1WXE
E.coli NAD Synthetase, AMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003952 | molecular_function | NAD+ synthase (glutamine-hydrolyzing) activity |
| A | 0004359 | molecular_function | glutaminase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008795 | molecular_function | NAD+ synthase activity |
| A | 0009435 | biological_process | NAD biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0034355 | biological_process | NAD salvage |
| A | 0034628 | biological_process | 'de novo' NAD biosynthetic process from aspartate |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 300 |
| Chain | Residue |
| A | ASP52 |
| A | GLU165 |
| A | HOH569 |
| A | HOH581 |
| A | HOH637 |
| A | HOH640 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AMP A 400 |
| Chain | Residue |
| A | SER53 |
| A | VAL81 |
| A | LEU83 |
| A | ARG142 |
| A | THR160 |
| A | ASP176 |
| A | HOH591 |
| A | HOH637 |
| A | HOH638 |
| A | HOH640 |
| A | HOH696 |
| A | GLY46 |
| A | ILE47 |
| A | SER48 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AMP A 500 |
| Chain | Residue |
| A | TYR33 |
| A | ASN136 |
| A | ARG140 |
| A | TYR147 |
| A | GLY155 |
| A | VAL156 |
| A | PHE171 |
| A | THR172 |
| A | LYS173 |
| A | ASP180 |
| A | HIS260 |
| A | LYS261 |
| A | HOH614 |
| A | HOH673 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXG |
| Chain | Residue | Details |
| A | TYR33 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00193, ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXE, ECO:0007744|PDB:1WXI |
| Chain | Residue | Details |
| A | GLY46 | |
| A | THR160 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00193, ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXG, ECO:0007744|PDB:1WXH |
| Chain | Residue | Details |
| A | ASP52 | |
| A | GLU165 | |
| A | LYS173 | |
| A | HIS260 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXE, ECO:0007744|PDB:1WXI |
| Chain | Residue | Details |
| A | ARG82 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXI |
| Chain | Residue | Details |
| A | GLN88 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXH |
| Chain | Residue | Details |
| A | ASN136 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00193, ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXE, ECO:0007744|PDB:1WXG, ECO:0007744|PDB:1WXH, ECO:0007744|PDB:1WXI |
| Chain | Residue | Details |
| A | ARG140 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00193, ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXG |
| Chain | Residue | Details |
| A | ASP180 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00193, ECO:0000269|PubMed:15699042, ECO:0007744|PDB:1WXI |
| Chain | Residue | Details |
| A | LYS189 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00193 |
| Chain | Residue | Details |
| A | THR211 |
