue
A	ASP491
A	ASP493
A	HIS577

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 902

Chain	Residue
B	ASP491
B	ASP493
B	HIS577

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 903

Chain	Residue
C	ASP491
C	ASP493
C	HIS577

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 904

Chain	Residue
D	ASP491
D	ASP493
D	HIS577

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 905

Chain	Residue
E	ASP491
E	ASP493
E	HIS577

---

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG F 906

Chain	Residue
F	ASP491
F	ASP493
F	HIS577

---

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 902

Chain	Residue
A	LYS346
A	3AT903

---

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 903

Chain	Residue
B	LYS346
B	3AT904

---

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG C 904

Chain	Residue
C	3AT905

---

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 905

Chain	Residue
D	3AT906

---

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 906

Chain	Residue
E	LYS346
E	3AT907

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG F 907

Chain	Residue
F	LYS346
F	3AT908

---

site_id	DC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3AT A 903

Chain	Residue
A	HOH1
A	ARG329
A	LYS346
A	LEU348
A	LYS353
A	LYS372
A	ASP493
A	GLY547
A	THR548
A	GLY578
A	GLU588
A	MG902

---

site_id	DC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3AT B 904

Chain	Residue
B	HOH2
B	ARG329
B	LYS346
B	LEU348
B	LYS353
B	LYS372
B	ASP493
B	GLY547
B	THR548
B	GLY578
B	GLU588
B	MG903

---

site_id	DC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3AT C 905

Chain	Residue
C	HOH3
C	ARG329
C	LYS346
C	LEU348
C	LYS353
C	LYS372
C	ASP493
C	GLY547
C	THR548
C	GLY578
C	GLU588
C	MG904

---

site_id	DC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3AT D 906

Chain	Residue
D	HOH4
D	ARG329
D	LYS346
D	LEU348
D	LYS353
D	LYS372
D	ASP493
D	GLY547
D	THR548
D	GLY578
D	GLU588
D	MG905

---

site_id	DC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3AT E 907

Chain	Residue
E	HOH5
E	ARG329
E	LYS346
E	LEU348
E	LYS353
E	LYS372
E	ASP493
E	GLY547
E	THR548
E	GLY578
E	GLU588
E	MG906

---

site_id	DC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3AT F 908

Chain	Residue
F	HOH6
F	ARG329
F	LYS346
F	LEU348
F	LYS353
F	LYS372
F	ASP493
F	GLY547
F	THR548
F	GLY578
F	GLU588
F	MG907

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
O	ASP20-LEU32
O	ASP56-PHE68
O	ASP93-LEU105
O	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03

Chain	Residue	Details
O	ASP20
O	GLU67
P	ASP20
P	ASP22
P	ASP24
P	THR26
P	GLU31
P	ASP56
P	ASP58
P	ASN60
P	THR62
O	ASP22
P	GLU67
Q	ASP20
Q	ASP22
Q	ASP24
Q	THR26
Q	GLU31
Q	ASP56
Q	ASP58
Q	ASN60
Q	THR62
O	ASP24
Q	GLU67
R	ASP20
R	ASP22
R	ASP24
R	THR26
R	GLU31
R	ASP56
R	ASP58
R	ASN60
R	THR62
O	THR26
R	GLU67
S	ASP20
S	ASP22
S	ASP24
S	THR26
S	GLU31
S	ASP56
S	ASP58
S	ASN60
S	THR62
O	GLU31
S	GLU67
T	ASP20
T	ASP22
T	ASP24
T	THR26
T	GLU31
T	ASP56
T	ASP58
T	ASN60
T	THR62
O	ASP56
T	GLU67
O	ASP58
O	ASN60
O	THR62

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0000269|PubMed:29724949, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03, ECO:0007744|PDB:6CNN, ECO:0007744|PDB:6CNO

Chain	Residue	Details
O	ASP93
P	GLU104
Q	ASP93
Q	ASP95
Q	ASN97
Q	TYR99
Q	GLU104
R	ASP93
R	ASP95
R	ASN97
R	TYR99
O	ASP95
R	GLU104
S	ASP93
S	ASP95
S	ASN97
S	TYR99
S	GLU104
T	ASP93
T	ASP95
T	ASN97
T	TYR99
O	ASN97
T	GLU104
O	TYR99
O	GLU104
P	ASP93
P	ASP95
P	ASN97
P	TYR99

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03

Chain	Residue	Details
O	ASP129
P	GLU140
Q	ASP129
Q	ASP131
Q	ASP133
Q	GLN135
Q	GLU140
R	ASP129
R	ASP131
R	ASP133
R	GLN135
O	ASP131
R	GLU140
S	ASP129
S	ASP131
S	ASP133
S	GLN135
S	GLU140
T	ASP129
T	ASP131
T	ASP133
T	GLN135
O	ASP133
T	GLU140
O	GLN135
O	GLU140
P	ASP129
P	ASP131
P	ASP133
P	GLN135

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
O	ALA1
P	ALA1
Q	ALA1
R	ALA1
S	ALA1
T	ALA1

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
O	LYS21
P	LYS21
Q	LYS21
R	LYS21
S	LYS21
T	LYS21

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
O	THR44
P	THR44
Q	THR44
R	THR44
S	THR44
T	THR44

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
O	SER81
P	SER81
Q	SER81
R	SER81
S	SER81
T	SER81

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
O	LYS94
P	LYS94
Q	LYS94
R	LYS94
S	LYS94
T	LYS94

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
O	TYR99
P	TYR99
Q	TYR99
R	TYR99
S	TYR99
T	TYR99

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
O	SER101
P	SER101
Q	SER101
R	SER101
S	SER101
T	SER101

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
O	THR110
P	THR110
Q	THR110
R	THR110
S	THR110
T	THR110

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
O	LYS115
P	LYS115
Q	LYS115
R	LYS115
S	LYS115
T	LYS115

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
O	TYR138
P	TYR138
Q	TYR138
R	TYR138
S	TYR138
T	TYR138

---

site_id	SWS_FT_FI14
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
O	LYS21
T	LYS21
P	LYS21
Q	LYS21
R	LYS21
S	LYS21

---