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1WY9

Crystal structure of microglia-specific protein, Iba1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0001774biological_processmicroglial cell activation
A0001891cellular_componentphagocytic cup
A0003779molecular_functionactin binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0006911biological_processphagocytosis, engulfment
A0006954biological_processinflammatory response
A0008284biological_processpositive regulation of cell population proliferation
A0016020cellular_componentmembrane
A0016601biological_processRac protein signal transduction
A0030027cellular_componentlamellipodium
A0030041biological_processactin filament polymerization
A0030046biological_processparallel actin filament bundle assembly
A0030335biological_processpositive regulation of cell migration
A0032587cellular_componentruffle membrane
A0032722biological_processpositive regulation of chemokine production
A0032755biological_processpositive regulation of interleukin-6 production
A0034599biological_processcellular response to oxidative stress
A0042102biological_processpositive regulation of T cell proliferation
A0042995cellular_componentcell projection
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050921biological_processpositive regulation of chemotaxis
A0051015molecular_functionactin filament binding
A0051017biological_processactin filament bundle assembly
A0051764biological_processactin crosslink formation
A0071346biological_processcellular response to type II interferon
A0071672biological_processnegative regulation of smooth muscle cell chemotaxis
A0071673biological_processpositive regulation of smooth muscle cell chemotaxis
A0071677biological_processpositive regulation of mononuclear cell migration
A0090026biological_processpositive regulation of monocyte chemotaxis
A0090271biological_processpositive regulation of fibroblast growth factor production
A0097178biological_processruffle assembly
A0097386cellular_componentglial cell projection
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A2000406biological_processpositive regulation of T cell migration
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 148
ChainResidue
ASER94
AGLY96
ASER97
ATHR100
AASP105
AHOH170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues35
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues34
DetailsDomain: {"description":"EF-hand 2; degenerate","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues7
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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