1XCB

X-ray Structure of a Rex-Family Repressor/NADH Complex from Thermus Aquaticus

Replaces:  1R72

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0051775	biological_process	response to redox state
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0051775	biological_process	response to redox state
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005737	cellular_component	cytoplasm
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0051775	biological_process	response to redox state
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005737	cellular_component	cytoplasm
D	0006351	biological_process	DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0051775	biological_process	response to redox state
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005737	cellular_component	cytoplasm
E	0006351	biological_process	DNA-templated transcription
E	0006355	biological_process	regulation of DNA-templated transcription
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0051775	biological_process	response to redox state
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005737	cellular_component	cytoplasm
F	0006351	biological_process	DNA-templated transcription
F	0006355	biological_process	regulation of DNA-templated transcription
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0051775	biological_process	response to redox state
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005737	cellular_component	cytoplasm
G	0006351	biological_process	DNA-templated transcription
G	0006355	biological_process	regulation of DNA-templated transcription
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0051775	biological_process	response to redox state

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 212

Chain	Residue
B	GLY139
G	GLY139

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA D 212

Chain	Residue
D	GLY139
E	GLY139

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA D 213

Chain	Residue
D	VAL187
D	ASP188

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD A 213

Chain	Residue
A	GLY89
A	ARG90
A	LEU91
A	ASP112
A	VAL113
A	ASP114
A	LYS117
A	THR147
A	VAL148
A	PRO149
A	ALA152
A	ALA156
A	PHE171
A	ALA172
A	PRO173
A	VAL187
A	PHE189
B	HIS27
B	ALA94
B	TYR98
A	VAL86
A	GLY87
A	MSE88

---

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAD B 213

Chain	Residue
A	ALA94
A	TYR98
A	PHE189
B	VAL86
B	GLY87
B	MSE88
B	GLY89
B	ARG90
B	LEU91
B	ASP112
B	VAL113
B	LYS117
B	THR147
B	VAL148
B	PRO149
B	ARG150
B	ALA152
B	PHE171
B	PRO173
B	VAL187
B	PHE189

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAD C 213

Chain	Residue
C	GLY87
C	MSE88
C	GLY89
C	ARG90
C	LEU91
C	ASP112
C	VAL113
C	ASP114
C	LYS117
C	THR147
C	VAL148
C	PRO149
C	ARG150
C	PHE171
C	ALA172
C	PRO173
C	VAL187
C	PHE189
D	ALA94
D	TYR98

---

site_id	AC7
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD D 214

Chain	Residue
C	ALA94
C	TYR98
C	PHE189
D	VAL86
D	GLY87
D	MSE88
D	GLY89
D	ARG90
D	LEU91
D	ASP112
D	VAL113
D	ASP114
D	LYS117
D	VAL130
D	THR147
D	VAL148
D	PRO149
D	ARG150
D	PHE171
D	ALA172
D	PRO173
D	VAL187
D	ASP188
D	PHE189

---

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD E 212

Chain	Residue
E	ARG90
E	LEU91
E	ASP112
E	VAL113
E	ASP114
E	LYS117
E	THR147
E	VAL148
E	PRO149
E	ARG150
E	ALA152
E	PHE171
E	ALA172
E	PRO173
E	VAL187
E	PHE189
F	ALA94
F	TYR98
A	PHE43
A	ARG46
E	GLY87
E	MSE88
E	GLY89

---

site_id	AC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NAD F 212

Chain	Residue
E	ALA94
E	TYR98
F	VAL86
F	MSE88
F	GLY89
F	ARG90
F	LEU91
F	ASP112
F	VAL113
F	ASP114
F	LYS117
F	VAL130
F	THR147
F	VAL148
F	PRO149
F	ARG150
F	ALA152
F	PHE171
F	PRO173
F	VAL187
F	ASP188
F	PHE189

---

site_id	BC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NAD G 212

Chain	Residue
C	PHE43
C	ARG46
G	GLY87
G	MSE88
G	GLY89
G	ARG90
G	LEU91
G	ALA94
G	TYR98
G	ASP112
G	VAL113
G	ASP114
G	LYS117
G	VAL130
G	VAL148
G	PRO149
G	ALA152
G	PHE171
G	ALA172
G	PRO173
G	VAL187
G	PHE189

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	117
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_01131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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