1XCJ
Guanidinoacetate methyltransferase containing S-adenosylhomocysteine and guanidinoacetate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006601 | biological_process | creatine biosynthetic process |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0009887 | biological_process | animal organ morphogenesis |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019702 | molecular_function | protein arginine N5-methyltransferase activity |
| A | 0030731 | molecular_function | guanidinoacetate N-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0040014 | biological_process | regulation of multicellular organism growth |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046498 | biological_process | S-adenosylhomocysteine metabolic process |
| A | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| A | 1990402 | biological_process | embryonic liver development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE SAH A 236 |
| Chain | Residue |
| A | TRP19 |
| A | ILE72 |
| A | ALA73 |
| A | GLU89 |
| A | CYS90 |
| A | ASN91 |
| A | VAL94 |
| A | GLY114 |
| A | LEU115 |
| A | TRP116 |
| A | GLU117 |
| A | VAL40 |
| A | ASP134 |
| A | THR135 |
| A | TYR136 |
| A | LEU138 |
| A | HOH1002 |
| A | MET41 |
| A | MET49 |
| A | GLY67 |
| A | PHE68 |
| A | GLY69 |
| A | MET70 |
| A | ALA71 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NMG A 237 |
| Chain | Residue |
| A | VAL40 |
| A | MET41 |
| A | GLU45 |
| A | ASP134 |
| A | THR135 |
| A | CYS168 |
| A | ASN169 |
| A | LEU170 |
| A | THR171 |
| A | HOH1009 |
| A | HOH1052 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG20 | |
| A | HIS50 | |
| A | GLY69 | |
| A | GLU117 | |
| A | THR135 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00892, ECO:0000269|PubMed:15533043, ECO:0007744|PDB:1XCJ |
| Chain | Residue | Details |
| A | GLU42 | |
| A | THR46 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15533043, ECO:0007744|PDB:1XCJ |
| Chain | Residue | Details |
| A | THR171 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:Q14353 |
| Chain | Residue | Details |
| A | SER2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | PRO7 |
