Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1WYV

Crystal structure of glycine decarboxylase (P-protein) of the glycine cleavage system, in inhibitor-bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004375	molecular_function	glycine dehydrogenase (decarboxylating) activity
A	0006546	biological_process	glycine catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019464	biological_process	glycine decarboxylation via glycine cleavage system
B	0004375	molecular_function	glycine dehydrogenase (decarboxylating) activity
B	0005829	cellular_component	cytosol
B	0005960	cellular_component	glycine cleavage complex
B	0006546	biological_process	glycine catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016594	molecular_function	glycine binding
B	0019464	biological_process	glycine decarboxylation via glycine cleavage system
B	0030170	molecular_function	pyridoxal phosphate binding
C	0004375	molecular_function	glycine dehydrogenase (decarboxylating) activity
C	0006546	biological_process	glycine catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0019464	biological_process	glycine decarboxylation via glycine cleavage system
D	0004375	molecular_function	glycine dehydrogenase (decarboxylating) activity
D	0005829	cellular_component	cytosol
D	0005960	cellular_component	glycine cleavage complex
D	0006546	biological_process	glycine catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016594	molecular_function	glycine binding
D	0019464	biological_process	glycine decarboxylation via glycine cleavage system
D	0030170	molecular_function	pyridoxal phosphate binding
E	0004375	molecular_function	glycine dehydrogenase (decarboxylating) activity
E	0006546	biological_process	glycine catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0019464	biological_process	glycine decarboxylation via glycine cleavage system
F	0004375	molecular_function	glycine dehydrogenase (decarboxylating) activity
F	0005829	cellular_component	cytosol
F	0005960	cellular_component	glycine cleavage complex
F	0006546	biological_process	glycine catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016594	molecular_function	glycine binding
F	0019464	biological_process	glycine decarboxylation via glycine cleavage system
F	0030170	molecular_function	pyridoxal phosphate binding
G	0004375	molecular_function	glycine dehydrogenase (decarboxylating) activity
G	0006546	biological_process	glycine catabolic process
G	0009116	biological_process	nucleoside metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0019464	biological_process	glycine decarboxylation via glycine cleavage system
H	0004375	molecular_function	glycine dehydrogenase (decarboxylating) activity
H	0005829	cellular_component	cytosol
H	0005960	cellular_component	glycine cleavage complex
H	0006546	biological_process	glycine catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016594	molecular_function	glycine binding
H	0019464	biological_process	glycine decarboxylation via glycine cleavage system
H	0030170	molecular_function	pyridoxal phosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PLP B 1475

Chain	Residue
A	THR320
B	SER168
B	ASP239
B	ALA241
B	ASN263
B	HIS265
B	LYS266
B	AOA1476
B	HOH1516
A	THR321
A	HOH496
B	SER73
B	ALA131
B	GLY132
B	ALA133
B	GLU136
B	HIS166

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE AOA B 1476

Chain	Residue
A	TYR95
A	TYR98
A	GLN308
A	THR320
A	HOH521
B	HIS166
B	PLP1475
B	HOH1615

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP D 2475

Chain	Residue
C	THR320
C	THR321
C	HOH497
D	SER73
D	GLY132
D	ALA133
D	GLU136
D	HIS166
D	SER168
D	ASP239
D	ALA241
D	ASN263
D	HIS265
D	LYS266
D	AOA2476

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE AOA D 2476

Chain	Residue
C	TYR95
C	TYR98
C	GLN308
C	THR320
C	HOH583
D	HIS166
D	PLP2475
D	HOH2586

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PLP F 3475

Chain	Residue
E	THR320
E	THR321
E	HOH463
E	HOH573
F	SER73
F	ALA131
F	GLY132
F	ALA133
F	GLU136
F	HIS166
F	SER168
F	ASP239
F	ALA241
F	ASN263
F	HIS265
F	LYS266
F	AOA3476

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AOA F 3476

Chain	Residue
E	TYR95
E	TYR98
E	GLN308
E	THR320
F	HIS166
F	PLP3475

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP H 4475

Chain	Residue
G	THR320
G	THR321
H	SER73
H	GLY132
H	ALA133
H	GLU136
H	HIS166
H	SER168
H	ASP239
H	ALA241
H	ASN263
H	HIS265
H	LYS266
H	AOA4476
H	HOH4496

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE AOA H 4476

Chain	Residue
G	TYR95
G	TYR98
G	GLN308
G	THR320
G	HOH568
H	HIS166
H	PLP4475

Functional Information from PROSITE/UniProt

site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. LpLeGGrTPLPeVgE

Chain	Residue	Details
A	LEU181-GLU195

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255\|HAMAP-Rule:MF_00713

Chain	Residue	Details
B	LYS266
D	LYS266
F	LYS266
H	LYS266

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1cs1

Chain	Residue	Details
F	GLN103

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1cs1

Chain	Residue	Details
H	GLN103

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1cs1

Chain	Residue	Details
B	GLN103

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1cs1

Chain	Residue	Details
D	GLN103

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)